Zobrazeno 1 - 10
of 112
pro vyhledávání: '"James M Briggs"'
Autor:
Patrick Cherubin, Maria Camila Garcia, David Curtis, Christopher B T Britt, John W Craft, Helen Burress, Chris Berndt, Srikar Reddy, Jessica Guyette, Tianyu Zheng, Qun Huo, Beatriz Quiñones, James M Briggs, Ken Teter
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166477 (2016)
Cholera toxin (CT) is an AB-type protein toxin that contains a catalytic A1 subunit, an A2 linker, and a cell-binding B homopentamer. The CT holotoxin is released into the extracellular environment, but CTA1 attacks a target within the cytosol of a h
Externí odkaz:
https://doaj.org/article/933c0e1eb61a4f92a8eea8786528af62
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75395 (2013)
The lactonase enzyme (AiiA) produced by Bacillus thuringiensis serves to degrade autoinducer-1 (AI-1) signaling molecules in what is an evolved mechanism by which to compete with other bacteria. Bioassays have been previously performed to determine w
Externí odkaz:
https://doaj.org/article/89fd28380d874b78beed0b14bb18732c
Autor:
Yuemin Liu, Hana F. Sulaiman, Bruce R. Johnson, Rulong Ma, Yunxiang Gao, Harshica Fernando, Ananda Amarasekara, Andrea Ashley-Oyewole, Huajun Fan, Heaven N. Ingram, James M. Briggs
Publikováno v:
Computational biology and chemistry. 102
Intermolecular interaction between key residue N501 of the epitope on SARS-CoV-2 RBD and screening antibody B38 was studied using the QM/MM and QM approach. The QM/MM optimized geometry shows that angle X-H---Y is 165° for O-H---O between mAb light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072b064d7316592cf87041ca12ca38ca
https://pubmed.ncbi.nlm.nih.gov/36610304
https://pubmed.ncbi.nlm.nih.gov/36610304
Autor:
Kasuni Thawalama Gamage, Shivangi Srivastava, Jerry O. Ebalunode, Chin-Yo Lin, Carly S. Filgueira, Sridevi Addanki, James M. Briggs, Jan-Åke Gustafsson, Scott Widmann, Husna Karaboga, Scott R. Gilbertson, Zahra Mazhar, Wentao Huang
Publikováno v:
ACS Chemical Biology. 15:2916-2928
Pancreatic ductal adenocarcinoma (PDAC) is the predominant form of pancreatic cancer. PDACs harbor oncogenic mutations in the KRAS gene, and ongoing efforts to directly target its mutant protein product to inhibit tumor growth are a priority not only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037e096a657d22c105c42bd30dc3dda6
https://doi.org/10.1021/acschembio.0c00546
https://doi.org/10.1021/acschembio.0c00546
Autor:
Binh Vu, Atul Goyal, Ujwal Patil, Richard C. Willson, Vijay Maranholkar, Yanyun Liu, Katerina Kourentzi, James M. Briggs
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Antibodies and Fc fusion proteins are a rapidly growing class of pharmaceuticals. Cell culture and purification process development and operation require frequent measurement of product concentrations, commonly by complex enzyme-linked immunosorbent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b91dd277addd823fdae1202ccf407c7
http://europepmc.org/articles/PMC8525972
http://europepmc.org/articles/PMC8525972
Autor:
Omar Abousaway, Daniel Lim, Zeinab Moussa, James Byrnes, Pragya Manandhar, James M. Briggs, Mehmet Sen, Collins Aboagye, Zahra Mazhar, Tannon Yu
Publikováno v:
Cell reports. 40(8)
SummaryAllosteric activation and silencing of leukointegrins transpire through highly complex structural changes between and within domains, mediating integrin affinity and bidirectional allostery relay. However, the landscape of these conformational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5887a5dcd10d26967eaa7475a7dac10b
https://pubmed.ncbi.nlm.nih.gov/36001965
https://pubmed.ncbi.nlm.nih.gov/36001965
Autor:
Robert J. Schwartz, Robert M. Bryan, John W. Craft, Reza Abbasgholizadeh, Anton Agarkov, Warren E. Zimmer, James M. Briggs, Scott R. Gilbertson, Robert O Fox, Hua Zhang, Steven J. Bark
Publikováno v:
Experimental Biology and Medicine. 244:940-951
Rho-activated kinases (ROCKs) regulate many cellular functions such as proliferation, migration, and smooth muscle contractility, but they are also associated with pathogenesis of many human diseases such as heart failure and hypertension. We used ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d936a8eb2c4ca8122ac619a06ca9505b
https://doi.org/10.1177/1535370219849581
https://doi.org/10.1177/1535370219849581
Publikováno v:
Journal of Molecular Graphics and Modelling. 88:104-120
Quorum sensing is a cell to cell signaling mechanism that enables them to coordinate their behaviors in a density-dependent manner mediated by small diffusible signaling molecules, which can control the virulence and biofilm gene expression in many G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509b5c065f224a25efbf59b281d2a4da
https://doi.org/10.1016/j.jmgm.2019.01.006
https://doi.org/10.1016/j.jmgm.2019.01.006
Autor:
James M. Briggs, Lourival Rodrigues de Sousa Neto, Guedmiller S. Oliveira, Gisela B.R.F. Silva, Eduardo de Faria Franca, Yanyun Liu, Luiz C. G. Freitas, Ariana de Souza Moraes, Fabio L. Leite, Roberto Ribeiro Faria, Jéssica Cristiane Magalhães Ierich
Publikováno v:
Journal of Molecular Graphics and Modelling. 86:219-227
Experimental results for the antibody known as immunoglobulin G – IgG interacting with phenobarbital were obtained via atomic force microscopy (AFM) and thereafter investigated using computer simulation modeling tools. Using molecular dynamics simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24718cfaa3d5fdadd543b3d92b2cc76
https://doi.org/10.1016/j.jmgm.2018.10.012
https://doi.org/10.1016/j.jmgm.2018.10.012
Autor:
Xiongbin Lu, Lakshmi Reddy Bollu, Na Xian, Fei Su, James M. Briggs, Yunlu Xu, Zhang Weihua, Rintu Thomas, Bing Wu, Michael A. Rea, Rajasekhara Reddy Katreddy, Shivangi Srivastava, Qingyuan Zhang, Gangxiong Huang, Yubing Dai
Publikováno v:
Oncogenesis, Vol 7, Iss 1, Pp 1-13 (2018)
Oncogenesis
Oncogenesis
The oncogenic epidermal growth factor receptor (EGFR) is commonly overexpressed in solid cancers. The tyrosine kinase activity of EGFR has been a major therapeutic target for cancer; however, the efficacy of EGFR tyrosine kinase inhibitors to treat c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e8bc9e5b4ed0a905013f25d47639f4
http://link.springer.com/article/10.1038/s41389-017-0021-7
http://link.springer.com/article/10.1038/s41389-017-0021-7