Zobrazeno 1 - 10
of 80
pro vyhledávání: '"James M Burke"'
Autor:
James M Burke, Nina Ripin, Max B Ferretti, Laura A St Clair, Emma R Worden-Sapper, Fernando Salgado, Sara L Sawyer, Rushika Perera, Kristen W Lynch, Roy Parker
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010930 (2022)
The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune response to destroy host and viral RNA to ultimately reduce viral gene expression. Herein, we show that RNase L and RNase L-mediated mRNA decay are primarily localiz
Externí odkaz:
https://doaj.org/article/9331648f7c5c4287a70e31fde9e1b2f9
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the virus uses “host shut-off” sys
Externí odkaz:
https://doaj.org/article/27febcd34e5549a295e9f3c410559f9d
Autor:
Rodney P Kincaid, James M Burke, Jennifer C Cox, Ethel-Michele de Villiers, Christopher S Sullivan
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003818 (2013)
Torque teno viruses (TTVs) are a group of viruses with small, circular DNA genomes. Members of this family are thought to ubiquitously infect humans, although causal disease associations are currently lacking. At present, there is no understanding of
Externí odkaz:
https://doaj.org/article/46387cb4996e430e83a7d1e2200a2ecf
Autor:
Renee Cusic, James M Burke
Oligoadenylate synthetase 3 (OAS3) and Ribonuclease L (RNase L) are components of a mammalian RNA decay pathway that is critical for combating viral infection. Nevertheless, the subcellular localization of OAS3 and RNase L during the antiviral respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd374c3792b4849d41a41006117854c4
https://doi.org/10.1101/2023.05.30.542827
https://doi.org/10.1101/2023.05.30.542827
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mammalian cells respond to dsRNA in multiple manners. One key response to dsRNA is the activation of PKR, an eIF2α kinase, which triggers translational arrest and the formation of stress granules. However, the process of PKR activation in cells is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae56b5e6587ea6c32c71de03138112d0
https://doi.org/10.1073/pnas.2204235119
https://doi.org/10.1073/pnas.2204235119
Publikováno v:
Journal of Environmental Protection. 11:332-343
A common issue with filters designed to remove nutrients from runoff is their reduced effectiveness in high-flow conditions. To overcome this challenge, it was determined that nutrient removal from broiler-house fan dust could be more effective if nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4cf03622e6759127529226381e4796
https://doi.org/10.4236/jep.2020.114019
https://doi.org/10.4236/jep.2020.114019
Publikováno v:
The EMBO Journal. 41
Numerous membrane-less organelles, composed of a combination of RNA and proteins, are observed in the nucleus and cytoplasm of eukaryotic cells. These RNP granules include stress granules (SGs), processing bodies (PBs), Cajal bodies, and nuclear spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4bb9036ab8359906b97628953598eb
https://doi.org/10.15252/embj.2021110137
https://doi.org/10.15252/embj.2021110137
Publikováno v:
Journal of Cell Science. 135
To rapidly adapt to stresses such as infections, cells have evolved several mechanisms, which include the activation of stress response pathways and the innate immune response. These stress responses result in the rapid inhibition of translation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0ba776a90d93bd5611642c1df58ec0
https://doi.org/10.1242/jcs.259194
https://doi.org/10.1242/jcs.259194
Autor:
James M. Burke, Nina Ripin, Max B. Ferretti, Laura A. St Clair, Emma R. Worden-Sapper, Sara L. Sawyer, Rushika Perera, Kristen W. Lynch, Roy Parker
The antiviral endoribonuclease, RNase L, is a vital component of the mammalian innate immune response that destroys host and viral RNA to reduce viral gene expression. Herein, we show that a consequence of RNase L-mediated decay of cytoplasmic host R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32261b61a8f4c6b5d6d6546c81c993c7
https://doi.org/10.1101/2022.01.28.478180
https://doi.org/10.1101/2022.01.28.478180