Zobrazeno 1 - 10
of 33
pro vyhledávání: '"James M. Clomburg"'
Autor:
Bastian Vögeli, Luca Schulz, Shivani Garg, Katia Tarasava, James M. Clomburg, Seung Hwan Lee, Aislinn Gonnot, Elamar Hakim Moully, Blaise R. Kimmel, Loan Tran, Hunter Zeleznik, Steven D. Brown, Sean D. Simpson, Milan Mrksich, Ashty S. Karim, Ramon Gonzalez, Michael Köpke, Michael C. Jewett
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
An attractive route for carbon-negative synthesis of biochemical products is the reverse β-oxidation pathway coupled to the Wood-Ljungdahl pathway. Here the authors use a high-throughput in vitro prototyping workflow to screen 762 unique pathway com
Externí odkaz:
https://doaj.org/article/2db1bcf195d34b60b46738910cf4f33f
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 1, Pp 289-304 (2022)
Summary Most microorganisms can metabolize glycerol when external electron acceptors are available (i.e. under respiratory conditions). However, few can do so under fermentative conditions owing to the unique redox constraints imposed by the high deg
Externí odkaz:
https://doaj.org/article/1f23c554dbe147a090e1fe79012d108d
Publikováno v:
Nature Catalysis. 3:593-603
Polyketides found in nature originate from backbones synthesized through iterative decarboxylative Claisen condensations catalysed by polyketide synthases (PKSs). However, PKSs suffer from complicated architecture, energy inefficiencies, complex regu
Publikováno v:
Nature Chemical Biology. 15:900-906
Despite the potential of biotechnological processes for one-carbon (C1) bioconversion, efficient biocatalysts required for their implementation are yet to be developed. To address intrinsic limitations of native C1 biocatalysts, here we report that 2
Publikováno v:
Nature metabolism. 3(10)
Metabolic engineering often entails concurrent engineering of substrate utilization, central metabolism and product synthesis pathways, inevitably creating interdependency with native metabolism. Here we report an alternative approach using synthetic
Publikováno v:
ACS Synthetic Biology. 7:1886-1896
Type III polyketide synthases (PKS IIIs) contribute to the synthesis of many economically important natural products, most of which are currently produced by direct extraction from plants or through chemical synthesis. Olivetolic acid (OLA) is a plan
Publikováno v:
Metabolic Engineering. 45:11-19
An engineered reversal of the β-oxidation cycle (r-BOX) and the fatty acid biosynthesis (FAB) pathway are promising biological platforms for advanced fuel and chemical production in part due to their iterative nature supporting the synthesis of vari
Publikováno v:
Nature chemical biology. 15(9)
Despite the potential of biotechnological processes for one-carbon (C1) bioconversion, efficient biocatalysts required for their implementation are yet to be developed. To address intrinsic limitations of native C1 biocatalysts, here we report that 2
Publikováno v:
Biotechnology and bioengineering. 116(5)
Prenylated aromatics (PAs) are an important class of natural products with valuable pharmaceutical applications. To address current limitations of their sourcing from plants, here, we present a microbial platform for the in vivo synthesis of PAs base
Publikováno v:
Journal of industrial microbiologybiotechnology. 45(6)
Convergence of market drivers such as abundant availability of inexpensive natural gas and increasing awareness of its global warming effects have created new opportunities for the development of small-scale gas-to-liquid (GTL) conversion technologie