Zobrazeno 1 - 10
of 40
pro vyhledávání: '"James M Stafford"'
Autor:
Matthew P McCabe, Erin R Cullen, Caitlynn M Barrows, Amy N Shore, Katherine I Tooke, Kathryn A Laprade, James M Stafford, Matthew C Weston
Publikováno v:
eLife, Vol 9 (2020)
Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major mechanism through which altered mTOR signaling leads to neurological disease. Althou
Externí odkaz:
https://doaj.org/article/3c48f14c2ef0425787d145d466e11f86
Autor:
Xin Rui Lim, Mohammad M. Abd-Alhaseeb, Michael Ippolito, Masayo Koide, Amanda J. Senatore, Curtis Plante, Ashwini Hariharan, Nick Weir, Thomas A. Longden, Kathryn A. Laprade, James M. Stafford, Dorothea Ziemens, Markus Schwaninger, Jan Wenzel, Dmitry D. Postnov, Osama F. Harraz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Hyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O2 and nutrients, clears metabolic waste, and concomitantly exposes cerebrovascular endothelial cells to hemodynamic forces. While neurovas
Externí odkaz:
https://doaj.org/article/e1f0cdd225cb4b8b8a10b16f5e16f028
Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review
Autor:
Matthew Gallitto, BA, Stanislav Lazarev, MD, Isaac Wasserman, MPH, James M. Stafford, PhD, Suzanne L. Wolden, MD, Stephanie A. Terezakis, MD, Ranjit S. Bindra, MD, PhD, Richard L. Bakst, MD
Publikováno v:
Advances in Radiation Oncology, Vol 4, Iss 3, Pp 520-531 (2019)
Purpose: Diffuse intrinsic pontine glioma (DIPG) is the most aggressive primary pediatric brain tumor, with
Externí odkaz:
https://doaj.org/article/7582db0aa2df46228a2bd141a25069e2
Autor:
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L. Stapleton, David Zagzag, Luis Chiriboga, Sharon L. Gardner, Jeffrey H. Wisoff, John G. Golfinos, David Capper, Volker Hovestadt, Marc K. Rosenblum, Dimitris G. Placantonakis, Sarah E. LeBoeuf, Thales Y. Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G. Eberhart, Stefan M. Pfister, David T. W. Jones, Matthias A. Karajannis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Pineoblastoma is a highly aggressive and rare childhood brain cancer, and the genetic drivers of sporadic pineoblastoma are unknown. Here, the authors genomically interrogated pediatric and adult pineoblastomas and found novel variants including recu
Externí odkaz:
https://doaj.org/article/ead93584496f48eaacd71d7cac4d1501
Autor:
Aram S. Modrek, Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, Guoan Zhang, Pedro P. Rocha, Ramya Raviram, Charalampos Lazaris, James M. Stafford, Gary LeRoy, Michael Kader, Joravar Dhaliwal, N. Sumru Bayin, Joshua D. Frenster, Jonathan Serrano, Luis Chiriboga, Rabaa Baitalmal, Gouri Nanjangud, Andrew S. Chi, John G. Golfinos, Jing Wang, Matthias A. Karajannis, Richard A. Bonneau, Danny Reinberg, Aristotelis Tsirigos, David Zagzag, Matija Snuderl, Jane A. Skok, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1267-1280 (2017)
Summary: Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs).
Externí odkaz:
https://doaj.org/article/6c38719ab387499d9cbeaef12ccef89b
Autor:
Luis Chiriboga, Matija Snuderl, Valerio Conti, Briana Zeck, Javier Hernaez Rodriguez, Adriana Heguy, Maristela L. Onozato, Claudio Forcato, Anna Maria Buccoliero, Hussein Mohamed, Sitharam Ramaswami, Marianna Garonzi, Kaicen Zhu, Jonathan Serrano, Jane A. Skok, Varshini Vasudevaraja, Eveline Teresa Hidalgo, Daniel Friedman, Aristotelis Tsirigos, Arline Faustin, A. John Iafrate, David Zagzag, Renzo Guerrini, Cristiana Pelorosso, James M. Stafford, Orrin Devinsky, Lily M. Tredwin, John G. Golfinos
Publikováno v:
J Neuropathol Exp Neurol
Epilepsy is a heterogenous group of disorders defined by recurrent seizure activity due to abnormal synchronized activity of neurons. A growing number of epilepsy cases are believed to be caused by genetic factors and copy number variants (CNV) contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f87999001f614d1fe8b7f7b94fa1725
https://doi.org/10.1093/jnen/nlaa137
https://doi.org/10.1093/jnen/nlaa137
Autor:
Ryan P. Hobbs, Zhuangzhuang Geng, Yinsheng Wang, Trevor Wolf, Jessenia Chavez, Weili Miao, James M. Stafford, Emily Giddings, Qiang Wang, Zhonghua Gao, David J. DeGraff
SummaryDespite a prominent risk factor for Neurodevelopmental disorders (NDD), it remains unclear how Autism Susceptibility Candidate 2 (AUTS2) controls the neurodevelopmental program. Our studies investigated the role of AUTS2 in neuronal differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b4786dba6e76f03159d4c7b4b90f6f1
https://doi.org/10.1101/2021.06.29.450402
https://doi.org/10.1101/2021.06.29.450402
Autor:
Benjamin A. Garcia, Chul Hwan Lee, Gary LeRoy, Jeffrey Granat, Jia Ray Yu, Ricardo Saldaña-Meyer, Beatrix Ueberheide, Danny Reinberg, Peder J. Lund, Ying Jin, James M. Stafford, Joshua Andrade
Publikováno v:
Genes & Development. 33:1428-1440
The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been shown to automethylate its core subunits, EZH1/EZH2 and SUZ12. Here, we identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e625f2f6c034e807da3f628fab790d
https://doi.org/10.1101/gad.328773.119
https://doi.org/10.1101/gad.328773.119
Autor:
Andrew Swale, Nicolas Descostes, William B. Dobyns, Sanxiong Liu, Christiane Zweier, Chai-An Mao, Ivan Ivanovski, Danny Reinberg, Livia Garavelli, Megan T. Cho, James M. Stafford, Wukui Zhao, Tudor C. Badea, Pedro Lee, Kimberly A. Aldinger, Orsetta Zuffardi, Takae Kiyama, Jennifer B. Humberson, M. Scott Perry, Astrid Weber, Edoardo Errichiello, Stefano Giuseppe Caraffi, Hanna K. McNamara, Michael C. Schneider, Antigone Papavasiliou, Chi Vicky Cheng, Mitali Dave
Publikováno v:
Mol Cell
SUMMARYThe heterogeneous complexes comprising the family of Polycomb Repressive Complex 1 (PRC1) are instrumental to establishing facultative heterochromatin that is repressive to transcription. Yet, two PRC1 species, PRC1.3 and PRC1.5, are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6d4d7c7ce813bbeb631b6c7eaa9ea5
https://doi.org/10.1101/2021.03.30.437620
https://doi.org/10.1101/2021.03.30.437620
Publikováno v:
Neuro-Oncology
Diffuse intrinsic pontine glioma (DIPG) is a group of predominantly pediatric brain tumors with an average age of diagnosis of 6–7 years old, and a poor prognosis (median survival of ~1 year). Given the location of DIPG in the brainstem, surgical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67775223e1a9aeab03364e7ab10d34e3
https://doi.org/10.1093/neuonc/noab090.100
https://doi.org/10.1093/neuonc/noab090.100