Výsledky vyhledávání - "James M B Gordon"

Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex

Autor: James M. B. Gordon, Murray Stewart, Shintaro Aibara

Publikováno v: Nucleic Acids Research

Transcription-export complex 2 (TREX-2, or THSC) facilitates localization of actively transcribing genes such as GAL1 to the nuclear periphery, contributes to the generation of export-competent mRNPs and influences gene expression through interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b940912365fc9ea4a89d7c22edf78c0
https://doi.org/10.1093/nar/gkx158

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Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae

Autor: James M. B. Gordon, Murray Stewart, Anja S. Riesterer, Shintaro Aibara, Stephen H. McLaughlin

Publikováno v: Nucleic Acids Research

In Saccharomyces cerevisiae generation of export-competent mRNPs terminates the nuclear phase of the gene expression pathway and facilitates transport to the cytoplasm for translation. Nab2 functions in this process to control both mRNP compaction th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abbd864773745f146e6632dd27801b7
http://europepmc.org/articles/PMC5388407

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RNA recognition and self-association of CPEB4 is mediated by its tandem RRM domains

Autor: James M. B. Gordon, Maria J. Macias, Enrique Pedroso, Constanze Schelhorn, Lidia Ruiz, Javier Alguacil

Publikováno v: Nucleic Acids Research

Cytoplasmic polyadenylation is regulated by the interaction of the cytoplasmic polyadenylation element binding proteins (CPEB) with cytoplasmic polyadenylation element (CPE) containing mRNAs. The CPEB family comprises four paralogs, CPEB1–4, each c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a820399f0456e69562c288b8caa4e3b
https://doi.org/10.1093/nar/gku700

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Reconstitution of CF IA from Overexpressed Subunits Reveals Stoichiometry and Provides Insights into Molecular Topology

Autor: Andrew Bohm, Claire Moore, Melissa L. Liriano, Jason N. Kuehner, Walter F. Stafford, Celia J. Harrison, Mathias Bach Poulsen, James M. B. Gordon, Sergei Shikov, Eunhee Lee

Publikováno v: Biochemistry. 50:10203-10214

Yeast cleavage factor I (CF I) is an essential complex of five proteins that binds signal sequences at the 3' end of yeast mRNA. CF I is required for correct positioning of a larger protein complex, CPF, which contains the catalytic subunits executin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce43e030533671bed63736286c5f84
https://doi.org/10.1021/bi200964p

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Interactions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture

Autor: Panagiotis Karahalios, Tanya V. Aspinall, James M B Gordon, John Paul Bukowski, Johanna M. Avis, Hayley J. Bennett, Scott C. Walker, David R. Engelke

Publikováno v: Nucleic Acids Research

Ribonuclease MRP is an endonuclease, related to RNase P, which functions in eukaryotic pre-rRNA processing. In Saccharomyces cerevisiae, RNase MRP comprises an RNA subunit and ten proteins. To improve our understanding of subunit roles and enzyme arc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f4288ccb6b8c3ad4c3838f17563650
http://europepmc.org/articles/PMC2095792

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Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation

Autor: Maria J. Macias, Javier Fernandez-Chamorro, Rosario Francisco-Velilla, Encarnación Martínez-Salas, Jorge Ramajo, David Piñeiro, James M. B. Gordon

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nucleic Acids Research

Ribonucleic acid (RNA)-binding proteins are key players of gene expression control. We have shown that Gemin5 interacts with internal ribosome entry site (IRES) elements and modulates initiation of translation. However, little is known about the RNA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a913fb65c3c3be4e1af1c672b3f0782
http://hdl.handle.net/10261/124770

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The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site

Autor: Badri Nath Singh, Susan D. Lee, James M. B. Gordon, Claire Moore, Michael Hampsey, Mohamed A. Ghazy, Andrew Bohm

Publikováno v: Nucleic Acids Research

Polyadenylation of eukaryotic mRNAs contributes to stability, transport and translation, and is catalyzed by a large complex of conserved proteins. The Pcf11 subunit of the yeast CF IA factor functions as a scaffold for the processing machinery durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb0f318e27101fe6fdb27ddfdef31fa
https://pubmed.ncbi.nlm.nih.gov/21993299

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