Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James M. Myslinski"'
Organic impurity profiling of fentanyl samples associated with recent clandestine laboratory methods
Autor:
Steven G. Toske, Jennifer R. Mitchell, James M. Myslinski, Andrew J. Walz, David B. Guthrie, Elizabeth M. Guest, Charlotte A. Corbett, Emily D. Lockhart
Publikováno v:
Journal of Forensic Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0283402882eb73cf26fb1753d2032f
https://doi.org/10.1111/1556-4029.15281
https://doi.org/10.1111/1556-4029.15281
Autor:
Caroline Langley, Sue Y Bae, Jonah Cheung, Scott D. Pegan, J.J. Height, Mark D Winemiller, Vanessa L Funk, Mark A. Guelta, J.R. McGuire, S.M. Bester, James M. Myslinski
Publikováno v:
Chemical Research in Toxicology. 34:804-816
The recent use of organophosphate nerve agents in Syria, Malaysia, Russia, and the United Kingdom has reinforced the potential threat of their intentional release. These agents act through their ability to inhibit human acetylcholinesterase (hAChE; E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c840e3110b59e82d39762b12fd214e
https://doi.org/10.1021/acs.chemrestox.0c00406
https://doi.org/10.1021/acs.chemrestox.0c00406
Autor:
James M. Myslinski, Christopher M. Timperley, Nicholas J. Cooper, Fu-Lian Hsu, Neil Roughley, Li Kong, Andrew J Walz, Tyler D. P. Goralski, Tim Rose, Michael G. Feasel
Publikováno v:
ACS Med Chem Lett
[Image: see text] Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl. The primary metabolites of carfentanil, generated from human liver microsomes, were structurally confirmed through chemical synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80f1787a3271f7f3fe0503bf41ab87f
https://doi.org/10.1021/acsmedchemlett.9b00404
https://doi.org/10.1021/acsmedchemlett.9b00404
Autor:
J.J. Height, Andrew N. Bigley, Leslie R. Mcmahon, James M. Myslinski, Steven P. Harvey, Sue Y. Bae, Frank M. Raushel
Publikováno v:
Enzyme and Microbial Technology. 112:65-71
The wild-type OPAA enzyme has relatively high levels of catalytic activity against several organophosphate G-type nerve agents. A series of mutants containing replacement amino acids at the OPAA Y212, V342, and I215 sites showed several fold enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19be2c3190aa7fa724576e7354b5634
https://doi.org/10.1016/j.enzmictec.2017.11.001
https://doi.org/10.1016/j.enzmictec.2017.11.001
Autor:
Paul T. Wilder, Kaylin A. Adipietro, David J. Weber, J.J. Height, Nicholas D. Keul, Scott D. Pegan, Vanessa L Funk, S.M. Bester, Zachary A. Wood, Jonah Cheung, James M. Myslinski
Publikováno v:
Protein Science : A Publication of the Protein Society
Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Hence, there is an active interest in studying the mechanism of inhibition and recovery of enzymatic activity, which could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1630ec7f71bf87abe99728917c68d356
https://pubmed.ncbi.nlm.nih.gov/30993792
https://pubmed.ncbi.nlm.nih.gov/30993792
Publikováno v:
International Journal of Drug Policy. 86:102939
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2beb680f293df295794a2947c0a23c
https://doi.org/10.1016/j.drugpo.2020.102939
https://doi.org/10.1016/j.drugpo.2020.102939
In order to probe the energetics associated with a putative cation-π interaction, thermodynamic parameters are determined for complex formation between the Grb2 SH2 domain and tripeptide derivatives of RCO–pTyr–Ac6c–Asn wherein the R group is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9668bff38e4d8916586853b3d3a105f6
https://europepmc.org/articles/PMC4077163/
https://europepmc.org/articles/PMC4077163/
Publikováno v:
ACS medicinal chemistry letters. 4(11)
Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and tripeptides of the general form Ac-pTyr-Xaa-Asn in which the Xaa residue bears a linear alkyl chain varying in length from 1–5 carbon atoms. Binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d144b9f033ce12d4317b411af7d918
https://pubmed.ncbi.nlm.nih.gov/24349642
https://pubmed.ncbi.nlm.nih.gov/24349642
Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and Ac-pTyr-Xaa-Asn derived tripeptides in which the Xaa residue is an α,α-cycloaliphatic amino acid that varies in ring size from three- to seven-membered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e977614d1c0a9b551455c589802fadbd
https://europepmc.org/articles/PMC3218293/
https://europepmc.org/articles/PMC3218293/