Zobrazeno 1 - 10
of 156
pro vyhledávání: '"James M, Gallo"'
Autor:
Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiom
Externí odkaz:
https://doaj.org/article/5c705931ae3749d8b0d5c464d5e8d788
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 360-374 (2023)
Abstract Cancer therapy continues to be plagued by modest therapeutic advances. This is particularly evident in glioblastoma multiforme (GBM) wherein treatment failures are attributed to intratumoral heterogeneity (ITH), a dynamic process of cell sta
Externí odkaz:
https://doaj.org/article/bafee6a496cc4938a52699d63cc1b7ad
Autor:
James M. Gallo
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1082-1091 (2021)
Abstract A novel coronavirus, severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) or coronavirus disease 2019 (COVID‐19), has caused a pandemic that continues to cause catastrophic health and economic carnage and has escalated the id
Externí odkaz:
https://doaj.org/article/dfc746c28f7e43c186e0c0acbc5e6046
Autor:
J. G. Coen van Hasselt, Rayees Rahman, Jens Hansen, Alan Stern, Jaehee V. Shim, Yuguang Xiong, Amanda Pickard, Gomathi Jayaraman, Bin Hu, Milind Mahajan, James M. Gallo, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Avner Schlessinger, Evren U. Azeloglu, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug str
Externí odkaz:
https://doaj.org/article/86f9cff8a37243ebb6125f4c841c6732
Autor:
Mehdi Bouhaddou, Li J. Yu, Serena Lunardi, Spyros K. Stamatelos, Fiona Mack, James M. Gallo, Marc R. Birtwistle, Antje‐Christine Walz
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 419-429 (2020)
Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical trials. However, such prediction remains challenging. Here, we built a quantitative pharmacok
Externí odkaz:
https://doaj.org/article/4f66816e62d5476caa64a75265e11815
Autor:
Anshul Saini, James M Gallo
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009307 (2021)
Drug resistance is a significant obstacle to successful and durable anti-cancer therapy. Targeted therapy is often effective during early phases of treatment; however, eventually cancer cells adapt and transition to drug-resistant cells states render
Externí odkaz:
https://doaj.org/article/6c9e006cf9054e7b99c24469fa567e8f
Autor:
James M. Gallo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 9, Pp 539-542 (2018)
Externí odkaz:
https://doaj.org/article/59a2964cbd4546f581b6c0c49a1e3cef
It is established that efflux transporters of the ATP-binding cassette (ABC) superfamily can affect the pharmacokinetics of drugs through mechanisms pertaining to drug absorption, elimination, and distribution. To characterize the role of multiple tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6a632df7678fb0ee3f152e991d4076
https://doi.org/10.1158/1535-7163.c.6536719.v1
https://doi.org/10.1158/1535-7163.c.6536719.v1
Supplementary File - PDF file 584K, Supplementary Figure 1: Total topotecan pharmacokinetic variables in Abc transporters knock out mouse models at two i.v. dose levels. ; Supplementary Figure 2: Urinary and fecal excretions of total topotecan in Abc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a67f20d10ef74a0401d9024b21c957
https://doi.org/10.1158/1535-7163.22501246
https://doi.org/10.1158/1535-7163.22501246
Supplementary Fig. S1 from Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7157b3fe3f5fc4f8efef88eb70674a1a
https://doi.org/10.1158/1535-7163.22485116
https://doi.org/10.1158/1535-7163.22485116