Zobrazeno 1 - 10
of 92
pro vyhledávání: '"James M McFarland"'
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reducing disparities is vital for equitable access to precision treatments in cancer. Socioenvironmental factors are a major driver of disparities, but differences in genetic variation likely also contribute. The impact of genetic ancestry o
Externí odkaz:
https://doaj.org/article/f5fc9a4be68842a79c2275a29dc90764
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Understanding the functional connectivity between brain regions and its emergent dynamics is a central challenge. Here we present a theory-experiment hybrid approach involving iteration between a minimal computational model and in vivo elect
Externí odkaz:
https://doaj.org/article/dfb912a0b83047bab7bacff5ae46a94b
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 7, p e1003143 (2013)
The computation represented by a sensory neuron's response to stimuli is constructed from an array of physiological processes both belonging to that neuron and inherited from its inputs. Although many of these physiological processes are known to be
Externí odkaz:
https://doaj.org/article/a43a7255d5de4c46a7e4935dd275b5f6
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21606 (2011)
Neocortical neurons show UP-DOWN state (UDS) oscillations under a variety of conditions. These UDS have been extensively studied because of the insight they can yield into the functioning of cortical networks, and their proposed role in putative memo
Externí odkaz:
https://doaj.org/article/f932d4b2ffc94fce9c83c50e5738ff74
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21408 (2011)
Cortical and hippocampal gamma oscillations have been implicated in many behavioral tasks. The hippocampus is required for spatial navigation where animals run at varying speeds. Hence we tested the hypothesis that the gamma rhythm could encode the r
Externí odkaz:
https://doaj.org/article/fb51d71ae0cf4ddb978dd1f1bb067d7d
Autor:
J. Michael Krill-Burger, Joshua M. Dempster, Ashir A. Borah, Brenton R. Paolella, David E. Root, Todd R. Golub, Jesse S. Boehm, William C. Hahn, James M. McFarland, Francisca Vazquez, Aviad Tsherniak
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer Dependency Map, to identify gene dependencies—genes whose loss of function reduces cell vi
Externí odkaz:
https://doaj.org/article/1c92c0bab42244fc81f9b12dd6f2049f
Autor:
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Publikováno v:
de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research
Nature Cancer, 4(5), 754-773. Nature Research
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
William C. Hahn, Francisca Vazquez, James M. McFarland, David E. Root, Steven A. Carr, Meagan E. Olive, Namrata D. Udeshi, Federica Piccioni, John Michael Krill-Burger, Joshua M. Dempster, Mariya Kazachkova, Nolan R. Bick, Alfredo Gonzalez, Nancy Dumont, Brian H. Shim, Sydney M. Moyer, Naomi Li, Lisa Leung, Linh He, Benjamin Gaeta, Ashir A. Borah, Tsukasa Shibue, Lisa D. Cervia
Systematic identification of signaling pathways required for the fitness of cancer cells will facilitate the development of new cancer therapies. We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fc76a0c251e4642a82d828d0e369b2
https://doi.org/10.1158/2159-8290.c.6549921.v1
https://doi.org/10.1158/2159-8290.c.6549921.v1
Autor:
William C. Hahn, Francisca Vazquez, James M. McFarland, David E. Root, Steven A. Carr, Meagan E. Olive, Namrata D. Udeshi, Federica Piccioni, John Michael Krill-Burger, Joshua M. Dempster, Mariya Kazachkova, Nolan R. Bick, Alfredo Gonzalez, Nancy Dumont, Brian H. Shim, Sydney M. Moyer, Naomi Li, Lisa Leung, Linh He, Benjamin Gaeta, Ashir A. Borah, Tsukasa Shibue, Lisa D. Cervia
Supplementary Figure S1 shows the strategy and result of co-essentiality module identificationfrom the DepMap CRISPR screen dataset and further characterization of the BIRC6 module. Supplementary Figure S2 shows the viability effect of BIRC6 depletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879d88026d2d97772a09ffcc4c904be6
https://doi.org/10.1158/2159-8290.22542432.v1
https://doi.org/10.1158/2159-8290.22542432.v1