Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James M, Schmidt"'
Autor:
Elizabeth M, Martinez, Robert J, Sepanski, A Dawn, Jennings, James M, Schmidt, Thomas J, Cholis, Meaghan E, Dominy, Sanaz B, Devlin, Lindsay Floyd, Eilers, Arno L, Zaritsky, Sandip A, Godambe
Publikováno v:
Journal for Healthcare Quality. 45:59-68
Pediatric sepsis is a leading cause of death among children. Electronic alert systems may improve early recognition but do not consistently result in timely interventions given the multitude of clinical presentations, lack of treatment consensus, sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8486480a12f36cc1b50dbd4a68cca7
https://doi.org/10.1097/jhq.0000000000000363
https://doi.org/10.1097/jhq.0000000000000363
Publikováno v:
Southern Medical Journal. 112:277-282
OBJECTIVES Frequently, infants and children require sedation to facilitate noninvasive procedures and imaging studies. Propofol and dexmedetomidine are used to achieve deep procedural sedation in children. The objective of this study was to compare t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64065f2c967d2671f978c007f998965e
https://doi.org/10.14423/smj.0000000000000973
https://doi.org/10.14423/smj.0000000000000973
Publikováno v:
The American Journal of Emergency Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba0c015fdb8ff9a709308e0665323a9
https://pubmed.ncbi.nlm.nih.gov/33637363
https://pubmed.ncbi.nlm.nih.gov/33637363
Autor:
Elizabeth M. Martinez, Robert J. Sepanski, Yvette M. Conyers, A. Dawn Jennings, James M. Schmidt, Regina L. Dawson, Sandip A. Godambe
Publikováno v:
Pediatrics. 146:531-532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16081046798eac1cf0433378cab1958
https://doi.org/10.1542/peds.146.1ma6.531b
https://doi.org/10.1542/peds.146.1ma6.531b
Autor:
Robert J. Sepanski, A. Dawn Jennings, James M. Schmidt, Elizabeth Martinez, Sandip A. Godambe
Publikováno v:
Abstracts.
Background Missing signs of sepsis can result in delayed diagnosis, treatment and complications. We have introduced an ED-based Children At High Risk(CAHR-AT) tool to improve recognition, team critical thinking, and patient outcomes. Delayed recognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25effa254f6fab49ab2d94edd4b20589
https://doi.org/10.1136/bmjoq-2019-ihi.1
https://doi.org/10.1136/bmjoq-2019-ihi.1
Publikováno v:
The American Journal of Emergency Medicine. 43:287.e1-287.e3
We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection. All three cases (ages 11 months, 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d17aff4ebd04bcc3f09f870926502b
https://doi.org/10.1016/j.ajem.2020.09.034
https://doi.org/10.1016/j.ajem.2020.09.034
Autor:
Alan Wilson, Jason P. Healy, Robert Brommage, Xiaolian Xu, Qiang Han, Praveen K. Pabba, Kenneth G. Carson, Gardyan Michael Walter, James M. Schmidt, Andrea Y. Thompson, Ross Mabon, Kristen M. Terranova, Joseph Barbosa, James E. Tarver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1184-1187
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990401977cc295fc807cd6291e6f9d8d
https://doi.org/10.1016/j.bmcl.2016.01.038
https://doi.org/10.1016/j.bmcl.2016.01.038
Autor:
Wei He, Kenneth G. Carson, Victoria K. Lombardo, Praveen K. Pabba, James E. Tarver, Qiang Han, Alan Wilson, James M. Schmidt, Robert Brommage, Gardyan Michael Walter, Andrea Y. Thompson, Joseph Barbosa
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f993b0f26061479736dc8a0b504f7173
https://pubmed.ncbi.nlm.nih.gov/26897593
https://pubmed.ncbi.nlm.nih.gov/26897593
Autor:
James M. Schmidt
Publikováno v:
New Horizons in Predictive Drug Metabolism and Pharmacokinetics ISBN: 9781849738286
Understanding the metabolism of a compound by identifying which metabolites are formed during in vitro or in vivo studies—that is, “metabolite profiling”—is a critical part of the drug discovery and development process, from assisting in lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d583a03d121b4c6d3e288640ac0aa494
https://doi.org/10.1039/9781782622376-00131
https://doi.org/10.1039/9781782622376-00131
Autor:
Phong Nguyen, Sue J. Swanson, Jyoti R. Patel, Jiahong Wang, Annika Goos-Nilsson, J.T. Link, Peer B. Jacobson, Zhenping Tian, Marlena Grynfarb, Jia Du, James M. Schmidt, Brad Zinker, Thomas W von Geldern, Steven Fung, Thomas J Reisch, Denise Wilcox, Gary Rotert, Benjamin C. Lane, Bach Hickman, Bryan Sorensen
Publikováno v:
Journal of Medicinal Chemistry. 48:5295-5304
Much has been learned about the consequences of glucocorticoid receptor antagonism by studying steroidal active antagonists such as RU-38486 (1). In the liver glucocorticoid receptor antagonism suppresses hepatic glucose production decreasing plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a32d864eae96571ed87d585d19ef98
https://doi.org/10.1021/jm050205o
https://doi.org/10.1021/jm050205o