Zobrazeno 1 - 10
of 50
pro vyhledávání: '"James M Lenhard"'
Autor:
Moshe Cohen-Kutner, Lena Khomsky, Michael Trus, Hila Ben-Yehuda, James M. Lenhard, Yin Liang, Tonya Martin, Daphne Atlas
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 447-456 (2014)
Diabetes is a high risk factor for dementia. High glucose may be a risk factor for dementia even among persons without diabetes, and in transgenic animals it has been shown to cause a potentiation of indices that are pre-symptomatic of Alzheimer′s
Externí odkaz:
https://doaj.org/article/ebbb4aa903a14ca4a2134e4c793007de
Autor:
James M. Lenhard, Amy K. Otto, Scott D. Siegel, Christine Perndorfer, Emily C. Soriano, Jean-Philippe Laurenceau, Howard Tennen, Jeffrey S. Gonzalez, Sy Miin Chow, Biing Jiun Shen
Publikováno v:
Ann Behav Med
Background Spouses often attempt to influence patients' diabetes self-care. Spousal influence has been linked to beneficial health outcomes in some studies, but to negative outcomes in others. Purpose We aimed to clarify the conditions under which sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ac062f605ea0d087ba8ec70923f4ff
https://doi.org/10.1093/abm/kaaa038
https://doi.org/10.1093/abm/kaaa038
Autor:
Michael Trus, James M. Lenhard, Moshe Cohen-Kutner, Lena Khomsky, Tonya Martin, Hila Ben-Yehuda, Daphne Atlas, Yin Liang
Publikováno v:
Redox Biology
Redox Biology, Vol 2, Iss C, Pp 447-456 (2014)
Redox Biology, Vol 2, Iss C, Pp 447-456 (2014)
Diabetes is a high risk factor for dementia. High glucose may be a risk factor for dementia even among persons without diabetes, and in transgenic animals it has been shown to cause a potentiation of indices that are pre-symptomatic of Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb84cbff1876074f4d6f40b3ee8f5f
Autor:
Shyh-Ming, Yang, Yuting, Tang, Rui, Zhang, Huajun, Lu, Gee-Hong, Kuo, Michael D, Gaul, Yaxin, Li, George, Ho, James G, Conway, Yin, Liang, James M, Lenhard, Keith T, Demarest, William V, Murray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6773-6776
A new series of urea-based, 4-bicyclic heteroaryl-piperidine derivatives as potent SCD1 inhibitors is described. The structure-activity relationships focused on bicyclic heteroarenes and aminothiazole-urea portions are discussed. A trend of dose-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96773dd83c3a3d36e9e45cbb21d3535c
https://doi.org/10.1016/j.bmcl.2013.09.096
https://doi.org/10.1016/j.bmcl.2013.09.096
Autor:
James M Lenhard
Publikováno v:
Current Pharmaceutical Design. 17:325-331
Since storage of excess fat in peripheral tissues is a contributing factor leading to obesity and type II diabetes, many investigators are studying the key lipid metabolizing enzymes found in adipose tissue as drug targets to reduce excess fat. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f67b07aeb6f4441013170ae5ea12c9
https://doi.org/10.2174/138161211795164185
https://doi.org/10.2174/138161211795164185
Autor:
Ling Lin, Chaozhong Cai, Christopher M. Flores, Timothy P Coogan, Edmund K. LeGrand, Ellen E. Codd, Raymond W. Colburn, Angelique Leone, Charles Y. Wang, Mcdonnell Mark E, Scott L. Dax, Michael R. Brandt, Stewart Bryant, Bart DeCorte, James J. McNally, John R. Mabus, Sui-Po Zhang, John R. Carson, Michael Kemmerer, Dennis J. Stone, James M Lenhard, Michael K. McMillian, Kristen M. Chevalier, Judith Baker
Publikováno v:
Toxicological Sciences. 117:493-504
The unexpected observation of a hyperglycemic effect of some tricycle-based delta opioid receptor (DOR) agonists led to a series of studies to better understand the finding. Single administration of two novel tricyclic DOR agonists dose dependently e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9776c107aa28aa0bdc15b9be77554703
https://doi.org/10.1093/toxsci/kfq200
https://doi.org/10.1093/toxsci/kfq200
Autor:
Fang Zhang, Dennis Rentzeperis, Francine M. Gregoire, Holly J. Clarke, Brian Edward Lavan, Thomas A. Gustafson, Svetlana Favelyukis, Dorothy D. Sears, L. Edward Clemens, James M. Lenhard, Yi Mu
Publikováno v:
Molecular Endocrinology. 23:975-988
MBX-102/JNJ39659100 (MBX-102) is in clinical development as an oral glucose-lowering agent for the treatment of type 2 diabetes. MBX-102 is a nonthiazolidinedione (TZD) selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5a0582832e3857944e294f2920342f
https://doi.org/10.1210/me.2008-0473
https://doi.org/10.1210/me.2008-0473
Autor:
Richard S. Strauss, Qingqin S. Li, Maria C. Athanasiou, Stephan Francke, James M. Lenhard, Yiping Zhan, Karel Konvicka
Publikováno v:
Pharmacogenetics and genomics. 26(2)
OBJECTIVE Clinical response to topiramate can vary greatly in obese patients. Identifying genetic variants associated with treatment response could help gain insight into the mechanism of action of topiramate. Little is known about the relationship b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68293bd854e81d14feff3c1d26b31cdd
https://pubmed.ncbi.nlm.nih.gov/26524290
https://pubmed.ncbi.nlm.nih.gov/26524290
Autor:
Aaron B. Miller, Steve Blanchard, Kate A. Dwornik, Dallas K. Croom, Robert T. Gampe, Tom G. Consler, James M. Lenhard, Olivia Ittoop, Valerie G. Montana, Randy K. Bledsoe, and Andrea Ayscue, Darryl Lynn Mcdougald, Curt D. Haffner, H. Eric Xu
Publikováno v:
Journal of Medicinal Chemistry. 47:2010-2029
A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37272a91a5f51d032982fc530dd7de0b
https://doi.org/10.1021/jm030565g
https://doi.org/10.1021/jm030565g
Publikováno v:
Advanced Drug Delivery Reviews. 54:1199-1212
Type 2 diabetes is associated with insulin resistance in peripheral tissues, such as muscle and fat, impaired glucose-stimulated insulin secretion from pancreatic beta-cells and elevated hepatic gluconeogenesis. Current pharmacotherapy does not adequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467423781d52c76e6aee5ab432777e52
https://doi.org/10.1016/s0169-409x(02)00092-3
https://doi.org/10.1016/s0169-409x(02)00092-3