Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James M Fulcher"'
Autor:
Han Han, James M Fulcher, Venkata P Dandey, Janet H Iwasa, Wesley I Sundquist, Michael S Kay, Peter S Shen, Christopher P Hill
Publikováno v:
eLife, Vol 8 (2019)
Many AAA+ ATPases form hexamers that unfold protein substrates by translocating them through their central pore. Multiple structures have shown how a helical assembly of subunits binds a single strand of substrate, and indicate that translocation res
Externí odkaz:
https://doaj.org/article/d6a79491d33f44f68941cb6081b14f95
Autor:
Matthew A Sdano, James M Fulcher, Sowmiya Palani, Mahesh B Chandrasekharan, Timothy J Parnell, Frank G Whitby, Tim Formosa, Christopher P Hill
Publikováno v:
eLife, Vol 6 (2017)
We determined that the tandem SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rather than the expected sites in its heptad repeat domain. The 4 nM binding affinity requires phosphorylation at Rpb1 S1493
Externí odkaz:
https://doaj.org/article/e18ab755fcdb496192364c8e719f794e
Autor:
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, James M. Fulcher, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7d8661c095f542b3a5b93707671c7539
Autor:
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, James M. Fulcher, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionNeutrophil extracellular traps (NETs) clear pathogens but may contribute Q8 pathogenically to host inflammatory tissue damage during sepsis. Innovative therapeutic agents targeting NET formation and their potentially harmful collateral ef
Externí odkaz:
https://doaj.org/article/95613aabff2141a381bede33f379a8d5
Autor:
Junho Park, Fengchao Yu, James M. Fulcher, Sarah M. Williams, Kristin Engbrecht, Ronald J. Moore, Geremy C. Clair, Vladislav Petyuk, Alexey I. Nesvizhskii, Ying Zhu
Publikováno v:
Analytical Chemistry. 95:1888-1898
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1725be6df861350f0233bc3a765cd12
https://doi.org/10.1021/acs.analchem.2c03739
https://doi.org/10.1021/acs.analchem.2c03739
Autor:
Yi-Chun Chen, Austin J. Taylor, James M. Fulcher, Adam C. Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L.C. Wrightson, Kenny Fok, Annette E. Patterson, Ramon I. Klein-Geltink, Patrick E. MacDonald, Wei-Jun Qian, C. Bruce Verchere
Carboxypeptidase E (CPE) facilitates the conversion of prohormones into mature hormones and is highly expressed in multiple neuroendocrine tissues. Carriers ofCPEmutations have elevated plasma proinsulin and develop severe obesity and hyperglycemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa89041e5288a6d6c1b4079bc4debdb
https://doi.org/10.1101/2022.10.20.512925
https://doi.org/10.1101/2022.10.20.512925
Autor:
Mowei Zhou, James M. Fulcher, Kevin J. Zemaitis, David J. Degnan, Yen-Chen Liao, Marija Veličković, Dušan Veličković, Lisa M. Bramer, William R Kew, Gary Stacey, Ljiljana Paša-Tolić
Publikováno v:
Frontiers in Analytical Science. 2
Proteomic methods have been widely used to study proteins in complex biological samples to understand biological molecular mechanisms. Most well-established methods (known as bottom-up proteomics, BUP) employ an enzymatic digestion step to cleave int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a281a39be0299b007977e7130c169d2
https://doi.org/10.3389/frans.2022.1012707
https://doi.org/10.3389/frans.2022.1012707
Autor:
James M Fulcher
In this protocol, we describe a detailed procedure for high-resolution top-down proteomic analysis of human pancreatic and kidney tissue sections using a spatial proteomic platform by combining laser capture microdissection (LCM), microPOTS (microdro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ec889ab7ca79ea6ff3f454ba01b3e3
https://doi.org/10.17504/protocols.io.ewov1nrz7gr2/v1
https://doi.org/10.17504/protocols.io.ewov1nrz7gr2/v1
Autor:
Yen-Chen Liao, James M. Fulcher, David J. Degnan, Sarah M. Williams, Lisa M. Bramer, Dušan Veličković, Kevin J. Zemaitis, Marija Veličković, Ryan L. Sontag, Ronald J. Moore, Ljiljana Paša-Tolić, Ying Zhu, Mowei Zhou
Publikováno v:
Molecularcellular proteomics : MCP.
Conventional proteomic approaches measure the averaged signal from mixed cell populations or bulk tissues, leading to the dilution of signals arising from subpopulations of cells that might serve as important biomarkers. Recent developments in bottom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df4e86cc152facdccae1b54919de3e2
https://pubmed.ncbi.nlm.nih.gov/36603806
https://pubmed.ncbi.nlm.nih.gov/36603806
Autor:
D. C. Bennett, Mowei Zhou, Liljiana Pasa-Tolic, A. Makaju, Vladislav A. Petyuk, James M Fulcher, Wei-Jun Qian, Ronald J. Moore, P. L. De Jager
Publikováno v:
J Proteome Res
Proteomic investigations of Alzheimer’s and Parkinson’s disease have provided valuable insights into neurodegenerative disorders. Thus far, these investigations have largely been restricted to bottom-up approaches, hindering the degree to which o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c4bbadfb090cd5eca76d44e3c96d14
https://doi.org/10.1021/acs.jproteome.1c00049
https://doi.org/10.1021/acs.jproteome.1c00049