Zobrazeno 1 - 10
of 153
pro vyhledávání: '"James M Piret"'
Autor:
Diepiriye G. Iworima, Robert K. Baker, Cara Ellis, Chris Sherwood, Lisa Zhan, Alireza Rezania, James M. Piret, Timothy J. Kieffer
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Background Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet transplantation can help regulate their blood glucose levels. H
Externí odkaz:
https://doaj.org/article/eef5378a3b1e42df99f87e9d84023768
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33999 (2012)
The proliferation of pancreatic duct-like CK19+ cells has implications for multiple disease states including pancreatic cancer and diabetes mellitus. The in vitro study of this important cell type has been hampered by their limited expansion compared
Externí odkaz:
https://doaj.org/article/44412a2f00514333bb7c6b346430df83
Autor:
Jessica A Hill, Marta Szabat, Corinne A Hoesli, Blair K Gage, Yu Hsuan C Yang, David E Williams, Michael J Riedel, Dan S Luciani, Tatyana B Kalynyak, Kevin Tsai, Ziliang Ao, Raymond J Andersen, Garth L Warnock, James M Piret, Timothy J Kieffer, James D Johnson
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cell
Externí odkaz:
https://doaj.org/article/4597d03eed1c4485a31e9ca5441e029a
Autor:
Clive H Glover, Michael Marin, Connie J Eaves, Cheryl D Helgason, James M Piret, Jennifer Bryan
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 11, p e158 (2006)
Stem cell differentiation involves critical changes in gene expression. Identification of these should provide endpoints useful for optimizing stem cell propagation as well as potential clues about mechanisms governing stem cell maintenance. Here we
Externí odkaz:
https://doaj.org/article/245addf23271452a8c2d7e293a777a5f
Autor:
Mitchell J. S. Braam, Jia Zhao, Shenghui Liang, Shogo Ida, Nick K. Kloostra, Diepiriye G. Iworima, Mei Tang, Robert K. Baker, Nina Quiskamp, James M. Piret, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The generation of functional β-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is being investigated by many groups. We have developed a protocol to harvest and aggregate hPSC-de
Externí odkaz:
https://doaj.org/article/fad7c7701c714b55ac516ffdf75998a9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Human pluripotent stem cells (hPSCs) provide many opportunities for application in regenerative medicine due to their ability to differentiate into cells from all three germ layers, proliferate indefinitely, and replace damaged or dysfu
Externí odkaz:
https://doaj.org/article/ea6232bfd13f4492920ebb3a18c3c90b
Autor:
Shivani Gupta, Bhavana Shah, Coral Shek Fung, Pik Kay Chan, Devin L. Wakefield, Scott Kuhns, Chetan T. Goudar, James M. Piret
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Since 2015 more than 34 biosimilars have been approved by the FDA. This new era of biosimilar competition has stimulated renewed technology development focused on therapeutic protein or biologic manufacturing. One challenge in biosimilar development
Externí odkaz:
https://doaj.org/article/f597ecef324b422f993ca46d280d28f9
Publikováno v:
Acta Astronautica. 201:420-430
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb2e373d3987484e75286207b1f1b0b
https://doi.org/10.1016/j.actaastro.2022.09.019
https://doi.org/10.1016/j.actaastro.2022.09.019
Autor:
Katherine N. MacDonald, Michael G. Hall, Sabine Ivison, Sanjiv Gandhi, Ramon I. Klein Geltink, James M. Piret, Megan K. Levings
Publikováno v:
Cytotherapy. 24:1121-1135
Given the promising results from phase 1/2 clinical trials of therapy involving regulatory T cells (Tregs), it is critical to develop Treg manufacturing methods that use well-defined reagents.Seeking to maximize expansion of human thymic Tregs activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc022e2da3deb7a12b18f9b4c034ee2
https://doi.org/10.1016/j.jcyt.2022.06.006
https://doi.org/10.1016/j.jcyt.2022.06.006
Autor:
Marie-Soleil R Smith, Haneesha Mohan, Abhinav Ajaykumar, Anthony Y Y Hsieh, Lou Martineau, Ronil Patel, Izabella Gadawska, Christopher Sherwood, Lena Serghides, James M Piret, Hélène C F Côté
Publikováno v:
J Infect Dis
Background Each year, approximately 1.1 million children are exposed in utero to human immunodeficiency virus antiretrovirals, yet their safety is often not well characterized during pregnancy. The Tsepamo study reported a neural tube defect signal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76017f204e4f83ef3047c6304ac145b0
https://doi.org/10.1093/infdis/jiac386
https://doi.org/10.1093/infdis/jiac386