Zobrazeno 1 - 10
of 255
pro vyhledávání: '"James M. Kelly"'
Autor:
Ruth Christine Winter, Mariam Amghar, Anja S. Wacker, Gábor Bakos, Harun Taş, Mareike Roscher, James M. Kelly, Martina Benešová-Schäfer
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1031 (2024)
Cancer is one of the most complex and challenging human diseases, with rising incidences and cancer-related deaths despite improved diagnosis and personalized treatment options. Targeted alpha therapy (TαT) offers an exciting strategy emerging for c
Externí odkaz:
https://doaj.org/article/cb8cc3ceddcb4530a7476bd0717f108c
A suitable time point for quantifying the radiochemical purity of 225Ac-labeled radiopharmaceuticals
Autor:
James M. Kelly, Alejandro Amor-Coarasa, Elizabeth Sweeney, Justin J. Wilson, Patrick W. Causey, John W. Babich
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Background As 225Ac-labeled radiopharmaceuticals continue to show promise as targeted alpha therapeutics, there is a growing need to standardize quality control (QC) testing procedures. The determination of radiochemical purity (RCP) is an e
Externí odkaz:
https://doaj.org/article/c59c17ba332543ec9ee3b46b82a49a5a
Publikováno v:
Translational Oncology, Vol 22, Iss , Pp 101450- (2022)
The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA. Theranostic
Externí odkaz:
https://doaj.org/article/1b2c96b4f70244afb417a188da40e024
Autor:
James M. Kelly, Thomas M. Jeitner, Nicole N. Waterhouse, Wenchao Qu, Ethan J. Linstad, Banafshe Samani, Clarence Williams, Anastasia Nikolopoulou, Alejandro Amor-Coarasa, Stephen G. DiMagno, John W. Babich
Publikováno v:
Molecules, Vol 27, Iss 5, p 1552 (2022)
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis. Fatty acid synthase (FASN) is t
Externí odkaz:
https://doaj.org/article/3c359e76b2464d68aabac98b8253548d
Autor:
Alejandro Amor-Coarasa, James M. Kelly, Pradeep K. Singh, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Yogindra Vedvyas, Moonsoo M. Jin, J. David Warren, John W. Babich
Publikováno v:
Molecules, Vol 24, Iss 8, p 1612 (2019)
Determining chemokine receptor CXCR4 expression is significant in multiple diseases due to its role in promoting inflammation, cell migration and tumorigenesis. [68Ga]Pentixafor is a promising ligand for imaging CXCR4 expression in multiple tumor typ
Externí odkaz:
https://doaj.org/article/5a56847e5c1d40c8832a2599259bda54
Autor:
Alejandro Amor-Coarasa, James M. Kelly, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, John W. Babich
Publikováno v:
Molecules, Vol 23, Iss 10, p 2575 (2018)
Emerging interest in extending the plasma half-life of small molecule radioligands warrants a consideration of the appropriate radionuclide for PET imaging at longer time points (>8 h). Among candidate positron-emitting radionuclides, 66Ga (t1/2 = 9.
Externí odkaz:
https://doaj.org/article/c5719628961c425485cc6e0dddb22e39
Autor:
Thomas M. Jeitner, Juan A. Azcona, Gene P. Ables, Diana Cooke, Mark C. Horowitz, Pradeep Singh, James M. Kelly, Arthur J. L. Cooper
Publikováno v:
GeroScience.
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the trans
Autor:
Thomas M. Jeitner, James M. Kelly
Publikováno v:
Analytical biochemistry. 657
Mammalian transglutaminase 2 exhibits poor long-term stability in solution. Reconstituting lyophilized transglutaminase 2 in solutions containing dithiothreitol and EDTA alone and together with glycerol stabilizes the activity of this enzyme for seve
Autor:
Paul S. Donnelly, John W. Babich, Shashikanth Ponnala, James M. Kelly, Stephen G. DiMagno, Nicholas Zia, Alejandro Amor-Coarasa, David J. Schlyer, Clarence Williams, Anastasia Nikolopoulou
Publikováno v:
Molecular Pharmaceutics. 17:1954-1962
The application of small molecules targeting prostate-specific membrane antigen (PSMA) has emerged as a highly promising clinical strategy for visualization and treatment of prostate cancer. Ligands that integrate the ability to both quantify the dis
Autor:
James M. Kelly, John W. Babich
Publikováno v:
Current cardiology reports. 24(3)
Purpose of ReviewSuccessful treatment of cancer can be hampered by the attendant risk of cardiotoxicity, manifesting as cardiomyopathy, left ventricle systolic dysfunction and, in some cases, heart failure. This risk can be mitigated if the injury to