Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James M. Bean"'
Autor:
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich, Dirk Schnappinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that rv1590, a gene
Externí odkaz:
https://doaj.org/article/3054e679f3564df091570ea68d735626
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Autor:
Qianjing Xia, Myung Hee Lee, Kathleen F. Walsh, Kathrine McAulay, James M. Bean, Daniel W. Fitzgerald, Kathryn M. Dupnik, Warren D. Johnson, Jean W. Pape, Kyu Y. Rhee, Flonza Isa
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
BACKGROUND Control of the tuberculosis (TB) pandemic remains hindered in part by a lack of simple and accurate measures of treatment efficacy, as current gold standard markers rely on sputum-based assays that are slow and challenging to implement. Ho
Externí odkaz:
https://doaj.org/article/1f353370c9574fc693fd6c3d98cdf813
Autor:
Flonza Isa, Sean Collins, Myung Hee Lee, Diessy Decome, Nancy Dorvil, Patrice Joseph, Lauren Smith, Stephen Salerno, Martin T. Wells, Steven Fischer, James M. Bean, Jean W. Pape, Warren D. Johnson, Daniel W. Fitzgerald, Kyu Y. Rhee
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 157-165 (2018)
Background: Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for d
Externí odkaz:
https://doaj.org/article/a909d743f2ed405095d4198d0791fee4
Autor:
Matthew F. Wipperman, Daniel W. Fitzgerald, Marc Antoine Jean Juste, Ying Taur, Sivaranjani Namasivayam, Alan Sher, James M. Bean, Vanni Bucci, Michael S. Glickman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mix
Externí odkaz:
https://doaj.org/article/f66b6683dbd843a1b6958015744bf3a6
Publikováno v:
Nucleic Acids Research
DNA repair systems allow microbes to survive in diverse environments that compromise chromosomal integrity. Pathogens such as Mycobacterium tuberculosis must contend with the genotoxic host environment, which generates the mutations that underlie ant
Autor:
Shipra Grover, Curtis A. Engelhart, Esther Perez‐Herran, Divya Tiwari, Wei Li, Katherine A. Abrahams, Kadamba Papavinasasundaram, James M. Bean, Christopher M. Sassetti, Alfonso Mendoza‐Losana, Gurdyal S. Besra, Mary Jackson, Courtney Aldrich, Dirk Schnappinger
Publikováno v:
The FASEB Journal. 36
Autor:
Shipra, Grover, Curtis A, Engelhart, Esther, Pérez-Herrán, Wei, Li, Katherine A, Abrahams, Kadamba, Papavinasasundaram, James M, Bean, Christopher M, Sassetti, Alfonso, Mendoza-Losana, Gurdyal S, Besra, Mary, Jackson, Dirk, Schnappinger
Publikováno v:
ACS Infectious Diseases
MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targe
Publikováno v:
eLife
Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For Mycobacterium tuberculosis, the causative agent of tuberculosis, these mechanisms allow the bacterium to rapidly adapt
Autor:
James M. Bean, Alan Sher, Ying Taur, Michael S. Glickman, Marc Antoine Jean Juste, Sivaranjani Namasivayam, Matthew F. Wipperman, Daniel W. Fitzgerald, Vanni Bucci
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of b