Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James M Chapman"'
Autor:
Hala O El-Mesallamy, Hekmat M El Magdoub, James M Chapman, Nadia M Hamdy, Mona F Schaalan, Lamiaa N Hammad, Sondra H Berger
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193810 (2018)
Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to
Externí odkaz:
https://doaj.org/article/c969d40cc3eb4e17b48edb20133d05c3
Publikováno v:
TransfusionREFERENCES. 62(9)
A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti-A and anti-B antibodies are known to cause positive DATs, the extent this occurs followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f4cf16328466d4392404181c09974f
https://pubmed.ncbi.nlm.nih.gov/35836408
https://pubmed.ncbi.nlm.nih.gov/35836408
Publikováno v:
Transfusion and Apheresis Science. :103622
Patients undergoing recurrent platelet transfusions can become refractory to these transfusions. Platelet antibody screens (Immucor), platelet crossmatching assays (Immucor), and HLA antibody testing are commonly used to test these patients. The rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3ace8421e60fe25bbf1a932105a87e
https://doi.org/10.1016/j.transci.2022.103622
https://doi.org/10.1016/j.transci.2022.103622
Autor:
James R. Hébert, Eric W. Smith, Jin Zhang, Daniela Nitcheva, Chadi Azzi, Carryn H. Purdon, James M. Chapman
Publikováno v:
Carcinogenesis. 27(1)
Environmental influences may affect carcinogen absorption and residency in the tissues of the aero-digestive tract. We quantified the effect of ethanol and menthol on the rates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1818cc376ee18b89cf3fb179db6a1be8
https://pubmed.ncbi.nlm.nih.gov/16000402
https://pubmed.ncbi.nlm.nih.gov/16000402
Autor:
Robert W. Curley, James M. Chapman
Publikováno v:
Protein expression and purification. 1(1)
An affinity chromatographic matrix that purifies cellular retinoic acid-binding protein to near homogeneity from rat testes cytosol has been developed. The three-step procedure includes an acid precipitation, a batch treatment with CM Bio-Gel, and af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e16b96ce2df6e1140f9b03c6de409ba
https://pubmed.ncbi.nlm.nih.gov/1967079
https://pubmed.ncbi.nlm.nih.gov/1967079
Publikováno v:
Pharmaceutical Research. :63-68
A series of benzenetricarboxylic acids was shown to be potent hypolipidemic agents in rodents. Terephthalic acid proved to be one of the more potent agents, lowering serum cholesterol 42% and serum triglyceride 33 % at 20 mg/kg/day for 16 days. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d52646b32fdddb27fed1819eada02a
https://doi.org/10.1023/a:1016399213993
https://doi.org/10.1023/a:1016399213993
Publikováno v:
Pharmaceutical Research. :93-101
A series of substituted 2,3-dihydrophthalazine-l,4-dione derivatives as well as the corresponding N,N-diaminophthalamides were prepared and were demonstrated to have potent hypolipidemic activity, lowering both serum triglyceride and cholesterol leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230f5cf1a69404b631b056afc2adcb7b
https://doi.org/10.1023/a:1016341403244
https://doi.org/10.1023/a:1016341403244
Publikováno v:
Pharmaceutical Research. :286-289
Homophthalimide and a series of N-alkyl-substituted derivatives were investigated to determine their ability to lower serum cholesterol and triglyceride levels in mice. At 20 mg/kg/day these agents were equally potent or more potent than clofibrate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30c7334709354e5cf544ae78a8e9d31
https://doi.org/10.1023/a:1016311418691
https://doi.org/10.1023/a:1016311418691
Autor:
James M. Chapman, Robert W. Curley
Publikováno v:
Journal of Biochemical and Biophysical Methods. 19:287-300
Retinol-binding protein has been purified from rabbit serum by a new affinity chromatographic phase. Human retinol-binding protein has been shown to bind with vitamin A derivatives and certain other terpenoids. Consequently, this affinity method is b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757b1aa1c0a76d76408ca40b49031f02
https://doi.org/10.1016/0165-022x(89)90060-2
https://doi.org/10.1016/0165-022x(89)90060-2
Publikováno v:
Journal of Pharmaceutical Sciences. 72:845-851
Phthalimide analogues have been shown to effectively lower serum cholesterol and triglyceride levels in rats and mice. The mode of action of these agents was not to suppress the appetite of animals, but rather to reduce the activities of key enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc162100d252e6694278752640662bd
https://doi.org/10.1002/jps.2600720803
https://doi.org/10.1002/jps.2600720803