Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James M. Fay"'
Autor:
Cheng Zhu, Elena Dukhovlinova, Olivia Council, Lihua Ping, Edgar M. Faison, Shamit S. Prabhu, E. Lake Potter, Stephen L. Upton, Guowei Yin, James M. Fay, Laura P. Kincer, Ean Spielvogel, Sharon L. Campbell, S. Rahima Benhabbour, Hengming Ke, Ronald Swanstrom, Nikolay V. Dokholyan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.
Externí odkaz:
https://doaj.org/article/e4e26a3dfbec4915bf069d55e9f14cb0
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1391 (2022)
Many therapeutic formulations incorporate poly(ethylene glycol) (PEG) as a stealth component to minimize early clearance. However, PEG is immunogenic and susceptible to accelerated clearance after multiple administrations. Here, we present two novel
Externí odkaz:
https://doaj.org/article/fa92507a094e4bd9bf1a327aab30b8f8
Autor:
James M. Fay, Alexander V. Kabanov, Mengzhe Wang, Matthew J. Haney, Hwang Duhyeong, Elena V. Batrakova, Hui Wang, Yueh Z. Lee, Zibo Li, Yuling Zhao, Mohan Kumar Muthu Karuppan, Nazira El-Hage
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Cell-based drug delivery systems have generated an increasing interest in recent years. We previously demonstrated that systemically administered macrophages deliver therapeutics to CNS, including glial cell line-derived neurotrophic factor (GDNF), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11d13a55dbaf5d8885fc4753e13f512
http://link.springer.com/article/10.1038/s41598-020-68874-7
http://link.springer.com/article/10.1038/s41598-020-68874-7
Autor:
S. Rahima Benhabbour, Guowei Yin, Laura P. Kincer, Elena Dukhovlinova, Shamit S. Prabhu, Edgar M. Faison, Cheng Zhu, Li-Hua Ping, Sharon L. Campbell, Ronald Swanstrom, Nikolay V. Dokholyan, Hengming Ke, Stephen L. Upton, Ean Spielvogel, E. Lake Potter, James M. Fay
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
An array of carbohydrates masks the HIV-1 surface protein Env, contributing to the evasion of humoral immunity. In most HIV-1 isolates ‘glycan holes’ occur due to natural sequence variation, potentially revealing the underlying protein surface to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca4dafebba2950b73b1304f98fc07f8
https://doi.org/10.1038/s41467-019-08876-w
https://doi.org/10.1038/s41467-019-08876-w
Autor:
Xiang Yi, Natasha Vinod, Yuhang Jiang, William A. Banks, Alexander V. Kabanov, Kristin M. Bullock, Devika S. Manickam, Si Qin, Yuling Zhao, Chi-Duen Poon, James M. Fay
Publikováno v:
Advanced functional materials. 28(6)
Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and rapid brain clearance. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d2ffabbb4db6bd6a05ea262966c082
https://pubmed.ncbi.nlm.nih.gov/29785179
https://pubmed.ncbi.nlm.nih.gov/29785179
Publikováno v:
Scientific Reports
Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9f1f0e277ea0ab8f26c3db395e71e4
http://europepmc.org/articles/PMC5314451
http://europepmc.org/articles/PMC5314451
Publikováno v:
Biochemistry
Accumulating evidence supports a prominent contribution of misfolding and aggregation of SOD1 to the dysfunction and progressive death of motor neurons in ALS. Over 140 mutations (mostly missense) in the SOD1 gene have been identified in patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73620893f032caa7c4b25faf0655eaff
https://doi.org/10.1021/bi500158w
https://doi.org/10.1021/bi500158w
Publikováno v:
Scientific Reports
Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6873cea4db6aa0e0fb03f8dbf5cedc19
Autor:
Nikolay V. Dokholyan, James M. Fay, Elizabeth A. Proctor, Ian P. Mercer, Yazhong Tao, Zhengjian Lv, Yuliang Zhang, Rachel L. Redler, Lanette Fee, Yuri L. Lyubchenko, Mohanish Deshmukh
Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the connection between SOD1 and motor neuron death. Disease-linked mutations tend to destabilize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70856998e701191078e1a2c45b1a3420
https://europepmc.org/articles/PMC4725519/
https://europepmc.org/articles/PMC4725519/
Autor:
Connie C.W. Hsia, Ruchi Goel, Robert L. Johnson, Harrieth Wagner, Peter D. Wagner, James M. Fay
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 89(1)
The carotenoid compound crocetin has been hypothesized to enhance the diffusion of O2 through plasma, and observations in the rat and rabbit have revealed improvement in arterial Po 2 when crocetin is given. To determine whether crocetin enhances dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e73f61fa5346caeb310b462845ffa06
https://pubmed.ncbi.nlm.nih.gov/10904057
https://pubmed.ncbi.nlm.nih.gov/10904057