Zobrazeno 1 - 10
of 20
pro vyhledávání: '"James M. Gavin"'
Autor:
Keli Song, James Minissale, Richard A. Klinghoffer, James Garnsey, Katherine Galvin, Kristina Xega, Sai M Pulukuri, James M. Gavin, Xiaofeng Yang, Pooja Shah, Gary Shapiro, Cong Li, Vaishali Shinde, Eric S. Lightcap, Dennis Huszar, Zhen Lu, Stephen Grossman, Erik Koenig, Pengfei Yu, Steve Langston, Hisashi Imaichi, Serge Y. Fuchs, Mithun Khattar, Beryl A. Hatton, Yu Fu, Hongru Zhang, Dylan England, Michael Milhollen, Jessica Riceberg, Xingyue He
Publikováno v:
Sci Transl Med
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small molecule inhibitor of SUMOylation, pharmacologi
Autor:
Kara Hoar, Jiejin Chen, Sean J. Harrison, Jingya Ma, James M. Gavin, Neil F. Bence, Wei Chen, Ping Li, Michael Sintchak, Nancy J. Bump, Qing Xu, Lawrence R. Dick, William D. Mallender, Jesse J. Chen, Alexandra E. Gould, Frank Bruzzese, Yafang Lin
Publikováno v:
Journal of Biological Chemistry. 289:22648-22658
E1 enzymes activate ubiquitin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascade of Ubl conjugation to target proteins or lipids. Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and
Autor:
John Newcomb, James M. Gavin, Nancy J. Bump, Stephen Tirrell, Lawrence R. Dick, Saurabh Menon, Jessica Huck, Petter Veiby, Benjamin S. Amidon, Yu Yang, Marc L. Hyer, Paul D. Greenspan, Fleming Paul E, Teresa A. Soucy, Jim Brownell, Michael Sintchak, Josh Powe, Steve Langston, Mark Manfredi, Judy Shi, Jeff Ciavarri, Darshan S. Sappal, Frank Bruzzese, Mike Kuranda, Katherine Galvin, Michael Milhollen, Ping Li, Neil F. Bence, Jing Tao Wu, Claudia Rabino, Chris Claiborne, Tary Traore, Jennifer Duffy, Jessica Riceberg, Robert J. Griffin, Kara Hoar, Anya Lublinsky, Bradley Stringer, Sai M Pulukuri
Publikováno v:
Nature medicine. 24(2)
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulator
Autor:
Lawrence R. Dick, Hua Liao, Neil Rollins, Xiaofeng Yang, William D. Mallender, Qing Xu, James E. Brownell, James M. Gavin, Jingyang Chen, Alexandra E. Gould, Huay-Keng Loke, Jingya Ma, Trupti Lingaraj, Benjamin S. Amidon
Publikováno v:
Journal of Biological Chemistry. 287:15512-15522
Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. In this study, biochemical and biophysical experiments were performed to understand the mechanisms of how Uba6 recogniz
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Autor:
Larry Dick, Virendar K. Kaushik, Thomas F. Parsons, Peter J. Tummino, Susan L. Acton, Michael A. Patane, Kevin Godbout, Jin Tang, Elizabeth Baronas, Chad S Vickers, Frank Y. Hsieh, James M. Gavin, Paul Hales, Andrew J. Nichols
Publikováno v:
Journal of Biological Chemistry. 277:14838-14843
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its catalytic activit
Autor:
Frank J, Bruzzese, Michael A, Milhollen, James M, Gavin, Helen R, Josephine, James E, Brownell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 832
The NEDD8 conjugation pathway is initiated by the NEDD8 E1, also known as NEDD8 activating enzyme (NAE) or APPBP1/UBA3 (Gong, Yeh. J Biol Chem 274:12063-12042, 1999). The best described biological role for NEDD8 conjugation is to regulate the activit
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794735
The NEDD8 conjugation pathway is initiated by the NEDD8 E1, also known as NEDD8 activating enzyme (NAE) or APPBP1/UBA3 (Gong, Yeh. J Biol Chem 274:12063-12042, 1999). The best described biological role for NEDD8 conjugation is to regulate the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74968cc19dc75958ed74cfc5ba6e5f19
https://doi.org/10.1007/978-1-61779-474-2_40
https://doi.org/10.1007/978-1-61779-474-2_40
Autor:
Xiaofeng Yang, Michael Milhollen, Neil Bence, Mark Manfredi, Huay-Keng Loke, Erik Koenig, James E. Brownell, Mike Sintchak, Michael P. Thomas, Usha Narayanan, Qing Xu, James M. Gavin, Jessica Riceberg, Alice McDonald, Joseph B. Bolen, Benjamin S. Amidon, Peter G. Smith, Sells Todd B, Tary Traore, Jingya Ma, Lawrence R. Dick
Publikováno v:
Cancer cell. 21(3)
SummaryMLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer. MLN4924 is a mechanism-based inhibitor, with enzyme inhibition occurring through the formation of a tight-b
Autor:
Anne L. Burkhardt, Michael Milhollen, Xiaofeng Yang, Huay-Keng Loke, Lawrence R. Dick, Teresa A. Soucy, Irache Visiers, Frank J. Bruzzese, Michael D. Sintchak, James J. Spelman, Steven P. Langston, Ping Li, Kristin B. Hamman, James M. Gavin, Joseph B. Bolen, Nancy Bump, Sells Todd B, Jingya Ma, Christopher F. Claiborne, Stepan Vyskocil, Courtney Cullis, Hua Liao, Mark Rolfe, Dongyun Wu, James E. Brownell, Trupti Lingaraj, William D. Mallender
Publikováno v:
Molecular cell. 37(1)
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical trials for the treatment of cancer. Here, we show that MLN4924 is a