Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James M Hinson"'
Autor:
Zhonglin Hao, Alexander Drilon, Everardus Otto Orlemans, Stephen V. Liu, Martin Gutierrez, Robin Guo, James M Hinson, Giuseppe Giaccone, Mark G. Kris, Christie Hilton
Publikováno v:
Lung Cancer
Objectives Single-agent heat shock protein 90 (HSP90) inhibition has demonstrated activity in oncogene-driven non-small cell and small cell lung cancers. SNX-5422 is an oral HSP90 inhibitor with increased activity in vitro with the addition of carbop
Akademický článek
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Autor:
David Y. Huang, George Rappard, Carmelo Graffagnino, Jennifer A Elder, Ronald F Budzik, Yazan J. Alderazi, James M Hinson, Neal Rutledge, Sean I Savitz, William Likosky, Dileep Yavagal, Ronald Tarrel, Peng R Chen
Publikováno v:
Circulation. 139:192-205
Background: Ischemic stroke has no approved treatments to enhance recovery. ALD-401 is an enriched population of aldehyde dehydrogenase-bright stem cells, capable of reducing neurological deficits in animal models. The primary objective of this trial
Autor:
Hannah Storrie White, Elizabeth Nieman, M. Fiordalisi, Andrew E. Balber, Alan Nguyen, N. Meadows, D. Hickerson, Tracy Gentry, Sandra J. Foster, James M. Hinson
Publikováno v:
Cytotherapy. 16:1545-1557
Background aims Delivery of cell-based therapies through the carotid artery with the use of an intra-arterial catheter could introduce aggregates and cause focal ischemia in the brain. We developed a pulse-width flow cytometry method for aggregate de
Autor:
Everardus Otto Orlemans, Christie Hilton, Alexander Drilon, Martin Gutierrez, Zhonglin Hao, James M Hinson, Giuseppe Giaccone, Stephen V. Liu
Publikováno v:
Journal of Clinical Oncology. 35:e20622-e20622
e20622 Background: SNX-5422 is an orally bioavailable pro-drug of SNX-2112, a highly potent and selective heat shock protein (Hsp) 90 inhibitor with synergy with platinum and paclitaxel. In this study, SNX-5422 + C/P followed by SNX-5422 maintenance
Autor:
Peter M. Voorhees, Anand Jillela, Brett E. Houk, Nicoletta Brega, Nishitha Reddy, James M. Hinson
Publikováno v:
Clinical lymphoma, myelomaleukemia. 13(4)
Background Heat shock protein (HSP)90 regulates the function of proteins responsible for cell growth and survival, is overexpressed in many cancers and is an attractive therapeutic target. We undertook a phase 1 trial of PF-04929113 (SNX-5422), a nov
Autor:
Graham C. Scott, Patrick R. Quigley, Kent L. Christopher, Riley R Scott, James M. Hinson, Michael H. Metzler
Publikováno v:
Chest. 104:1199-1202
Previous studies have shown transtracheal delivery of low-flow oxygen (TTO) decreases inspired minute ventilation (Veinsp) and have postulated that this would result in a decrease in the work of breathing (WOB). We hypothesized that a fall in central
Publikováno v:
Respiration. 60:51-57
Infusion of exogenous dopamine has been shown to alter both the hypoxic and the hypercapnic ventilatory response, but its effects on the hypoxic and the hypercapnic cardiac response have not been reported. The purpose of this study was to determine i
Autor:
Martin Gutierrez, Alexander Drilon, Stephen V. Liu, Everardus Otto Orlemans, James M Hinson, Bruno Fang, Harry D. Harper, Giuseppe Giaccone, Jimmy Ruiz
Publikováno v:
Journal of Clinical Oncology. 33:e19033-e19033
e19033 Background: SNX-5422 is an orally bioavailable pro-drug of SNX-2112, a highly potent and selective Hsp90 inhibitor with preclinical anti-tumor activity in lung cancer models and synergy with platinum and taxane compounds. Carboplatin/paclitaxe
Autor:
James M. Hinson, Jack J. Curtis, Stephen R. Hazelrigg, Theresa M. Boley, Joel A. Johnson, Rodney J. Landreneau
Publikováno v:
The Annals of Thoracic Surgery. 51:473-475
The indications for and preferred approaches to operative stabilization of posttraumatic chest wall instability are uncertain. We suggest this simple, rapid, and effective approach to surgical stabilization by Luque rod strutting of the flail segment