Zobrazeno 1 - 10
of 31
pro vyhledávání: '"James M, Seckler"'
Autor:
James M. Seckler, Paulina M. Getsy, Walter J. May, Benjamin Gaston, Santhosh M. Baby, Tristan H. J. Lewis, James N. Bates, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid body glomus cells (PGCs) of rats that then activates chemosensory afferents of the carotid
Externí odkaz:
https://doaj.org/article/a0ec66bd442e4023aed4041f3f036733
Autor:
Benjamin Gaston, Santhosh M. Baby, Walter J. May, Alex P. Young, Alan Grossfield, James N. Bates, James M. Seckler, Christopher G. Wilson, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME
Externí odkaz:
https://doaj.org/article/41ace98fd93a40d48fca5e4e1a53a813
Autor:
Michael W. Jenkins, Faiza Khalid, Santhosh M. Baby, Walter J. May, Alex P. Young, James N. Bates, Feixiong Cheng, James M. Seckler, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl
Externí odkaz:
https://doaj.org/article/e8f4803ec10a4a88badb5c1309e08a21
Autor:
Paulina M. Getsy, Santhosh M. Baby, Ryan B. Gruber, Benjamin Gaston, Tristan H. J. Lewis, Alan Grossfield, James M. Seckler, Yee-Hsee Hsieh, James N. Bates, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Endogenous and exogenously administered S-nitrosothiols modulate the activities of central and peripheral systems that control breathing. We have unpublished data showing that the deleterious effects of morphine on arterial blood-gas chemistry (i.e.,
Externí odkaz:
https://doaj.org/article/917a88664b534ff3bbaeda91c4bb6f4b
Autor:
James M Seckler, Nikki M Meyer, Spencer T Burton, James N Bates, Benjamin Gaston, Stephen J Lewis
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187149 (2017)
Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these mole
Externí odkaz:
https://doaj.org/article/c4ec4f213c964ba39adb53a95d6dab6c
Autor:
Paulina M. Getsy, Alex P. Young, James N. Bates, Santhosh M. Baby, James M. Seckler, Alan Grossfield, Yee-Hsee Hsieh, Tristan H.J. Lewis, Michael W. Jenkins, Benjamin Gaston, Stephen J. Lewis
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 153
S-nitrosothiols exert multiple effects on neural processes in the central and peripheral nervous system. This study shows that intravenous infusion of S-nitroso-L-cysteine (SNO-L-CYS, 1 μmol/kg/min) in anesthetized male Sprague Dawley rats elicits (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a2cc4fbf92c472d96bfc02b005cfc1
https://pubmed.ncbi.nlm.nih.gov/36076552
https://pubmed.ncbi.nlm.nih.gov/36076552
Publikováno v:
Proteins
1.AbstractArrestins are important scaffolding proteins that are expressed in all vertebrate animals. They regulate cell signaling events upon binding to active G-protein coupled receptors (GPCR) and trigger endocytosis of active GPCRs. While many of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4193c8797e07cfa8eeb231a3ae0903b3
https://doi.org/10.22541/au.165331624.44817659/v1
https://doi.org/10.22541/au.165331624.44817659/v1
Autor:
James M. Seckler
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 44(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9147c8741d31faab65ed90def69fb681
https://pubmed.ncbi.nlm.nih.gov/35484375
https://pubmed.ncbi.nlm.nih.gov/35484375
Autor:
Paulina M. Getsy, Alex P. Young, Alan Grossfield, James M. Seckler, Christopher G. Wilson, Benjamin Gaston, James N. Bates, Stephen J. Lewis
Publikováno v:
Respiratory physiologyneurobiology. 302
We determined whether intravenous injections of the membrane-permeable ventilatory stimulants, D-cysteine ethyl ester (ethyl (2 S)- 2-amino-3-sulfanylpropanoate) (D-CYSee) and D-cystine dimethyl ester (methyl (2 S)- 2-amino-3-[[(2 S)- 2-amino-3-metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e06f0ddf63311cb182f993e9628e813
https://pubmed.ncbi.nlm.nih.gov/35447347
https://pubmed.ncbi.nlm.nih.gov/35447347
Autor:
Tristan H J, Lewis, Walter J, May, Alex P, Young, James N, Bates, Santhosh M, Baby, Paulina M, Getsy, Rita M, Ryan, Yee-Hsee, Hsieh, James M, Seckler, Stephen J, Lewis
Publikováno v:
Biomedicine & Pharmacotherapy. 156:113939
This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volume, minute v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3373b0004af1f7a6bd6cc8bd3a180ae0
https://doi.org/10.1016/j.biopha.2022.113939
https://doi.org/10.1016/j.biopha.2022.113939