Zobrazeno 1 - 10
of 223
pro vyhledávání: '"James M, Wells"'
Autor:
Patrizia Tornabene, James M. Wells
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151464- (2024)
Human pluripotent stem cells (hPSCs) represent an unlimited source of β-like cells for both disease modeling and cellular therapy for diabetes. Numerous protocols have been published describing the differentiation of hPSCs into β-like cells that se
Externí odkaz:
https://doaj.org/article/96ad679984914c558db83ec181e4d8e0
Autor:
Heather A. McCauley, Anne Marie Riedman, Jacob R. Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A. Lang, James M. Wells
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1293-1310 (2023)
Background & Aims: The intestinal stem cell niche is exquisitely sensitive to changes in diet, with high-fat diet, caloric restriction, and fasting resulting in altered crypt metabolism and intestinal stem cell function. Unlike cells on the villus, c
Externí odkaz:
https://doaj.org/article/1572cbb0e6804874852f6a419b62b436
Autor:
Heather A. McCauley, Andrea L. Matthis, Jacob R. Enriquez, Jonah T. Nichol, J. Guillermo Sanchez, William J. Stone, Nambirajan Sundaram, Michael A. Helmrath, Marshall H. Montrose, Eitaro Aihara, James M. Wells
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Enteroendocrine cells (EECs) are specialized gastrointestinal cells that have a role in nutrient sensing and hormone secretion. Here the authors show that peptide YY from EECs regulates nutrient absorption in intestinal organoids.
Externí odkaz:
https://doaj.org/article/50edefa8b4244558bced763cdc66baa9
Autor:
Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a sign
Externí odkaz:
https://doaj.org/article/0ee51be150a74c26a536081300641197
Autor:
Suman Pradhan, Sayali S. Karve, Alison A. Weiss, Jennifer Hawkins, Holly M. Poling, Michael A. Helmrath, James M. Wells, Heather A. McCauley
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 171-190 (2020)
Background & Aims: Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome. The murine inte
Externí odkaz:
https://doaj.org/article/6bbfdf62ec0b4631968dc0990ad90901
Autor:
Stefanie Krick, E. Scott Helton, Molly Easter, Seth Bollenbecker, Rebecca Denson, Rennan Zaharias, Phillip Cochran, Shia Vang, Elex Harris, James M. Wells, Jarrod W. Barnes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chronic obstructive pulmonary disease (COPD) is a systemic disease strongly associated with cigarette smoking, airway inflammation, and acute disease exacerbations. Changes in terminal sialylation and fucosylation of asparagine (N)-linked glycans hav
Externí odkaz:
https://doaj.org/article/a77f108632ae4f6893af909e448c6f15
Autor:
Stephen L. Trisno, Nara S. Higano, Dan Kechele, Talia Nasr, Wendy Chung, Aaron M. Zorn, Jason C. Woods, James M. Wells, Paul S. Kingma
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
In this case report, we describe the clinical course of a neonate who presented initially with respiratory distress and later with choking during feeding. He was subsequently found to have an esophageal bronchus to the right upper lung lobe, a rare c
Externí odkaz:
https://doaj.org/article/a9a3413d84a3468e892cb4e12504049b
Autor:
Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Externí odkaz:
https://doaj.org/article/22d587f58b184e8ba68ff0e088f3e21b
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 353-363 (2018)
Gastric diseases, including peptic ulcer disease and gastric cancer, are highly prevalent in human beings. Despite this, the cellular biology of the stomach remains poorly understood relative to other gastrointestinal organs such as the liver, intest
Externí odkaz:
https://doaj.org/article/0d9a5acfd88b4c2485d0a80be18b953d
Nonsense mutation in the novel PERCC1 gene as a genetic cause of congenital diarrhea and enteropathy
Autor:
Dina, Marek-Yagel, Emily, Stenke, Ben, Pode-Shakked, Cara, Dunne, Ellen, Crushell, Anthea, Bryce-Smith, Michael, McDermott, Maureen J, O'Sullivan, Alvit, Veber, Mansa, Krishnamurthy, James M, Wells, Yair, Anikster, Billy, Bourke
Publikováno v:
Human Genetics. 142:691-696
Congenital diarrheas and enteropathies (CODEs) constitute a heterogeneous group of individually rare disorders manifesting with infantile-onset chronic diarrhea. Genomic deletions in chromosome 16, encompassing a sequence termed the ‘intestine-crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1bfc06a30c6835917b1a23dd4244ac
https://doi.org/10.1007/s00439-022-02486-1
https://doi.org/10.1007/s00439-022-02486-1