Emerin deficiency drives MCF7 cells to an invasive phenotype

Autor: Emily Hansen, Christal Rolling, Matthew Wang, James M. Holaska

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract During metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps. Our lab showed invasive breast c

Externí odkaz: https://doaj.org/article/8fd52e3b1a9048d4b6daa6ed984a17e7

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

Autor: James M Holaska, Amy K Kowalski, Katherine L Wilson

Publikováno v: PLoS Biology, Vol 2, Iss 9, p E231 (2004)

X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts

Externí odkaz: https://doaj.org/article/f3d37424c6eb493ab31991629bc0f791

The nuclear envelope and metastasis

Autor: Emily Hansen, James M. Holaska

Publikováno v: Oncotarget. 14:317-320

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229e74d3f7eed8bd3daed25c4019c5d8
https://doi.org/10.18632/oncotarget.28375

Data from Defects in Emerin–Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis

Autor: James M. Holaska, Isabelle Mercier, Mallory C. Campbell, Chelsea A. McNamara, Alexandra G. Liddane

Nuclear envelope proteins play an important role in regulating nuclear size and structure in cancer. Altered expression of nuclear lamins are found in many cancers and its expression is correlated with better clinical outcomes. The nucleus is the lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3eb11bf0b46131006990c5d24812a54
https://doi.org/10.1158/1541-7786.c.6545135.v1

The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction

Autor: Wendy Lilián Gómez-Monsivais, James M. Holaska, Jesús Mauricio Ernesto Hernández-Méndez, Jhon Rivera-Monroy, Paulina Margarita Azuara-Medina, Jonathan J. Magaña, Raúl Argüello-García, Steve J. Winder, Bulmaro Cisneros, Feliciano Monterrubio-Ledezma, Ivette Martínez-Vieyra, Efraín Garrido, Alma Alamillo-Iniesta, Jazmin Huerta-Cantillo, Ricardo Mondragon-Gonzalez, Ian García-Aguirre, Fernando Navarro-Garcia, Andrea Brancaccio

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences (Online) 21 (2020): 1–20. doi:10.3390/ijms21175944
info:cnr-pdr/source/autori:Gomez-Monsivais W.L.; Monterrubio-Ledezma F.; Huerta-Cantillo J.; Mondragon-Gonzalez R.; Alamillo-Iniesta A.; Garcia-Aguirre I.; Azuara-Medina P.M.; Arguello-Garcia R.; Rivera-Monroy J.E.; Holaska J.M.; Hernandez-Mendez J.M.E.; Garrido E.; Magana J.J.; Winder S.J.; Brancaccio A.; Martinez-Vieyra I.; Navarro-Garcia F.; Cisneros B./titolo:The molecular basis and biologic significance of the ?-dystroglycan-emerin interaction/doi:10.3390%2Fijms21175944/rivista:International journal of molecular sciences (Online)/anno:2020/pagina_da:1/pagina_a:20/intervallo_pagine:1–20/volume:21
International Journal of Molecular Sciences, Vol 21, Iss 5944, p 5944 (2020)
Volume 21
Issue 17
Gómez-Monsiváis, W L, Monterrubio-Ledezma, F, Huerta-Cantillo, J, Mondragon-Gonzalez, R, Alamillo-Iniesta, A, García-Aguirre, I, Azuara-Medina, P M, Arguello-García, R, Rivera-Monroy, J E, Holaska, A M, Hernández-Méndez, J M E, Garrido, E, Javier Magaña, J, Winder, S, Brancaccio, A, Martínez-Vieyra, I, Navarro-Garcia, F & Cisneros, B 2020, ' The molecular basis and biological significance of the β-dystroglycan-emerin interaction ', International Journal of Molecular Sciences, vol. 21, no. 17, 5944 . https://doi.org/10.3390/ijms21175944

&beta
dystroglycan (&beta
DG) assembles with lamins A/C and B1 and emerin at the nuclear envelope (NE) to maintain proper nuclear architecture and function. To provide insight into the nuclear function of &beta
DG, we characterized the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8369a6bc8ba430d6991cf14c9a6c53
http://europepmc.org/articles/PMC7504044