Zobrazeno 1 - 10
of 91
pro vyhledávání: '"James M. Binley"'
Autor:
Emma T. Crooks, Francisco Almanza, Alessio D’Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D. Allen, Alyssa Thomas, Keiko Osawa, Bette T. Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K. Verkoczy, James M. Binley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Externí odkaz:
https://doaj.org/article/30ea4c2a548142c8b204822f276498bc
Autor:
Tommy Tong, Alessio D'Addabbo, Jiamin Xu, Himanshi Chawla, Albert Nguyen, Paola Ochoa, Max Crispin, James M Binley
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011452 (2023)
Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41). These mutations have been leveraged for u
Externí odkaz:
https://doaj.org/article/da0b002c81154636a46ef072541aaecf
Publikováno v:
AIDS Res Hum Retroviruses
Human immunodeficiency virus type-1 (HIV-1) antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAbs). Over the last 10-15 years, great progress has been made to understand the conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316efb7108e0856457d72a083df08eaa
https://doi.org/10.1089/aid.2020.0299
https://doi.org/10.1089/aid.2020.0299
Autor:
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006148 (2017)
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially imp
Externí odkaz:
https://doaj.org/article/8a81c72949514c31829e9f7bf5c3f8b9
Autor:
Francisco Almanza, Jinsong Zhang, Yaroslav Tsybovsky, Erika Duggan, Max Crispin, Kshitij Wagh, John P. Nolan, Joel D. Allen, Keiko Osawa, James M. Binley, Huihui Mou, Alyssa Thomas, Alessio D'addabbo, Evan M. Cale, Emma T. Crooks, Laurent Verkoczy, Bette T. Korber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9dd6f08a8829eb621503bf848f4d3a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/?tool=EBI
Autor:
Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004932 (2015)
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits
Externí odkaz:
https://doaj.org/article/65b7f896418649c1899f642d72673ccb
Autor:
Ilja Bontjer, Mark Melchers, Tommy Tong, Thijs van Montfort, Dirk Eggink, David Montefiori, William C Olson, John P Moore, James M Binley, Ben Berkhout, Rogier W Sanders
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67484 (2013)
Despite almost 30 years of research, no effective vaccine has yet been developed against HIV-1. Probably such a vaccine would need to induce both an effective T cell and antibody response. Any vaccine component focused on inducing humoral immunity re
Externí odkaz:
https://doaj.org/article/fd047f5f3ef148a7952b4af0aa97b280
Autor:
James M. Binley, Tommy Tong, William R. Schief, Samantha L. Grimley, Robert G. Whalen, Yang D. Dai, Ema T. Crooks, Daniel W. Kulp, Keiko Osawa, Sergey Menis
Publikováno v:
Virology. 505:193-209
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18698d86850c909ab3b57f99cca64946
https://doi.org/10.1016/j.virol.2017.02.024
https://doi.org/10.1016/j.virol.2017.02.024
Autor:
Kristi Marquardt, Linda A. Sherman, M. Jubayer Rahman, James M. Binley, Wen-Yuan Hu, Yang D. Dai, Danielle Regn, Roman Bashratyan, Elizabeth Fink, John H. Elder
Publikováno v:
European Journal of Immunology. 47:575-584
Secreted microvesicles (MVs) are potent inflammatory triggers that stimulate autoreactive B and T cells, causing Type 1 Diabetes in non-obese diabetic (NOD) mice. Proteomic analysis of purified MVs released from islet cells detected the presence of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c2462a668627e0049f5a613145dcfb
https://doi.org/10.1002/eji.201646755
https://doi.org/10.1002/eji.201646755
Autor:
Guillaume Stewart-Jones, Mark A. Hallen, Hong Zhao, Bruce R. Donald, Lawrence Shapiro, James Arthos, Madhu Prabhakaran, Jonathan Stuckey, Peter D. Kwong, M. Gordon Joyce, Constance Williams, Gilad Ofek, James M. Binley, Emma T. Crooks, Sijy O'Dell, Adam Harned, Lawrence K. Lee, Young Do Kwon, Scott C. Blanchard, Tatsiana Kirys, Gwo-Yu Chuang, Susan Zolla-Pazner, Mallika Sastry, Daniel S. Terry, Ulrich Baxa, Yongping Yang, Paul V. Thomas, Arne Schön, Cinque Soto, Xiaochu Ma, Sandeep Narpala, James B. Munro, Michael Chambers, Ernesto Freire, Keiko Osawa, Nicole A. Doria-Rose, Kelly K. Lee, Tishina Tittley, Priyamvada Acharya, Miklos Guttman, Aliaksandr Druz, Tongqing Zhou, Zhou Zhou, Ivelin S. Georgiev, Walther Mothes, Baoshan Zhang, Goran Ahlsen, Adrian B. McDermott, Marie Pancera, Mark K. Louder, Jason Gorman, Robert T. Bailer, John R. Mascola
Publikováno v:
Nature structural & molecular biology
As the sole viral antigen on the HIV-1-virion surface, trimeric Env is a focus of vaccine efforts. Here we present the structure of the ligand-free HIV-1-Env trimer, fix its conformation, and determine its receptor interactions. Epitope analyses reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c87910e7f823705fd301716d9124c79
http://europepmc.org/articles/PMC4706170
http://europepmc.org/articles/PMC4706170