BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode

Autor: James M. Dunce, Owen R. Davies

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract BRCA2 is essential for DNA repair by homologous recombination in mitosis and meiosis. It interacts with recombinases RAD51 and DMC1 to facilitate the formation of nucleoprotein filaments on resected DNA ends that catalyse recombination-media

Externí odkaz: https://doaj.org/article/d45ff3f8aa994eef9e7fcb38cfda5435

Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Autor: James M. Dunce, Lucy J. Salmon, Owen R. Davies

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of it

Externí odkaz: https://doaj.org/article/780b79bce53f4a619c1cf35883f45d85

Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3

Autor: James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies

Publikováno v: Crichton, J, Dunce, J M, Dunne, O M, Salmon, L, Devenney, P S, Lawson, J, Adams, I R & Davies, O 2023, ' Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 ', Nature Structural & Molecular Biology . https://doi.org/10.1038/s41594-022-00909-1

In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an SYCP1 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683a5976d6e39069e7495a4f2a6ccf09
https://doi.org/10.1038/s41594-022-00909-1

Structural maturation of SYCP1-mediated meiotic chromosome synapsis through conformational remodelling by molecular adapter SYCE3

Autor: James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies

In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an SYCP1 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c925610beb13feec98f7f44f1710c261
https://doi.org/10.1101/2022.03.06.483192

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly

Autor: Isabel Usón, Owen R. Davies, Claudia Millán, Suzanne Madgwick, James M. Dunce, Orla M. Dunne, Matthew Ratcliff

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are bound together in homologous chromosome pairs by a supramolecular protein assembly, the synaptonemal complex. This three-dimensional scaffold provides the essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4d4a81410a6830e296698f86aa8f15
http://hdl.handle.net/10261/242140