Zobrazeno 1 - 10
of 235
pro vyhledávání: '"James M. Parry"'
PCR-Based Methodology for the Determination of the Photoprotection Afforded by Sunscreen Application
Autor:
Gareth J.S. Jenkins, James M. Parry
Publikováno v:
BioTechniques, Vol 29, Iss 6, Pp 1318-1326 (2000)
We have applied a PCR-based methodology to study the DNA damage induced by UV-A, UV-B and sunlight itself. Our results, employing a cell-free system, indicate that UV-B (310 nm) is approximately 30-fold more potent at inhibiting DNA synthesis than UV
Externí odkaz:
https://doaj.org/article/e43c3eed318249c7b9dcac83c12a3932
Publikováno v:
Mutagenesis. 25:531-538
The ability of the in vitro mammalian cell tests currently used to identify genotoxins has been shown to be limited by a high rate of false-positive results, triggering further unnecessary testing in vivo. During an European Centre for the Validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f593b87fadce06b96491db9b393309
https://doi.org/10.1093/mutage/geq046
https://doi.org/10.1093/mutage/geq046
Autor:
James M. Parry, Mahmood Akhtar Kayani
Publikováno v:
Toxicology in Vitro. 24:56-60
Ability of ethanol to produce chromosomal changes has been controversial in past many years; nevertheless many recent studies have shown that ethanol itself produces genotoxic effects like acetaldehyde. This study was carried out to evaluate the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd438b63f6151cf145e9e6387d06cc07
https://doi.org/10.1016/j.tiv.2009.09.003
https://doi.org/10.1016/j.tiv.2009.09.003
Publikováno v:
Environmental and Molecular Mutagenesis. 50:277-284
Xenobiotic diacylglycerols (DG) may induce pathological disorders by causing abnormal chromosomal segregation, which could be aneuploid. In this study, seven xenobiotic-diacylglycerols (four of drug origin and three of pesticide origin) were evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6780d15bf5647f058b4c6c2c1d98cd
https://doi.org/10.1002/em.20445
https://doi.org/10.1002/em.20445
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 651:46-55
The study was concerned with investigating the specific effects of non-DNA reactive oestrogens at low "biologically relevant" doses and the causative role they may play in breast cancer through inducing aneuploidy. A review of previous studies identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9d9406a0b226cc3eec53b2e38bd0f5
https://doi.org/10.1016/j.mrgentox.2007.10.021
https://doi.org/10.1016/j.mrgentox.2007.10.021
Autor:
James M. Parry, Timson C Appanna, Shareen H. Doak, Howard Kynaston, Spencer A. Jenkins, T.P. Stephenson
Publikováno v:
International Journal of Urology. 14:539-544
Objective: Tumors arising within augmentation cystoplasties are aggressive, have poor prognosis and the majority are not detected at follow-up cystoscopy. Genetic changes in tumors precede morphological abnormalities. Therefore, the aim of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14833a88f050557a9e4732e4d315a946
https://doi.org/10.1111/j.1442-2042.2006.01724.x
https://doi.org/10.1111/j.1442-2042.2006.01724.x
Autor:
Emma Quick, Shareen H. Doak, George E. Johnson, James M. Parry, Gareth J.S. Jenkins, Elizabeth M. Parry
Publikováno v:
Cancer Research. 67:3904-3911
A mechanistic understanding of carcinogenic genotoxicity is necessary to determine consequences of chemical exposure on human populations and improve health risk assessments. Currently, linear dose-responses are assumed for DNA reactive compounds, ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a202ae6020530f2764d385a92a974b29
https://doi.org/10.1158/0008-5472.can-06-4061
https://doi.org/10.1158/0008-5472.can-06-4061
Autor:
James M. Parry, Paul W. Hastwell, Jean-Roc Meunier, Véronique Thybaud, Daniel Marzin, Lutz Müller, Firouz Darroudi, Anthony M. Lynch, Marilyn J. Aardema, Paul D. White, David Tweats, Azeddine Elhajouji, Gerhard J. Nohynek, Ray Tice, Daniela Maurici, Peter Kasper, M. Hayashi, Stefan Pfuhler, Stephan Kirchner, Raffaella Corvi, Elizabeth M. Parry, Philippe Vanparys, David Kirkland, Jan van Benthem, Hansruedi Glatt
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 628:31-55
Workshop participants agreed that genotoxicity tests in mammalian cells in vitro produce a remarkably high and unacceptable occurrence of irrelevant positive results (e.g. when compared with rodent carcinogenicity). As reported in several recent revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9004d727d7e62fbdc76d98d8a339d5
https://doi.org/10.1016/j.mrgentox.2006.11.008
https://doi.org/10.1016/j.mrgentox.2006.11.008
Autor:
Spencer A. Jenkins, James M. Parry, K D Ivil, T.P. Stephenson, Howard Kynaston, Shareen H. Doak, Elizabeth M. Parry
Publikováno v:
British Journal of Cancer
The incidence of carcinoma following an enterocystoplasty increases with time and is a major concern after such procedures. The aim of this study was to investigate genetic instability (in the form of numerical chromosomal aberrations) at the enterov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99038a71552c28b7891917b4fda4004
https://doi.org/10.1038/sj.bjc.6603035
https://doi.org/10.1038/sj.bjc.6603035
Autor:
Lutz Müller, David Tweats, Gary M. Williams, David Kirkland, Leigh Henderson, James M. Parry, Daniel Marzin, Günter Speit
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 588:88-105
The European Scientific Committee on Cosmetics and Non-Food Products (SCCNFP) guideline for testing of hair dyes for genotoxic/mutagenic/carcinogenic potential has been reviewed. The battery of six in vitro tests recommended therein differs substanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83894d8564261376b45233207dbcfbd7
https://doi.org/10.1016/j.mrgentox.2005.09.006
https://doi.org/10.1016/j.mrgentox.2005.09.006