Zobrazeno 1 - 10
of 324
pro vyhledávání: '"James M. Cheverud"'
Autor:
Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik, James M. Cheverud, Ophir D. Klein, Ramon Y. Birnbaum, Amy E. Merrill, Rebecca R. Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D. Forkert, Stephen A. Murray, Henrik Westerberg, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-18 (2022)
Abstract Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools f
Externí odkaz:
https://doaj.org/article/7defe75069d24f29bca1c5a94da00059
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101615- (2022)
Introduction: Knowledge of bone structure-function relationships in mice has been based on relatively small sample sets that limit generalizability. We sought to investigate structure-function relationships of long bones from a large population of ge
Externí odkaz:
https://doaj.org/article/797464590eae4827812ee6b482256b7a
Autor:
Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik, James M. Cheverud, Ophir D. Klein, Ramon Y. Birnbaum, Amy E. Merrill, Rebecca R. Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D. Forkert, Stephen A. Murray, Henrik Westerberg, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/be08db417e494e3e9e3dd747d51524cb
Autor:
Madeline Rose Keleher, Rabab Zaidi, Lauren Hicks, Shyam Shah, Xiaoyun Xing, Daofeng Li, Ting Wang, James M. Cheverud
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background While the genetics of obesity has been well defined, the epigenetics of obesity is poorly understood. Here, we used a genome-wide approach to identify genes with differences in both DNA methylation and expression associated with a
Externí odkaz:
https://doaj.org/article/d32dbb300d8743a4a2a34fda4a1ec803
Autor:
Rebecca M. Green, Jennifer L. Fish, Nathan M. Young, Francis J. Smith, Benjamin Roberts, Katie Dolan, Irene Choi, Courtney L. Leach, Paul Gordon, James M. Cheverud, Charles C. Roseman, Trevor J. Williams, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in c
Externí odkaz:
https://doaj.org/article/4cead5cb41ca4d3196d3cbf94d5c65c2
Autor:
Ehiole Akhirome, Suk D. Regmi, Rachel A. Magnan, Nelson Ugwu, Yidan Qin, Claire E. Schulkey, James M. Cheverud, Patrick Y. Jay
Publikováno v:
Genes, Vol 12, Iss 9, p 1368 (2021)
In newborns, severe congenital heart defects are rarer than mild ones. This epidemiological relationship between heart defect severity and incidence lacks explanation. Here, an analysis of ~10,000 Nkx2-5+/− mice from two inbred strain crosses illus
Externí odkaz:
https://doaj.org/article/e8d8dd38cbd14c9398caca17839fd729
Autor:
Nicholas G. Schultz, Jesse Ingels, Andrew Hillhouse, Keegan Wardwell, Peter L. Chang, James M. Cheverud, Cathleen Lutz, Lu Lu, Robert W. Williams, Matthew D. Dean
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 5, Pp 1141-1151 (2016)
The rapid divergence of male genitalia is a preeminent evolutionary pattern. This rapid divergence is especially striking in the baculum, a bone that occurs in the penis of many mammalian species. Closely related species often display diverse baculum
Externí odkaz:
https://doaj.org/article/56bf97ef74b14bdb9318f58ea1c28e8e
Publikováno v:
Symmetry, Vol 7, Iss 1, Pp 146-163 (2015)
Fluctuating asymmetry (FA), typically measured by variation in the differences between right and left sides of bilateral traits, is commonly used to assess developmental instability (DI) in populations. A previous quantitative trait locus (QTL) inves
Externí odkaz:
https://doaj.org/article/20c7987b66284a40966322487e178b66
Autor:
Heather A. Lawson, Kathleen M. Zelle, Gloria L. Fawcett, Bing Wang, L. Susan Pletscher, Taylor J. Maxwell, Thomas H. Ehrich, Jane P. Kenney-Hunt, Jason B. Wolf, Clay F. Semenkovich, James M. Cheverud
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 2976-2984 (2010)
Variation in serum cholesterol, free-fatty acids, and triglycerides is associated with cardiovascular disease (CVD) risk factors. There is great interest in characterizing the underlying genetic architecture of these risk factors, because they vary g
Externí odkaz:
https://doaj.org/article/7036436aa0c54a2290ef5df5a74bbaac
Autor:
James M. Cheverud, Gloria L. Fawcett, Joseph P. Jarvis, Elizabeth A. Norgard, Mihaela Pavlicev, L. Susan Pletscher, Kenneth S. Polonsky, Honggang Ye, Graeme I. Bell, Clay F. Semenkovich
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 907-913 (2010)
We previously mapped Adip1, an obesity quantitative trait locus (QTL), to the central portion of murine chromosome 1 containing the calpain-10 (Capn10) gene. Human studies have associated calpain-10 (CAPN10) variants with type 2 diabetes and various
Externí odkaz:
https://doaj.org/article/c79151826d384ca698b1bb5170264cac