Zobrazeno 1 - 10
of 120
pro vyhledávání: '"James M. Binley"'
Autor:
Tommy Tong, Alessio D'Addabbo, Jiamin Xu, Himanshi Chawla, Albert Nguyen, Paola Ochoa, Max Crispin, James M Binley
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011452 (2023)
Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41). These mutations have been leveraged for u
Externí odkaz:
https://doaj.org/article/da0b002c81154636a46ef072541aaecf
Autor:
Emma T. Crooks, Francisco Almanza, Alessio D’Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D. Allen, Alyssa Thomas, Keiko Osawa, Bette T. Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K. Verkoczy, James M. Binley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Externí odkaz:
https://doaj.org/article/30ea4c2a548142c8b204822f276498bc
Publikováno v:
AIDS Res Hum Retroviruses
Human immunodeficiency virus type-1 (HIV-1) antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAbs). Over the last 10-15 years, great progress has been made to understand the conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316efb7108e0856457d72a083df08eaa
https://doi.org/10.1089/aid.2020.0299
https://doi.org/10.1089/aid.2020.0299
Autor:
Ema T Crooks, Samantha L Grimley, Michelle Cully, Keiko Osawa, Gillian Dekkers, Kevin Saunders, Sebastian Rämisch, Sergey Menis, William R Schief, Nicole Doria-Rose, Barton Haynes, Ben Murrell, Evan Mitchel Cale, Amarendra Pegu, John R Mascola, Gestur Vidarsson, James M Binley
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007024 (2018)
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with othe
Externí odkaz:
https://doaj.org/article/07efec52348049c5a19cfd97bdec12dd
Autor:
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006148 (2017)
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially imp
Externí odkaz:
https://doaj.org/article/8a81c72949514c31829e9f7bf5c3f8b9
Autor:
Francisco Almanza, Jinsong Zhang, Yaroslav Tsybovsky, Erika Duggan, Max Crispin, Kshitij Wagh, John P. Nolan, Joel D. Allen, Keiko Osawa, James M. Binley, Huihui Mou, Alyssa Thomas, Alessio D'addabbo, Evan M. Cale, Emma T. Crooks, Laurent Verkoczy, Bette T. Korber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9dd6f08a8829eb621503bf848f4d3a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/?tool=EBI
Autor:
Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004932 (2015)
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits
Externí odkaz:
https://doaj.org/article/65b7f896418649c1899f642d72673ccb
Autor:
Johannes S Gach, Heribert Quendler, Tommy Tong, Kristin M Narayan, Sean X Du, Robert G Whalen, James M Binley, Donald N Forthal, Pascal Poignard, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72054 (2013)
Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally pot
Externí odkaz:
https://doaj.org/article/cce40e1dc2ad4d5893581ac52a615e3f
Autor:
Ilja Bontjer, Mark Melchers, Tommy Tong, Thijs van Montfort, Dirk Eggink, David Montefiori, William C Olson, John P Moore, James M Binley, Ben Berkhout, Rogier W Sanders
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67484 (2013)
Despite almost 30 years of research, no effective vaccine has yet been developed against HIV-1. Probably such a vaccine would need to induce both an effective T cell and antibody response. Any vaccine component focused on inducing humoral immunity re
Externí odkaz:
https://doaj.org/article/fd047f5f3ef148a7952b4af0aa97b280
Autor:
James M. Binley, Tommy Tong, William R. Schief, Samantha L. Grimley, Robert G. Whalen, Yang D. Dai, Ema T. Crooks, Daniel W. Kulp, Keiko Osawa, Sergey Menis
Publikováno v:
Virology. 505:193-209
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18698d86850c909ab3b57f99cca64946
https://doi.org/10.1016/j.virol.2017.02.024
https://doi.org/10.1016/j.virol.2017.02.024