Zobrazeno 1 - 10
of 219
pro vyhledávání: '"James M Brewer"'
Autor:
Teerawit Audshasai, Jonathan A. Coles, Stavros Panagiotou, Shadia Khandaker, Hannah E. Scales, Morten Kjos, Murielle Baltazar, Julie Vignau, James M. Brewer, Aras Kadioglu, Marie Yang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The entry routes and translocation mechanisms of microorganisms or particulate materials into the central nervous system remain obscure We report here that Streptococcus pneumoniae (pneumococcus), or polystyrene microspheres of similar size,
Externí odkaz:
https://doaj.org/article/a69df22b4cba440db00265f14bfb2761
Autor:
Catriona T. Prendergast, Robert A. Benson, Hannah E. Scales, Caio Santos Bonilha, John J. Cole, Iain McInnes, James M. Brewer, Paul Garside
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Mechanisms governing entry and exit of immune cells into and out of inflamed joints remain poorly understood. We sought herein to identify the key molecular pathways regulating such migration. Using murine models of inflammation in conjunction with m
Externí odkaz:
https://doaj.org/article/5d1175430835444c926fbbd904727585
Autor:
Omar A. Alfituri, Juan F. Quintana, Annette MacLeod, Paul Garside, Robert A. Benson, James M. Brewer, Neil A. Mabbott, Liam J. Morrison, Paul Capewell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/9d03bc7f88f44e9eb670e04cf4dded3a
Autor:
Shaima Al Khabouri, Robert A. Benson, Catriona T. Prendergast, Joshua I. Gray, Thomas D. Otto, James M. Brewer, Paul Garside
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was asse
Externí odkaz:
https://doaj.org/article/f24f091353d845b49a310b48bae536ce
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The junctional adhesion molecule-A (JAM-A) is a cell surface adhesion molecule expressed on platelets, epithelial cells, endothelial cells and leukocytes (e. g. monocytes and dendritic cells). JAM-A plays a relevant role in leukocyte trafficking and
Externí odkaz:
https://doaj.org/article/bc2d700e834344a08d660c40e5ec753d
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against di
Externí odkaz:
https://doaj.org/article/fa689ace3696499499ac9830b9c00484
Autor:
Omar A. Alfituri, Juan F. Quintana, Annette MacLeod, Paul Garside, Robert A. Benson, James M. Brewer, Neil A. Mabbott, Liam J. Morrison, Paul Capewell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
African trypanosomes are single-celled extracellular protozoan parasites transmitted by tsetse fly vectors across sub-Saharan Africa, causing serious disease in both humans and animals. Mammalian infections begin when the tsetse fly penetrates the sk
Externí odkaz:
https://doaj.org/article/0534fa510d984e8e8d6b6f571924ce7f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Malaria transmission is effected by intra-erythrocytic parasites that commit to sexual development and form gametocytes. Here, the authors show that early reticulocytes in the major sites of haematopoiesis establish a cryptic asexual cycle; this cycl
Externí odkaz:
https://doaj.org/article/3a394ccac7a34884be1fb342aacb5e2b
Autor:
Mariola Kurowska-Stolarska, Stefano Alivernini, Emma Garcia Melchor, Aziza Elmesmari, Barbara Tolusso, Clare Tange, Luca Petricca, Derek S. Gilchrist, Gabriele Di Sante, Chantal Keijzer, Lynn Stewart, Clara Di Mario, Vicky Morrison, James M. Brewer, Duncan Porter, Simon Milling, Ronald D. Baxter, David McCarey, Elisa Gremese, Greg Lemke, Gianfranco Ferraccioli, Charles McSharry, Iain B. McInnes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are res
Externí odkaz:
https://doaj.org/article/82ffc64d997240fa87e18b12e513a829
Autor:
Alan J. Hayes, Sanket Rane, Hannah E. Scales, Gavin R. Meehan, Robert A. Benson, Asher Maroof, Juliane Schroeder, Michio Tomura, Neil Gozzard, Andrew J. Yates, Paul Garside, James M. Brewer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Initiation of adaptive immunity involves distinct migratory cell populations coming together in a highly dynamic and spatially organized process. However, we lack a detailed spatiotemporal map of these events due to our inability to track the fate of
Externí odkaz:
https://doaj.org/article/990e096a122f42f8ab6e7b00751d7cba