We predict a riot: inequity, relative deprivation and collective destruction in the laboratory

Autor: Jorina von Zimmermann, James M. Allen, Guillaume Dezecache, Daniel C. Richardson

Publikováno v: Proceedings of the Royal Society B: Biological Sciences
Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2021, 288 (1959), pp.20203091. ⟨10.1098/rspb.2020.3091⟩
Proc Biol Sci
Proceedings of the Royal Society B: Biological Sciences, 2021, 288 (1959), pp.20203091. ⟨10.1098/rspb.2020.3091⟩

Riots are unpredictable and dangerous. Our understanding of the factors that cause riots is based on correlational observations of population data, or post hoc introspection of individuals. To complement these accounts, we developed innovative experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18128b84cff8af63609d54051b2dd5
https://hal.archives-ouvertes.fr/hal-03351410

The polyproline site in hinge 2 influences the functional capacity of truncated dystrophins.

Autor: Glen B Banks, Luke M Judge, James M Allen, Jeffrey S Chamberlain

Publikováno v: PLoS Genetics, Vol 6, Iss 5, p e1000958 (2010)

Mutations in dystrophin can lead to Duchenne muscular dystrophy or the more mild form of the disease, Becker muscular dystrophy. The hinge 3 region in the rod domain of dystrophin is particularly prone to deletion mutations. In-frame deletions of hin

Externí odkaz: https://doaj.org/article/52c54bef1909468bbeff6202b75c0e22

AAV6 Vector Production and Purification for Muscle Gene Therapy

Autor: James M. Allen, Jeffrey S. Chamberlain, Christine L. Halbert

Publikováno v: Methods in Molecular Biology ISBN: 9781493973736

Vectors derived from adeno-associated viruses (AAV) have been generated using numerous naturally occurring and synthetic serotypes of the virus. Such vectors have proven to be extremely useful for a variety of gene transfer studies, both in vitro and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d27e824b6908a89d8f76276bb11c2a
https://doi.org/10.1007/978-1-4939-7374-3_18

Heparin-binding correlates with increased efficiency of AAV1- and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction

Autor: James M. Allen, Richard D. Palmiter, Jeffrey S. Chamberlain, Andrea L. Arnett, Albert Quintana, Lisa R. Beutler, Eric E. Finn

Publikováno v: Gene Therapy. 20:497-503

Gene delivery vectors derived from adeno-associated virus (AAV) have great potential as therapeutic agents. rAAV1 and rAAV6, efficiently target striated muscle, but the mechanisms that determine their tropism remain unclear. It is known that AAV6, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77a821adaf386a07579eb6867654b2e
https://doi.org/10.1038/gt.2012.60

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Autor: Mark A. Febbraio, Claudia Beyer, Jeffrey S. Chamberlain, Catherine E. Winbanks, Julie R. McMullen, James M. Allen, Hongwei Qian, Patricio V. Sepulveda, Justin L. Chen, Graeme I. Lancaster, Kate L. Weeks, Rachel E. Thomson, Paul Gregorevic, Craig A. Harrison

Publikováno v: The Journal of Cell Biology

Smad3/Akt/mTOR/S6K/S6RP signaling plays a critical role in follistatin-mediated muscle growth that operates independently of myostatin-driven mechanisms.
Follistatin is essential for skeletal muscle development and growth, but the intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b447ce78fd65c4c14c4c30fa1b8ef6
https://doi.org/10.1083/jcb.201109091