Zobrazeno 1 - 10
of 378
pro vyhledávání: '"James M, Reuben"'
Autor:
Jangsoon Lee, Kumiko Kida, Jiwon Koh, Huey Liu, Ganiraju C. Manyam, Young Jin Gi, Dileep R. Rampa, Asha S. Multani, Jing Wang, Gitanjali Jayachandran, Dae-Won Lee, James M. Reuben, Aysegul Sahin, Lei Huo, Debu Tripathy, Seock-Ah Im, Naoto T. Ueno
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Anti-HER2 therapies, including the HER2 antibody–drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd), have led to improved survival outcomes in patients with HER2-overexpressing (HER2+) metast
Externí odkaz:
https://doaj.org/article/96dec9fe852b4c2f9909c30d5560016b
Autor:
Lucia Ruojia Wu, Peng Dai, Michael Xiangjiang Wang, Sherry Xi Chen, Evan N. Cohen, Gitanjali Jayachandran, Jinny Xuemeng Zhang, Angela V. Serrano, Nina Guanyi Xie, Naoto T. Ueno, James M. Reuben, Carlos H. Barcenas, David Yu Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Highly multiplexed ddPCR for sensitive nucleic acid quantitation remains challenging due to limited fluorescence channels. Here the authors report quantitative amplicon sequencing (QASeq), a PCR-based molecular barcoding NGS approach which is compati
Externí odkaz:
https://doaj.org/article/4d7f4e4784404a73a971f604e13766e8
Autor:
Megumi Kai, Angela N. Marx, Diane D. Liu, Yu Shen, Hui Gao, James M. Reuben, Gary Whitman, Savitri Krishnamurthy, Merrick I. Ross, Jennifer K. Litton, Bora Lim, Nuhad Ibrahim, Takahiro Kogawa, Naoto T. Ueno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Talimogene laherparepvec (T-VEC) is an immunotherapy that generates local tumor lysis and systemic antitumor immune response. We studied the efficacy of intratumoral administration of T-VEC as monotherapy for inoperable locoregional recurren
Externí odkaz:
https://doaj.org/article/c37b0ab005ba4205ac526ecb4d11aff8
Autor:
Xiaotong Li, Sushant Kumar, Arif Harmanci, Shantao Li, Robert R. Kitchen, Yan Zhang, Vikram B. Wali, Sangeetha M. Reddy, Wendy A. Woodward, James M. Reuben, Joel Rozowsky, Christos Hatzis, Naoto T. Ueno, Savitri Krishnamurthy, Lajos Pusztai, Mark Gerstein
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Inflammatory breast cancer (IBC) has a highly invasive and metastatic phenotype. However, little is known about its genetic drivers. To address this, we report the largest cohort of whole-genome sequencing (WGS) of IBC cases. Meth
Externí odkaz:
https://doaj.org/article/1add699a6a154a93abe43aacbd318851
Autor:
Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang, Steven H. Lin
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-9 (2020)
Abstract Background Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression fr
Externí odkaz:
https://doaj.org/article/fcd183c6995e4048b1545ebe0eee860e
Autor:
Naoto T. Ueno, Rie K. Tahara, Takeo Fujii, James M. Reuben, Hui Gao, Babita Saigal, Anthony Lucci, Toshiaki Iwase, Nuhad K. Ibrahim, Senthil Damodaran, Yu Shen, Diane D. Liu, Gabriel N. Hortobagyi, Debu Tripathy, Bora Lim, Beth A. Chasen
Publikováno v:
Cancer Medicine, Vol 9, Iss 3, Pp 1025-1032 (2020)
Abstract Background Radium‐223 dichloride (Ra‐223) is a targeted alpha therapy that induces localized cytotoxicity in bone metastases. We evaluated the efficacy and safety of Ra‐223 plus hormonal therapy in hormone receptor‐positive (HR+), bo
Externí odkaz:
https://doaj.org/article/cad357d50e8d4880907807ce1272c30c
Autor:
Lori J. Goldstein, Raymond P. Perez, Denise Yardley, Linda K. Han, James M. Reuben, Hui Gao, Susan McCanna, Beth Butler, Pier Adelchi Ruffini, Yi Liu, Roberto R. Rosato, Jenny C. Chang
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Background Cancer stem cells (CSCs) are purported to be responsible for tumor initiation, treatment resistance, disease recurrence, and metastasis. CXCR1, one of the receptors for CXCL8, was identified on breast cancer (BC) CSCs. Reparixin,
Externí odkaz:
https://doaj.org/article/ac829d2cdaf14d13a5d03603e1a74bd8
Autor:
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Phillip Peabody, Heather B. McBride, Franklin D. Alvarez, Pablo Lopez Bravo, Wei Qiao, Suyu Liu, Luyang Yao, Steven H. Lin, James M. Reuben
Publikováno v:
Translational Lung Cancer Research. 12:109-126
Autor:
Evan N Cohen, Gitanjali Jayachandran, Max R Hardy, Ananya M Venkata Subramanian, Xiangtian Meng, James M Reuben
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241123 (2020)
Circulating tumor cells (CTC) isolated from the peripheral blood of cancer patients by a minimally invasive procedure provide surrogate markers of the tumor that can be repeatedly sampled. However, the selection and enumeration of CTCs by traditional
Externí odkaz:
https://doaj.org/article/c311e38fa30d4b6cb4ae08c68e9a4326
Autor:
Fanny Le Du, Takeo Fujii, Kumiko Kida, Darren W Davis, Minjeong Park, Diane D Liu, Weiguo Wu, Mariana Chavez-MacGregor, Carlos H Barcenas, Vicente Valero, Debu Tripathy, James M Reuben, Naoto T Ueno
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229903 (2020)
BackgroundTumor cells with a mesenchymal phenotype and/or cancer stem-like cells (CSCs) are known to contribute to metastasis and drug resistance. Circulating tumor cells (CTCs) undergoing epithelial-mesenchymal transition (EMT) and CTCs reflecting a
Externí odkaz:
https://doaj.org/article/ed1d5dea18d847e38b50809efaf6b772