Zobrazeno 1 - 10
of 157
pro vyhledávání: '"James M Brewer"'
Autor:
Owain R Millington, Vivienne B Gibson, Catherine M Rush, Bernd H Zinselmeyer, R Stephen Phillips, Paul Garside, James M Brewer
Publikováno v:
PLoS Pathogens, Vol 3, Iss 10, Pp 1380-1387 (2007)
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous anti
Externí odkaz:
https://doaj.org/article/6c6e1c6e87f9459890b2c00832c88a0b
Autor:
Robert A Benson, Megan KL MacLeod, Benjamin G Hale, Agapitos Patakas, Paul Garside, James M Brewer
Publikováno v:
eLife, Vol 4 (2015)
The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection i
Externí odkaz:
https://doaj.org/article/323f359a597c418eb6ade14903776202
Autor:
Jonathan A Coles, Elmarie Myburgh, Ryan Ritchie, Alana Hamilton, Jean Rodgers, Jeremy C Mottram, Michael P Barrett, James M Brewer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003714 (2015)
Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes meningoencephalitis. We have videoed the cortical meninges and superficial parenchyma of C56BL/6 reporter
Externí odkaz:
https://doaj.org/article/4f5c286785a64ef1b7a1deb687983e4d
Autor:
Tovah N Shaw, Phillip J Stewart-Hutchinson, Patrick Strangward, Durga B Dandamudi, Jonathan A Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M Brewer, Kevin N Couper, Michael L Dustin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005210 (2015)
There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the mechanisms through which they medi
Externí odkaz:
https://doaj.org/article/3f2002c434bb45ddb65f22c9102068f5
Autor:
Elmarie Myburgh, Jonathan A Coles, Ryan Ritchie, Peter G E Kennedy, Alex P McLatchie, Jean Rodgers, Martin C Taylor, Michael P Barrett, James M Brewer, Jeremy C Mottram
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2384 (2013)
HUMAN AFRICAN TRYPANOSOMIASIS (HAT) MANIFESTS IN TWO STAGES OF DISEASE: firstly, haemolymphatic, and secondly, an encephalitic phase involving the central nervous system (CNS). New drugs to treat the second-stage disease are urgently needed, yet test
Externí odkaz:
https://doaj.org/article/d8f63ebc485e4ac5958df2b230b0fd99
Autor:
Agapitos Patakas, Robert A Benson, David R Withers, Paola Conigliaro, Iain B McInnes, James M Brewer, Paul Garside
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49715 (2012)
Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell respons
Externí odkaz:
https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d92
Autor:
Teerawit Audshasai, Jonathan A. Coles, Stavros Panagiotou, Shadia Khandaker, Hannah E. Scales, Morten Kjos, Murielle Baltazar, Julie Vignau, James M. Brewer, Aras Kadioglu, Marie Yang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The entry routes and translocation mechanisms of microorganisms or particulate materials into the central nervous system remain obscure We report here that Streptococcus pneumoniae (pneumococcus), or polystyrene microspheres of similar size,
Externí odkaz:
https://doaj.org/article/a69df22b4cba440db00265f14bfb2761
Publikováno v:
Discovery Immunology. 2
Public interest in vaccines is at an all-time high following the SARS-CoV-2 global pandemic. Currently, over 6 billion doses of various vaccines are administered globally each year. Most of these vaccines contain Aluminium-based adjuvants (alum), whi
Autor:
Pascale Wehr, Daniela Sieghart, Shaima Al Khabouri, György Nagy, Michael Bonelli, Gavin R. Meehan, Catharien M. U. Hilkens, James M. Brewer, Ranjeny Thomas, Paul Garside, Huw D. Lewis, David C. Wraith, David F. Tough
Publikováno v:
Annals of the Rheumatic Diseases
Increasingly earlier identification of individuals at high risk of rheumatoid arthritis (RA) (eg, with autoantibodies and mild symptoms) improves the feasibility of preventing or curing disease. The use of antigen-specific immunotherapies to reinstat
Currently, treatments for rheumatoid arthritis (RA) are focussed on treatment of disease symptoms rather than addressing the cause of disease, which could lead to remission and cure. Central to disease development is the induction of autoimmunity thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b77bfde9ac164f0fa3bcad80e15aeb5
https://doi.org/10.1101/2022.01.07.475399
https://doi.org/10.1101/2022.01.07.475399