Zobrazeno 1 - 10
of 120
pro vyhledávání: '"James M Cunningham"'
Autor:
May Kwang-Mei Wang, Tao Ren, Hu Liu, Sun-Young Lim, Kyungae Lee, Anna Honko, Huanying Zhou, Julie Dyall, Lisa Hensley, Ashley K Gartin, James M Cunningham
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007322 (2018)
Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to analyze the mechanism of entry. Using a photo-reactive analog that
Externí odkaz:
https://doaj.org/article/818a1fdb391a4e078bd24d33d234937b
Autor:
Jason G Smith, James M Cunningham
Publikováno v:
PLoS Pathogens, Vol 3, Iss 12, p e198 (2007)
According to current models of retrovirus infection, receptor binding to the surface subunit (SU) of the envelope glycoprotein (Env) triggers a conformational change in the transmembrane subunit (TM) that mediates virus fusion to cell membranes. To u
Externí odkaz:
https://doaj.org/article/83a121dcb80b48e1a8ee66bebac040c0
Autor:
James M Cunningham, Sergey V. Mikhalovsky, Liana R. Azizova, Mykola Borysenko, Lyuba Mikhalovska, Kostiantyn Kulyk
Publikováno v:
Journal of Materials Chemistry B. 8:4267-4277
Nitric oxide NO, mediates inflammatory and thrombotic processes and designing biomaterials capable of releasing NO in contact with biological tissues is considered to be a major factor aimed at improving their bio- and haemocompatibility and antibact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552a04ad412113cffdc06bec496a7a38
https://doi.org/10.1039/d0tb00137f
https://doi.org/10.1039/d0tb00137f
Autor:
Marceline, Côté, James M, Cunningham
Publikováno v:
Virologie (Montrouge, France). 16(3)
Ebola and Marburg viruses cause outbreaks of highly lethal infection in central Africa. In the last few years, rapid progress has been made in understanding how these viruses are transmitted and spread. These studies show that the glycoprotein GP tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d36f8236fa4ff9eae72e06899b66f0e
https://pubmed.ncbi.nlm.nih.gov/33065873
https://pubmed.ncbi.nlm.nih.gov/33065873
Autor:
Laura I. Prugar, Mariano Sanchez-Lockhart, Jennifer M. Brannan, Katie Caviness, Jens H. Kuhn, Veronica Soloveva, John M. Dye, James M. Cunningham, Elena Postnikova, Russell R. Bakken, Shuiqing Yu, Courtney L. Finch, Hu Liu, Gustavo Palacios, Brett Beitzel, Nicholas Di Paola, David Kimmel, Jeffrey R. Kugelman, Sheli R. Radoshitzky
Publikováno v:
Viruses, Vol 13, Iss 2010, p 2010 (2021)
Viruses
Volume 13
Issue 10
Viruses
Volume 13
Issue 10
Biosafety, biosecurity, logistical, political, and technical considerations can delay or prevent the wide dissemination of source material containing viable virus from the geographic origin of an outbreak to laboratories involved in developing medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c12482a5709371be87cd23d8d7d0b1
https://doi.org/10.3390/v13102010
https://doi.org/10.3390/v13102010
Autor:
Carmen Priolo, Harilaos Filippakis, Catherine Gutierrez, Barbara Ogorek, Alexander J. Valvezan, Damir Khabibullin, James M. Cunningham, Julie Nijmeh, Nicola Alesi, Elizabeth P. Henske
Publikováno v:
Oncotarget
// Harilaos Filippakis 1 , Nicola Alesi 1 , Barbara Ogorek 1 , Julie Nijmeh 1 , Damir Khabibullin 1 , Catherine Gutierrez 1 , Alexander J. Valvezan 2 , James Cunningham 3 , Carmen Priolo 1 and Elizabeth P. Henske 1 1 Division of Pulmonary and Critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02cd9ef2e7157ecba4124b5f5f12e62
https://doi.org/10.18632/oncotarget.17485
https://doi.org/10.18632/oncotarget.17485
Publikováno v:
Cell Host & Microbe. 21:367-375
Ebola virus (EBOV) infection is characterized by sporadic outbreaks caused by zoonotic transmission. Fixed changes in amino acid sequence, such as A82V in the EBOV glycoprotein (GP) that occurred early in the 2013-16 epidemic, are suspected to confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070aa87598898e759000547c36f0953f
https://doi.org/10.1016/j.chom.2017.02.002
https://doi.org/10.1016/j.chom.2017.02.002
Autor:
Sirano Dhe-Paganon, Theresa D. Manz, Lewis C. Cantley, Scott B. Ficarro, Hyuk-Soo Seo, Marcia N. Paddock, Mingfeng Hao, Nathanael S. Gray, Tinghu Zhang, Baishan Jiang, Hyeseok Shim, Jarrod A. Marto, Nicholas Kwiatkowski, Diana G. Wang, Christopher M. Browne, James M. Cunningham, T. Jonathan Yang, Sindhu Carmen Sivakumaren, Mark R. Lundquist, Fleur M. Ferguson, Pranav Krishnan
SummaryThe PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc1b0cef434a17aa0f69572842f5ff5
Autor:
Nathanael S. Gray, Lewis C. Cantley, Christopher M. Browne, Theresa D. Manz, Jarrod A. Marto, Hyeseok Shim, Pranav Krishnan, Diana G. Wang, Scott B. Ficarro, Nicholas Kwiatkowski, James M. Cunningham, Mark R. Lundquist, Fleur M. Ferguson, Hyuk-Soo Seo, Mingfeng Hao, Marcia N. Paddock, T. Jonathan Yang, Sindhu Carmen Sivakumaren, Baishan Jiang, Sirano Dhe-Paganon, Tinghu Zhang
Publikováno v:
Cell Chem Biol
The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. Here, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c61db14f9907d78cc5960d931fcf67
https://doi.org/10.1016/j.chembiol.2020.02.003
https://doi.org/10.1016/j.chembiol.2020.02.003
Autor:
Anders M. Näär, Andreas Petri, Alexandre Wagschal, Jessica Chery, Sakari Kauppinen, James M. Cunningham, Sun-Young Lim, Shobha Vasudevan
Publikováno v:
Chery, J, Petri, A, Wagschal, A, Lim, S-Y, Cunningham, J, Vasudevan, S, Kauppinen, S & Näär, A M 2018, ' Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1 ', Nucleic Acid Therapeutics, vol. 28, no. 5, pp. 273-284 . https://doi.org/10.1089/nat.2018.0722
The Ebola virus is a zoonotic pathogen that can cause severe hemorrhagic fever in humans, with up to 90% lethality. The deadly 2014 Ebola outbreak quickly made an unprecedented impact on human lives. While several vaccines and therapeutics are under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ad502849351497ecc6d08d89d824e9
https://europepmc.org/articles/PMC6425983/
https://europepmc.org/articles/PMC6425983/