Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James M. Grace"'
Autor:
James M. Grace, Thomas G. Brewer, Alan L. Mitchell, Kathleen U. Leo, Jim O. Peggins, Tony Aguilar, Qigui Li
Publikováno v:
Pharmacology. 54:276-284
Arteether (AE) is primarily deethylated to dihydroqinghaosu (DQHS) in rats and humans. Conversion of AE to DQHS was impaired in microsomes from rats infected with Plasmodium berghei. The Km for AE was 175.1 +/- 49.1 and 124.4 +/- 115.1 mumol/l, and V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312104b0ab80aeff6a4ce61e8a289e00
https://doi.org/10.1159/000139496
https://doi.org/10.1159/000139496
Publikováno v:
Pharmaceutical Research. 14:1449-1454
Purpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41046de0ff8133af9370dee586d4185
https://doi.org/10.1023/a:1012185124972
https://doi.org/10.1023/a:1012185124972
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1643-1648
Amonafide (4-aminobenzoisoqinolinedione) and its structural analog, mitonafide 1 , have been shown to stabilize topoisomerase II cleavable complexes. The position of the nitro group and structural modifications of the side chain influence the interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b8281eb581b9dd93ff0c2669da4c4ba
https://doi.org/10.1016/s0960-894x(01)80582-5
https://doi.org/10.1016/s0960-894x(01)80582-5
Publikováno v:
Chemical Research in Toxicology. 7:286-290
Debrisoquine 4-hydroxylase is a unique cytochrome P450 that effects oxidation of protonated substrates at sites distal from the basic nitrogen. A basic tenet of the several models that have been proposed for the active site of P450 2D6 is that oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37901751ecf89851cd54c2cef530dca2
https://doi.org/10.1021/tx00039a003
https://doi.org/10.1021/tx00039a003
Autor:
Steven L. Andersen, Jonathan L. Vennerstrom, Joanna K. Hu, James M. Grace, Arba L. Ager, Varima Wongpanich, David L. Wesche, Cindy K. Angerhofer
Publikováno v:
The American journal of tropical medicine and hygiene. 62(5)
The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8baff24c5ed7292dab1eef7ad2cf7d
https://pubmed.ncbi.nlm.nih.gov/11289666
https://pubmed.ncbi.nlm.nih.gov/11289666
Publikováno v:
Clinical pharmacokinetics. 39(4)
Various compounds of the artemisinin family are currently used for the treatment of patients with malaria worldwide. They are characterised by a short half-life and feature the most rapidly acting antimalarial drugs to date. They are increasingly bei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b26c1ae2113a5788f1cbb24c1fe789
https://pubmed.ncbi.nlm.nih.gov/11069212
https://pubmed.ncbi.nlm.nih.gov/11069212
Publikováno v:
Free radical research. 25(1)
Products of the reaction of 4-hydroxy-2-nonenal (4HNE) with native and heat-denatured Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase (G6PDH) were analyzed to determine the structure and position of the protein modifications. Matrix assis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130bab1a6043f2aa862d70e8222ec47d
https://pubmed.ncbi.nlm.nih.gov/8814441
https://pubmed.ncbi.nlm.nih.gov/8814441