Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James M. Apgar"'
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a5b1dc4caa4f8e8040bb53f3f65ed
https://pubmed.ncbi.nlm.nih.gov/33160023
https://pubmed.ncbi.nlm.nih.gov/33160023
Autor:
Hong-Ping Guan, Wen Feng, Daniel M. Kemp, Judith N. Gorski, Shiyao Xu, Ying Li, Dan Zhou, Ku Lu, Tesfaye Biftu, David E. Kelley, Chuanlin Wang, Sandra C. Souza, Lan Wei, Danqing Feng, Robert R. Wilkening, Andrea R. Nawrocki, Iyassu K. Sebhat, Mark J. Rosenbach, Margaret van Heek, Carlos G. Rodriguez, Eric S. Muise, Xiaodong Yang, Mark D. Erion, Jinqi Liu, Stephen F. Previs, James M. Apgar, Marc M. Kurtz, Huaibing He, Robert W. Myers, Xiaolan Shen, Kenneth J. Leavitt
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
PLoS ONE
PLoS ONE
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e74f669b91225dbd7a81a386f22662b
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f12625a2e82e86dbbc4c61aa3a8424
https://doi.org/10.1016/j.bmcl.2015.10.011
https://doi.org/10.1016/j.bmcl.2015.10.011
Autor:
Dann L. Parker, James M. Apgar, Robert A. Giacobbe, Ming Jo Hsu, Kingsley H. Nelson, Gregory J. Pacofsky, Paul A. Liberator, Fred Racine, Dongfang Meng, Ghjuvanni Coti, James M. Balkovec, Ahmed Mamai, Brian H. Heasley, Mark L. Greenlee, Jennifer Nielsen Kahn, Michael Robert Peel, Robert R. Wilkening, Hao Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6811-6816
Orally bioavailable inhibitors of β-(1,3)- d -glucan synthase have been pursued as new, broad-spectrum fungicidal therapies suitable for treatment in immunocompromised patients. Toward this end, a collaborative medicinal chemistry program was establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0eb37f90354231988b66512b32d5ce
https://doi.org/10.1016/j.bmcl.2012.05.031
https://doi.org/10.1016/j.bmcl.2012.05.031
Autor:
Joseph K. Wu, George J. Eiermann, Jeffrey T. Kuethe, Robert R. Wilkening, Aleksandr Petrov, Xiaohua Li, Ann E. Weber, Jason M. Cox, Ping Chen, Tesfaye Biftu, Kathryn A. Lyons, Joseph M. Metzger, Dennis Feng, Huaibing He, Ying-Duo Gao, Youwei Yan, James M. Apgar, Shiyao Xu, Ranabir Sinha Roy, Giovanna Scapin, Xiaoxia Qian, George A. Doss
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(24)
A series of novel substituted-[(3R)-amino-2-(2,5-difluorophenyl)]tetrahydro-2H-pyran analogs have been prepared and evaluated as potent, selective and orally active DPP-4 inhibitors. These efforts lead to the discovery of a long acting DPP-4 inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3841d78bae66cfd858b20702956053a6
https://pubmed.ncbi.nlm.nih.gov/26546218
https://pubmed.ncbi.nlm.nih.gov/26546218
Autor:
Gabor Lazar, Philip A. Lessard, Derek Sturtevant, Binzhang Shen, R. Michael Raab, Mary L. Ross, Sarah Dohle, James M. Apgar, Xiao Zuo, Humberto de la Vega
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37355 (2012)
PLoS ONE
PLoS ONE
Inteins are intervening protein domains with self-splicing ability that can be used as molecular switches to control activity of their host protein. Successfully engineering an intein into a host protein requires identifying an insertion site that pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d4ceca0b734ef26a5cf0843be40e8b
https://doi.org/10.1371/journal.pone.0037355
https://doi.org/10.1371/journal.pone.0037355
Autor:
Muise, Eric S.1 eric_muise@merck.com, Guan, Hong-Ping2, Liu, Jinqi2, Nawrocki, Andrea R.3, Yang, Xiaodong2, Wang, Chuanlin2, Rodríguez, Carlos G.3, Zhou, Dan3, Gorski, Judith N.3, Kurtz, Marc M.4, Feng, Danqing5, Leavitt, Kenneth J.5, Wei, Lan5, Wilkening, Robert R.5, Apgar, James M.5, Xu, Shiyao6, Lu, Ku2, Feng, Wen2, Li, Ying2, He, Huaibing6
Publikováno v:
PLoS ONE. 2/27/2019, Vol. 14 Issue 2, p1-29. 29p.
Autor:
Brishty, Shejuti Rahman, Hossain, Md. Jamal, Khandaker, Mayeen Uddin, Faruque, Mohammad Rashed Iqbal, Osman, Hamid, Rahman, S. M. Abdur
Publikováno v:
Frontiers in Pharmacology; 11/3/2021, Vol. 12, p1-49, 49p