Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James M. Kesslick"'
Autor:
Joanne R. Mathiasen, M. J. Kukla, D. L. Barrett, Gregory E. Martin, James M. Kesslick, M. K. Scott, D. L. Distefano, C. L. Fedde, Richard P. Shank, J. L. Vaught, William J. Baldy, R. J. Jun. Elgin
Publikováno v:
ChemInform. 23
Autor:
M. J. Kukla, Mathiasen, Gregory E. Martin, Robert J. Elgin, C. L. Fedde, D. L. Distefano, D. L. Barrett, James M. Kesslick, William J. Baldy, M. K. Scott
Publikováno v:
Journal of medicinal chemistry. 35(3)
Recently, we reported on a series of arylpiperazines 4 which exhibit high affinity for the serotonin 5-HT-1A and 5-HT-1B binding sites. Although these compounds interact weakly with dopamine D-1 and D-2 receptors, they are reasonably potent in inhibi
Autor:
Gregory E. Martin, Malcolm K. Scott, William J. Baldy, Joanne R. Mathiasen, Robert J. Elgin, James M. Kesslick, Richard P. Shank
Publikováno v:
European Journal of Pharmacology. 156:223-229
Ortho-nethoxyphenylpiperazine (OMPP) and meta-substituted chlorophenylpiperazine (MCPP) blocked conditioned avoidance responding (CAR) in the rat ((ED 50 values = 5.6 (4.6, 7.3) and 2.4 (1.9, 2.9) mg/kg i.p. (95% confidence limits), respectively) wit
Autor:
Gregory E. Martin, Robert J. Elgin, Richard P. Shank, Joanne R. Mathiasen, Coralie B. Davis, William J. Baldy, Cynthia L. Fedde, James M. Kesslick, Deena L. DiStefano, Malcom K. Scott
Publikováno v:
Journal of Medicinal Chemistry. 32:1052-1056
Generally, antipsychotic agents are dopamine receptor blocking agents that also block conditioned avoidance responding (CAR) in the rat. Recently, however, both (Q-methoxyphenyl)piperazine (OMPP, 1h) and (m-chlorophenyl)piperazine (MCPP, 1o) have bee