Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James M. Clinton"'
Publikováno v:
Current Protocols in Cell Biology. 82
Organoids are primary patient-derived micro tissues grown within a three-dimensional extracellular matrix that better represents in vivo physiology and genetic diversity than existing two-dimensional cell lines. Organoids rely on the self-renewal and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97111853a4edb9f30cf145e22c4dd41c
https://doi.org/10.1002/cpcb.66
https://doi.org/10.1002/cpcb.66
Publikováno v:
Cancer Research. 79:51-51
Three-dimensional “organoid” growth of tumors may represent a more physiologically relevant in vitro model system than traditional two-dimensional monolayer cultures of cancer cell lines. With the increased availability of cryopreserved human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef42cb34a47ab0b72ad113c0d3a16e8
https://doi.org/10.1158/1538-7445.am2019-51
https://doi.org/10.1158/1538-7445.am2019-51
Publikováno v:
European Journal of Neuroscience. 35:1789-1798
Adenosine and extracellular adenosine triphosphate (ATP) have multiple physiological central nervous system actions including regulation of cerebral blood flow, inflammation and sleep. However, their exact sleep regulatory mechanisms remain unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743c13661fd3160eac22031b93d9bbf4
https://doi.org/10.1111/j.1460-9568.2012.08112.x
https://doi.org/10.1111/j.1460-9568.2012.08112.x
Autor:
Fan Liao, Omar Bayomy, Christopher J. Davis, Mark R. Zielinski, Ping Taishi, James M. Krueger, Dirk E. Smith, James M. Clinton
Publikováno v:
Journal of Applied Physiology. 112:1015-1022
Interleukin (IL)-1β is involved in several brain functions, including sleep regulation. It promotes non-rapid eye movement (NREM) sleep via the IL-1 type I receptor. IL-1β/IL-1 receptor complex signaling requires adaptor proteins, e.g., the IL-1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a60da25a97067fa4447e2b0a126552
https://doi.org/10.1152/japplphysiol.01307.2011
https://doi.org/10.1152/japplphysiol.01307.2011
Autor:
Alok De, Éva Szentirmai, Christopher J. Davis, Ping Taishi, James M. Clinton, Bradley D. Winters, James M. Krueger, Mark R. Zielinski
Publikováno v:
Journal of Applied Physiology. 109:1318-1327
Sleep is dependent upon prior brain activities, e.g., after prolonged wakefulness sleep rebound occurs. These effects are mediated, in part, by humoral sleep regulatory substances such as cytokines. However, the property of wakefulness activity that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c74fdf638d6dc86293a1f76879a7cec
https://doi.org/10.1152/japplphysiol.00586.2010
https://doi.org/10.1152/japplphysiol.00586.2010
Autor:
Robert Newman, Dezhong Yin, Penney McWilliams-Koeppen, Siddhartha Paul, Allison Ruchinskas, James M. Clinton
Publikováno v:
Cancer Research. 78:5012-5012
To meet the need for improved approaches to study cancer in vitro, there has been a surge in the development of novel research models utilizing advanced culture methods. These methods permit in vitro growth of cancer types previously not possible, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0192d6b7e306011bfbcc9613f5b1f3e8
https://doi.org/10.1158/1538-7445.am2018-5012
https://doi.org/10.1158/1538-7445.am2018-5012
Sleep deprivation was previously reported to alter microRNA (miRNA) levels in the brain; however, the direct effects of any miRNA on sleep have only been described recently. We determined miRNA 138 (miR-138), miRNA let-7b (let-7b), and miRNA 125a-5p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2036dfb8c537800ac51d67a81cf4b151
https://europepmc.org/articles/PMC3544506/
https://europepmc.org/articles/PMC3544506/
Publikováno v:
The European journal of neuroscience. 35(11)
Adenosine and extracellular adenosine triphosphate (ATP) have multiple physiological central nervous system (CNS) actions including regulation of cerebral blood flow, inflammation, and sleep. However, their exact sleep regulatory mechanisms remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bc40f86f178b91c30db8d2f11a97544
https://pubmed.ncbi.nlm.nih.gov/22540145
https://pubmed.ncbi.nlm.nih.gov/22540145
Autor:
Christopher J. Davis, Kathryn A. Jewett, James M. Krueger, Mark R. Zielinski, James M. Clinton
Symptoms commonly associated with sleep loss and chronic inflammation include sleepiness, fatigue, poor cognition, enhanced sensitivity to pain and kindling stimuli, excess sleep and increases in circulating levels of tumor necrosis factor α (TNF) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1802c90bdac4281d8e3e86b46155f6a2
https://europepmc.org/articles/PMC3190410/
https://europepmc.org/articles/PMC3190410/
Autor:
James M. Krueger, James M. Clinton, Kathryn A. Jewett, Bradley D. Winters, Christopher J. Davis, Ping Taishi, Mark R. Zielinski
Publikováno v:
Progress in brain research. 193
Cytokines such as tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL1β) play a role in sleep regulation in health and disease. TNFα or IL1β injection enhances non-rapid eye movement sleep. Inhibition of TNFα or IL1β reduces spontaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553668fc8c5a94e1291e1d994464c749
https://pubmed.ncbi.nlm.nih.gov/21854954
https://pubmed.ncbi.nlm.nih.gov/21854954