Výsledky vyhledávání - "James M. Davison"

Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer - The Piedmont Study

Autor: Joel R. Eisner, Gregory M. Mayhew, James M. Davison, Kirk D. Beebe, Yoichiro Shibata, Yuelong Guo, Carol Farhangfar, Farhang Farhangfar, Joshua M. Uronis, Jeffrey M. Conroy, Michael V. Milburn, David Neil. Hayes, Kathryn F. Mileham

Publikováno v: Clinical Cancer Research.

Purpose: The Piedmont study is a prospectively designed retrospective evaluation of a new 48-gene antifolate response signature (AF-PRS) in patients with locally advanced/metastatic NS-NSCLC treated with pemetrexed-containing platinum doublet chemoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43c4953b0bb03f5b73d0ac32e56d115c
https://doi.org/10.1158/1078-0432.ccr-22-2558

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Real-world data validation of the PurIST pancreatic ductal adenocarcinoma gene expression classifier and its prognostic implications

Autor: Stephane Wenric, James M. Davison, John Guittar, Gregory M. Mayhew, Kirk D. Beebe, Yun E. Wang, Amrita A. Iyer, Hyunseok P. Kang, Michael V. Milburn, Vincent Chung, Tanios Bekaii-Saab, Charles M. Perou

BackgroundPancreatic ductal adenocarcinoma (PDAC) is amongst the deadliest cancers, with few modern tools to inform patient prognosis and help guide treatment options. Transcriptome-based molecular subtyping is one emerging technology that has been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe5f2a6c4b61b76f6b921ebceead1bf2
https://doi.org/10.1101/2023.02.23.23286356

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Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function

Autor: Jennifer K Heppert, Colin R Lickwar, Matthew C Tillman, Briana R Davis, James M Davison, Hsiu-Yi Lu, Wei Chen, Elisabeth M Busch-Nentwich, David L Corcoran, John F Rawls

Publikováno v: Genetics. 222(4)

Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors are liganded transcription fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31298d79bdfe881cd464ff5aa484724f
https://pubmed.ncbi.nlm.nih.gov/36218393

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Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium

Autor: Cecelia Kelly, James M. Davison, Gilberto Padilla Mercado, John F. Rawls, Jennifer K. Heppert, Colin R. Lickwar

Publikováno v: Nat Rev Gastroenterol Hepatol

The intestinal epithelium serves the unique and critical function of harvesting dietary nutrients, while simultaneously acting as a cellular barrier separating tissues from the luminal environment and gut microbial ecosystem. Two salient features of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23368c7bba449381146f8b0c9bbd350a
https://doi.org/10.1038/s41575-020-00357-6

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Transcriptional integration of distinct microbial and nutritional signals by the small intestinal epithelium

Autor: Colin R. Lickwar, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Jia Wen, Briana R. Davis, Matthew C. Tillman, Ivana Semova, Sarah F. Andres, Goncalo Vale, Jeffrey G. McDonald, John F. Rawls

The intestine constantly interprets and adapts to complex combinations of dietary and microbial stimuli. However, the transcriptional strategies by which the intestinal epithelium integrates these coincident sources of information remain unresolved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768bc37cbe5dd8278b25eeab3863415a
https://doi.org/10.1101/2021.11.01.465976

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Abstract A002: Purity Independent Subtyping of Tumor (PurIST): Real-world data validation of a pancreatic ductal adenocarcinoma (PDAC) gene expression classifier and its prognostic implications

Autor: Stephane Wenric, James M. Davison, Yun E. Wang, Gregory M. Mayhew, Kirk Beebe, Hyunseok P. Kang, Michael V. Milburn, Vincent Chung, Tanios Bekaii-Saab, Charles M. Perou

Publikováno v: Cancer Research. 82:A002-A002

Background: PDAC is a highly morbid disease with no validated biomarkers for first-line (1L) treatment selection. The PurIST single-sample molecular subtyping gene signature, initially described by Rashid et al. (Clin. Cancer Res., 2020), classifies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdfe738dcbb3d20b6f0b44a9fb92b791
https://doi.org/10.1158/1538-7445.panca22-a002

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Probiotic and synbiotic therapy in the critically ill: State of the art

Autor: Paul E. Wischmeyer, James M. Davison

Publikováno v: Nutrition. 59:29-36

Recent medical history has largely viewed our bacterial symbionts as pathogens to be eradicated rather than as essential partners in optimal health. However, one of the most exciting scientific advances in recent years has been the realization that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b43d2b6346033a091557cc710407d3
https://doi.org/10.1016/j.nut.2018.07.017

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Detailed immunogenomic analysis of high dose IL-2 pharmacodynamic effects: A benchmark for next-generation IL-2-based immunotherapies

Autor: Kirk Beebe, Joel Robert Eisner, Yoichiro Shibata, James M Davison, John Guo, Carol J. Farhangfar, Farhang Farhangfar, Joshua M. Uronis, Jill Mooney, Michael Vance Milburn, David Foureau, Richard L. White, Asim Amin, Marcos E Milla

Publikováno v: Journal of Clinical Oncology. 40:e16501-e16501

e16501 Background: High-dose interleukin-2 (HD IL-2) was the first approved immune-oncology (IO) agent based on proven clinical efficacy in renal cell carcinoma (RCC) and metastatic melanoma, but its use was limited due to significant toxicities. Mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94c31c7cb7026b1e1eb92611aaee04b8
https://doi.org/10.1200/jco.2022.40.16_suppl.e16501

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Abstract PO-002: Initial retrospective analysis of mechanisms of FOLFIRINOX resistance using clinical and molecular data from the Know Your Tumor (KYT) pancreatic ductal adenocarcinoma (PDAC) cohort

Autor: James M. Davison, Dennis Ladnier, Lynn M. Matrisian, Kirk Beebe, Eric A. Collisson, Greg Mayhew, Joel R. Eisner

Publikováno v: Cancer Research. 81:PO-002

Introduction: The Know Your Tumor (KYT) pancreas cancer program enables molecular analysis of both tumor DNA and mRNA to characterize tumor phenotypes and guide potential treatment options. The primary objective of the current study was to develop an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b1138dd8c8e89e89caf74f17c78cec4
https://doi.org/10.1158/1538-7445.panca21-po-002

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Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha

Autor: James M. Davison, Colin R. Lickwar, John F. Rawls, Greg E. Crawford, Ghislain Breton, Lingyun Song

Publikováno v: Genome Research. 27:1195-1206

Microbiota influence diverse aspects of intestinal physiology and disease in part by controlling tissue-specific transcription of host genes. However, host genomic mechanisms mediating microbial control of intestinal gene expression are poorly unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac52dd9f7006edf1a046eee4e8f80eb
https://doi.org/10.1101/gr.220111.116

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