Zobrazeno 1 - 10
of 141
pro vyhledávání: '"James M Hogle"'
Autor:
Han Chen, Ming F Lye, Christoph Gorgulla, Scott B Ficarro, Gregory D Cuny, David A Scott, Fan Wu, Paul W Rothlauf, Xiaoou Wang, Rosio Fernandez, Jean M Pesola, Sorin Draga, Jarrod A Marto, James M Hogle, Haribabu Arthanari, Donald M Coen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011781 (2023)
Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress complex (NEC) composed of two subunits, UL50 and UL53, whose interaction is crucial for viral rep
Externí odkaz:
https://doaj.org/article/de5854a14a0246dc98346d4f72583da0
Autor:
Pranav N M Shah, David J Filman, Krishanthi S Karunatilaka, Emma L Hesketh, Elisabetta Groppelli, Mike Strauss, James M Hogle
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008920 (2020)
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. T
Externí odkaz:
https://doaj.org/article/fff9a10cc1a745f58f879735bd89f47e
Autor:
Elisabetta Groppelli, Hazel C Levy, Eileen Sun, Mike Strauss, Clare Nicol, Sarah Gold, Xiaowei Zhuang, Tobias J Tuthill, James M Hogle, David J Rowlands
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006197 (2017)
Picornaviruses are non-enveloped RNA viruses that enter cells via receptor-mediated endocytosis. Because they lack an envelope, picornaviruses face the challenge of delivering their RNA genomes across the membrane of the endocytic vesicle into the cy
Externí odkaz:
https://doaj.org/article/319e73edff604deca97edacbdc918568
Autor:
Anusha Panjwani, Mike Strauss, Sarah Gold, Hannah Wenham, Terry Jackson, James J Chou, David J Rowlands, Nicola J Stonehouse, James M Hogle, Tobias J Tuthill
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004294 (2014)
Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the common cold, is a non-envel
Externí odkaz:
https://doaj.org/article/240f4074114e4f3b884aa622f49c189a
Autor:
Boerries Brandenburg, Lily Y Lee, Melike Lakadamyali, Michael J Rust, Xiaowei Zhuang, James M Hogle
Publikováno v:
PLoS Biology, Vol 5, Iss 7, p e183 (2007)
Viruses initiate infection by transferring their genetic material across a cellular membrane and into the appropriate compartment of the cell. The mechanisms by which animal viruses, especially nonenveloped viruses, deliver their genomes are only poo
Externí odkaz:
https://doaj.org/article/74b193bc36824441aaa25b3d3d8f4e5f
Autor:
Natalie J Kingston, Joseph S Snowden, Agnieszka Martyna, Mona Shegdar, Keith Grehan, Alison Tedcastle, Elaine Pegg, Helen Fox, Andrew J Macadam, Javier Martin, James M Hogle, David J Rowlands, Nicola J Stonehouse
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While initially anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6b0829e1b634e1f8b5dad2afac80f5
https://doi.org/10.1101/2023.01.30.526315
https://doi.org/10.1101/2023.01.30.526315
Publikováno v:
mBio
mBio, Vol 12, Iss 1 (2021)
mBio, Vol 12, Iss 1 (2021)
Genome transfer from a virus into a cell is a critical early step in viral replication. Enveloped viruses achieve the delivery of their genomes into the cytoplasm by merging the viral membrane with the cellular membrane via a conceptually simple mech
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio
mBio
While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers res
Autor:
Mike Strauss, James M. Hogle, Emma L. Hesketh, Krishanthi S. Karunatilaka, Elisabetta Groppelli, Pranav N.M. Shah, David J. Filman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008920 (2020)
PLoS Pathogens
PLoS Pathogens
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cb7a5eee6b694626f83656c8f7aa32
https://openaccess.sgul.ac.uk/id/eprint/112678/1/journal.ppat.1008920.pdf
https://openaccess.sgul.ac.uk/id/eprint/112678/1/journal.ppat.1008920.pdf
Publikováno v:
Journal of the American Chemical Society. 140:10639-10643
Here we present a modular method for manufacturing large-sized nanodiscs using DNA-origami barrels as scaffolding corrals. Large-sized nanodiscs can be produced by first decorating the inside of DNA barrels with small lipid-bilayer nanodiscs, which o