Zobrazeno 1 - 10
of 70
pro vyhledávání: '"James M. Balkovec"'
Autor:
Caroline N. Jones, Felix Ellett, Anne L. Robertson, Kevin M. Forrest, Kevin Judice, James M. Balkovec, Martin Springer, James F. Markmann, Jatin M. Vyas, H. Shaw Warren, Daniel Irimia
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients. Neutrophils play a critical role in control of infection but may be diminished in number and function during immunosuppressive therapies. Here, we me
Externí odkaz:
https://doaj.org/article/47e6e17753be439a8ce215b1c7cd487e
Autor:
David G. McLaren, Timothy He, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, Karen Gagen, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sloan Stribling, Andrew Taggart, Jason Imbriglio, Jinqi Liu, Dunlu Chen, Shirly Pinto, James M. Balkovec, Robert J. DeVita, Donald J. Marsh, Jose M. Castro-Perez, Alison Strack, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1150-1161 (2011)
The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to be gained from such studies is of partic
Externí odkaz:
https://doaj.org/article/d66b12300bbf4a1f976747589c656716
Autor:
Yanan Zhao, Grayson Hough, Alain Noncovich, Allen J. Borchardt, Qiping Zhao, Joanne Fortier, James M. Balkovec, Jason N. Cole, Brady Thomas P, Quyen Quyen Do, David S. Perlin, Mila Krel, Jiang Wanlong, Les Tari, Arianne Lovey
Publikováno v:
Antimicrob Agents Chemother
The widespread emergence of antibiotic resistance, including multidrug resistance in Gram-negative (G-) bacterial pathogens, poses a critical challenge to the current antimicrobial armamentarium. Antibody-drug conjugates (ADCs), primarily used in ant
Autor:
Dong-Ming Shen, Michael Wolff, Shirly Pinto, Deodial Guiadeen, Bindhu V. Karanam, James M. Balkovec, Arto D. Krikorian, Shuwen He, Maria Madeira, Donald M. Sperbeck, Andreas Verras, Judyann Wiltsie, Jian Liu, Jackie Shang, Tim Cernak, Beth Ann Murphy, Qingmei Hong, Christine C. Chung, Ravi P. Nargund, Kevin D. Dykstra, Judith N. Gorski, Robert J. DeVita, Sharon Tong, Tianying Jian, Lisa M. Sonatore, Jeffrey T. Kuethe, Jianying Xiao, Jinqi Liu, Zhong Lai, Zhicai Wu, Mikhail Reibarkh, Ginger X. Yang, Yang Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1182-1186
Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition compa
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Autor:
Nicholas Dedeic, Amanda L. Almaguer, Joanne Fortier, Jason N. Cole, Brady Thomas P, Grayson Hough, Thanh Lam, Karin Amundson, James M. Balkovec, Allen J. Borchardt, Jeffrey B. Locke, Simon Döhrmann, Les Tari, Rajvir Grewal, Ken Bartizal, Voon Ong, Mike Schlosser, Elizabeth Abelovski, James Levin, Alain Noncovich
Publikováno v:
Open Forum Infectious Diseases
Background CD377 is a novel antiviral Fc-conjugate (AVC) development candidate for influenza prevention and treatment, comprising multiple copies of a novel potent small-molecule antiviral and the Fc domain of human IgG1. CD377 was designed as a stab
Autor:
B. Radha Krishnan, Kenneth D. James, Grayson Hough, James M. Balkovec, Ken Bartizal, Voon Ong, Michael J. Schlosser
Publikováno v:
Antimicrobial Agents and Chemotherapy
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evalua
Autor:
Robert J. De Vita, Zhi-Cai Shi, Bindhu V. Karanam, Beth Ann Murphy, Shuwen He, Tianying Jian, Christine C. Chung, Maria Madeira, Qingmei Hong, Tim Cernak, Ravi P. Nargund, James M. Balkovec, Donald M. Sperbeck, Min Liu, Andreas Verras, Judyann Wiltsie, Jian Liu, Lisa M. Sonatore, Sharon Tong, Shirly Pinto, Deodial Guiadeen, Michael Wolff, Zhicai Wu, Dong-Ming Shen, Arto D. Krikorian, Yang Yu, Judith N. Gorski, Petr Vachal, Jianying Xiao, Jinqi Liu, Zhong Lai
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(11)
The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1) inhibitors. Through a highly collaborative and iterative library design, synthesis and testing, a benzimidazo
Autor:
James M. Balkovec
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a8b5da8d730c0239d7c5dbd0340b7a0
https://doi.org/10.29200/acsmedchemrev-v53.ch16
https://doi.org/10.29200/acsmedchemrev-v53.ch16
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe