Zobrazeno 1 - 3
of 3
pro vyhledávání: '"James M. Bougie"'
Autor:
Lewis C. Cantley, William Leister, Kyle R. Brimacombe, Matthew G. Vander Heiden, Henrike Veith, Martin J. Walsh, Matthew B. Boxer, Min Shen, Douglas S. Auld, James M. Bougie, Thomas Daniel, Craig J. Thomas, William J. Israelsen
Publikováno v:
PMC
Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform i
Autor:
Michael Holinstat, David A. Taylor-Fishwick, David J. Maloney, J. Brian Jameson, Jerry L. Nadler, William Leister, Michelle Armstrong, Ganesha Rai, Theodore R. Holman, Netra Joshi, James M. Bougie, Ajit Jadhav, Lena Schultz, Steve Perry, Anton Simeonov, Victor Kenyon
Publikováno v:
Journal of Medicinal Chemistry. 54:5485-5497
We report the discovery of novel small molecule inhibitors of platelet type 12-human lipoxygenase, which display nanomolar activity against the purified enzyme, using a quantitative high throughput screen (qHTS) on a library of 153,607 compounds. The
Autor:
Bryan T. Mott, Min Shen, Dac-Trung Nguyen, James M. Bougie, Cordelle Tanega, Andrew S. Rosenthal, David J. Maloney, Craig J. Thomas, Douglas S. Auld, Tom Misteli
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive