Výsledky vyhledávání - "James M, Rini"

Akademický článek

Intranasal HD-Ad-FS vaccine induces systemic and airway mucosal immunities against SARS-CoV-2 and systemic immunity against SARS-CoV-2 variants in mice and hamsters

Autor: Peter Zhou, Jacqueline Watt, Juntao Mai, Huibi Cao, Zhijie Li, Ziyan Chen, Rongqi Duan, Ying Quan, Anne-Claude Gingras, James M. Rini, Jim Hu, Jun Liu

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The outbreak of coronavirus disease 19 (COVID-19) has highlighted the demand for vaccines that are safe and effective in inducing systemic and airway mucosal immunity against the aerosol transmission of severe acute respiratory syndrome coronavirus 2

Externí odkaz: https://doaj.org/article/9171d23713004e7b9e7258511c3c7f77

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Akademický článek

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2

Publikováno v: Cell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Background The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However,

Externí odkaz: https://doaj.org/article/db6a511fdc1941d0b06de120ed47f460

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Akademický článek

A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Serological tests are important diagnostic and disease surveillance tools for addressing the COVID-19 pandemic. Here, the authors present a tri-part Nanoluciferase based assay to detect antibodies against SARS-CoV-2.

Externí odkaz: https://doaj.org/article/449b1c0635934549a4cf789704798ab6

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Akademický článek

Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey

Autor: Leslie Y. T. Leung, Srijit Khan, Patrick Budylowski, Zhijie Li, Sofiya Goroshko, Yanling Liu, Shilan Dong, James R. Carlyle, James M. Rini, Mario Ostrowski, Götz R. A. Ehrhardt

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

SARS-CoV-2 is a newly emerged betacoronavirus and the causative agent for the COVID-19 pandemic. Antibodies recognizing the viral spike protein are instrumental in natural and vaccine-induced immune responses to the pathogen and in clinical diagnosti

Externí odkaz: https://doaj.org/article/b2a4e068165a428eb2240253c9e710f6

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Akademický článek

A simple protein-based surrogate neutralization assay for SARS-CoV-2

Publikováno v: JCI Insight, Vol 5, Iss 19 (2020)

Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcom

Externí odkaz: https://doaj.org/article/ad2b246270df4becb301a339c8a9e81c

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Akademický článek

Receptor-binding loops in alphacoronavirus adaptation and evolution

Autor: Alan H. M. Wong, Aidan C. A. Tomlinson, Dongxia Zhou, Malathy Satkunarajah, Kevin Chen, Chetna Sharon, Marc Desforges, Pierre J. Talbot, James M. Rini

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analy

Externí odkaz: https://doaj.org/article/f6588e45349a4419aa4c7ce1d24b3317

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Akademický článek

Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)

Autor: Zhijie Li, Michael Fischer, Malathy Satkunarajah, Dongxia Zhou, Stephen G. Withers, James M. Rini

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

POGLUT1 is a protein-O-glucosyltransferase that transfers glucose and xylose to the EGF-like domains of Notch and other signaling receptors. Here the authors report the structure of human POGLUT1 in complexes with 3 different EGF-like domains and don

Externí odkaz: https://doaj.org/article/7319d160abf34c1da5150afd1e429e25

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Akademický článek

The human coronavirus HCoV-229E S-protein structure and receptor binding

Autor: Zhijie Li, Aidan CA Tomlinson, Alan HM Wong, Dongxia Zhou, Marc Desforges, Pierre J Talbot, Samir Benlekbir, John L Rubinstein, James M Rini

Publikováno v: eLife, Vol 8 (2019)

The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Report

Externí odkaz: https://doaj.org/article/eed3c0e9a1a2460c8ad3b9c833f16c92

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