Zobrazeno 1 - 10
of 66
pro vyhledávání: '"James M. Angelastro"'
Publikováno v:
Cells, Vol 12, Iss 4, p 581 (2023)
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine z
Externí odkaz:
https://doaj.org/article/fcdf20cdec87409184f41d4d3ae31c48
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 111058- (2021)
Glioblastoma Multiforme (GBM) tumors contain a small population of glioma stem-like cells (GSCs) among the various differentiated GBM cells (d-GCs). GSCs drive tumor recurrence, and resistance to Temozolomide (TMZ), the standard of care (SoC) for GBM
Externí odkaz:
https://doaj.org/article/5b0e2957d5b54eeea2bcfdef61e19774
Autor:
Qing Zhou, Xiotian Sun, Nicolas Pasquier, Parvaneh Jefferson, Trang T. T. Nguyen, Markus D. Siegelin, James M. Angelastro, Lloyd A. Greene
Publikováno v:
Cancers, Vol 13, Iss 10, p 2504 (2021)
Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synth
Externí odkaz:
https://doaj.org/article/0b7b0db371af4876aacd2b9605536c8a
Autor:
Jose A. Sandoval, Alexey Tomilov, Sandipan Datta, Sonia Allen, Robert O’Donnell, Thomas Sears, Kevin Woolard, Dmytro Kovalskyy, James M. Angelastro, Gino Cortopassi
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 419 (2020)
Glioblastoma (GBM) is an aggressive tumor of the brain, with an average post-diagnosis survival of 15 months. GBM stem cells (GBMSC) resist the standard-of-care therapy, temozolomide, and are considered a major contributor to tumor resistance. Mammal
Externí odkaz:
https://doaj.org/article/3295d22d855242e496e1639f9d64a2a7
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 1, Pp 54-74 (2005)
We employed Serial Analysis of Gene Expression to identify transcriptional changes in a cellular model of Parkinson Disease (PD). The model consisted of neuronally differentiated PC12 cells compared before and after 8 hours' exposure to 6-hydroxydopa
Externí odkaz:
https://doaj.org/article/ea4c10529b744921ac4dc63fa092329b
Recent reports indicate that the activating transcription factor 5 (ATF5) is required for the survival of cancer cells but not for noncancer cells. However, the mechanisms by which ATF5 regulates genes and promotes cell survival are not clear. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679376a7f39e4f48c8fba899419f06b
https://doi.org/10.1158/1541-7786.c.6542056.v1
https://doi.org/10.1158/1541-7786.c.6542056.v1
Supplementary Data from Identification of a Novel DNA Binding Site and a Transcriptional Target for Activating Transcription Factor 5 in C6 Glioma and MCF-7 Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8572e84dc160f1f04f151919abd4f6ed
https://doi.org/10.1158/1541-7786.22518661
https://doi.org/10.1158/1541-7786.22518661
Autor:
Markus D. Siegelin, James M. Angelastro, Lloyd A. Greene, Peter Canoll, Jeffrey N. Bruce, Takashi Tsujiuchi, Lily Chau, Chang Shu, Basil A. Horst, Georg Karpel-Massler
Suppl. fig. 1: Effect of CP-d/n-ATF5-S1 on ATF5 expression and stability Suppl. fig. 2: Effect of CP-d/n-ATF5-S1 on ASNS mRNA expression Suppl. fig. 3: Effect of CP-d/n-ATF5-S1 on cell viability in HL-60 cells Suppl. fig. 4: Pro-apoptotic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002a4e15a2bd6b46719276556fefbdfb
https://doi.org/10.1158/1078-0432.22462026
https://doi.org/10.1158/1078-0432.22462026
Autor:
Markus D. Siegelin, James M. Angelastro, Lloyd A. Greene, Peter Canoll, Jeffrey N. Bruce, Takashi Tsujiuchi, Lily Chau, Chang Shu, Basil A. Horst, Georg Karpel-Massler
Supplementary figure legend unmarked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5773987febf16a337f41ed8f7aa0a63
https://doi.org/10.1158/1078-0432.22462029
https://doi.org/10.1158/1078-0432.22462029
Autor:
Markus D. Siegelin, James M. Angelastro, Lloyd A. Greene, Peter Canoll, Jeffrey N. Bruce, Takashi Tsujiuchi, Lily Chau, Chang Shu, Basil A. Horst, Georg Karpel-Massler
Supplementary materials and methods untracked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0854116c8e26a2d241244da30f63940d
https://doi.org/10.1158/1078-0432.22462023
https://doi.org/10.1158/1078-0432.22462023