Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James M Pemberton"'
Autor:
James M Pemberton, Dang Nguyen, Elizabeth J Osterlund, Wiebke Schormann, Justin P Pogmore, Nehad Hirmiz, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 12 (2023)
Anti-apoptotic proteins such as BCL-XL promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins,
Externí odkaz:
https://doaj.org/article/c46858294f8f416e96855c98bce4cf03
Autor:
Philipp Mergenthaler, Santosh Hariharan, James M Pemberton, Corey Lourenco, Linda Z Penn, David W Andrews
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008630 (2021)
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-
Externí odkaz:
https://doaj.org/article/7cf9a9f1db0c4ccd8dbc99d773e496ea
Autor:
Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 9 (2020)
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the m
Externí odkaz:
https://doaj.org/article/3930186c3fd04ad4a33907088e2464c2
Fluorescence lifetime imaging microscopy (FLIM) can detect Fӧrster resonance energy transfer (FRET) to measure protein-protein interactions in live cells. Traditional FLIM-FRET uses relative intensities to represent protein expression, consequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3882eb55242b985bb0f537024ad6625c
https://doi.org/10.21203/rs.3.pex-1354/v1
https://doi.org/10.21203/rs.3.pex-1354/v1
Autor:
Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarède, Qian Liu, Brian Leber, Qiyin Fang, David W. Andrews
Publikováno v:
Science Advances. 8
Cytoplasmic and membrane-bound BCL-2 family proteins regulate apoptosis, a form of programmed cell death, via dozens of binary protein interactions confounding measurement of the effects of inhibitors in live cells. In cancer, apoptosis is frequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7693edb79c1d1712aef49cd51ea6871a
https://doi.org/10.1126/sciadv.abm7375
https://doi.org/10.1126/sciadv.abm7375
Publikováno v:
Cell Death and Differentiation
Axonal degeneration and neuronal cell death are fundamental processes in development and contribute to the pathology of neurological disease in adults. Both processes are regulated by BCL-2 family proteins which orchestrate the permeabilization of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425a17346e0ab2d3e73b9378af5b572c
https://doi.org/10.1038/s41418-020-00654-2
https://doi.org/10.1038/s41418-020-00654-2
Autor:
Elizabeth J. Osterlund, Nehad Hirmiz, Dang Nguyen, James M. Pemberton, Qiyin Fang, David W. Andrews
Publikováno v:
Journal of Biological Chemistry. 299:102863
The pro-apoptotic BH3-only endoplasmic reticulum (ER) resident protein BIK, positively regulates mitochondrial outer membrane permeabilization (MOMP), the point-of-no-return in apoptosis. It is generally accepted that BIK functions at a distance from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8c1ad2b2eaba6938b9f3607b4d6555
https://doi.org/10.1016/j.jbc.2022.102863
https://doi.org/10.1016/j.jbc.2022.102863
Autor:
James M. Pemberton, Linda Z. Penn, David W. Andrews, Santosh Hariharan, Philipp Mergenthaler, Corey Lourenco
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 2, p e1008630 (2021)
PLoS Computational Biology, Vol 17, Iss 2, p e1008630 (2021)
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d55774fc191ca2b6b81911e75c9b0c0
https://pubmed.ncbi.nlm.nih.gov/33617523
https://pubmed.ncbi.nlm.nih.gov/33617523
Autor:
David W. Andrews, Jialing Lin, Qian Liu, Dang Nguyen, Xiaoke Chi, Hetal Brahmbhatt, James M. Pemberton, Brian Leber, Zhi Zhang, Elizabeth J Osterlund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5d9195bdd01553fa821926258cef26
https://doi.org/10.7554/elife.44525.sa2
https://doi.org/10.7554/elife.44525.sa2