Zobrazeno 1 - 10
of 116
pro vyhledávání: '"James Lyon"'
Autor:
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1667 (2024)
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. Me
Externí odkaz:
https://doaj.org/article/71afa965af904b5c8fc2cf5045e23fbe
Autor:
Linnet Ongeri, David A. Larsen, Rachel Jenkins, Andrea Shaw, Hannah Connolly, James Lyon, Symon Kariuki, Brenda Penninx, Charles R. Newton, Peter Sifuna, Bernhards Ogutu
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Suicide is an important contributor to the burden of mental health disorders, but community-based suicide data are scarce in many low- and middle-income countries (LMIC) including Kenya. Available data on suicide underestimates th
Externí odkaz:
https://doaj.org/article/3a87df7014eb4d0b910b4ae4dca11400
Autor:
Jeremy Chataway, Tim Soane, Suvankar Pal, Malcolm Macleod, Jing Liao, Fraser S Brown, Charis Wong, Ankur Singh, Gavin Langlands, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Robert Swingler, Peter Connick, Suzanne Quigley, Peter Foley, Alexandra Thompson, Stella A Glasmacher, D Leighton, Arpan R Mehta, Aimal Ahmad Khan, John Cafferkey, Kieren Egan, Hanna M Vesterinen, Maarij Anwar, Caitlin Beagan, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina Kaddouri, Jamie Kiernan, Jiaming Liu, James Lyon, Alyssa Meng, Vivienne Nguyen, Na Hyun Park, Yousuf Rashid, Andrea Salzinger, Bethany Shiell, Olaf Tomala, Fergal M Waldron, Bhuvaneish T Selvaraj
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Objectives Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Here, we detail a systematic and s
Externí odkaz:
https://doaj.org/article/8485ba3c3ebb46a882ab95ef3fcbf8c4
Autor:
Leah A. Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y. Lam, James Lyon, Jocelyn E. Manning Fox, Locksley E. McGann, Patrick E. MacDonald, Seung K. Kim, Janet A. W. Elliott
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell transcriptome studies on the pathology and treatment of diabetes. Using an iterative graded freezin
Externí odkaz:
https://doaj.org/article/81bf17f84f3a48baaaa02563801b21a1
Autor:
Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F. Spigelman, James Lyon, XiaoQing Dai, Jocelyn E. Manning Fox, Patrick E. MacDonald
Publikováno v:
Physiological Reports, Vol 8, Iss 8, Pp n/a-n/a (2020)
Abstract Pancreatic islet insulin secretion is amplified by both metabolic and receptor‐mediated signaling pathways. The incretin‐mimetic and DPPIV inhibitor anti‐diabetic drugs increase insulin secretion, but in humans this can be variable bot
Externí odkaz:
https://doaj.org/article/89a1ec04b4254dde88da44dea078310e
Autor:
Neil A Brummitt, Steven P Bachman, Janine Griffiths-Lee, Maiko Lutz, Justin F Moat, Aljos Farjon, John S Donaldson, Craig Hilton-Taylor, Thomas R Meagher, Sara Albuquerque, Elina Aletrari, A Kei Andrews, Guy Atchison, Elisabeth Baloch, Barbara Barlozzini, Alice Brunazzi, Julia Carretero, Marco Celesti, Helen Chadburn, Eduardo Cianfoni, Chris Cockel, Vanessa Coldwell, Benedetta Concetti, Sara Contu, Vicki Crook, Philippa Dyson, Lauren Gardiner, Nadia Ghanim, Hannah Greene, Alice Groom, Ruth Harker, Della Hopkins, Sonia Khela, Poppy Lakeman-Fraser, Heather Lindon, Helen Lockwood, Christine Loftus, Debora Lombrici, Lucia Lopez-Poveda, James Lyon, Patricia Malcolm-Tompkins, Kirsty McGregor, Laura Moreno, Linda Murray, Keara Nazar, Emily Power, Mireya Quiton Tuijtelaars, Ruth Salter, Robert Segrott, Hannah Thacker, Leighton J Thomas, Sarah Tingvoll, Gemma Watkinson, Katerina Wojtaszekova, Eimear M Nic Lughadha
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135152 (2015)
Plants provide fundamental support systems for life on Earth and are the basis for all terrestrial ecosystems; a decline in plant diversity will be detrimental to all other groups of organisms including humans. Decline in plant diversity has been har
Externí odkaz:
https://doaj.org/article/1e4ae67280624da8b7b52ccea6a931e3
Autor:
Jelena Kolic, WenQing Grace Sun, Haoning Cen, Jessica Ewald, Leanne Beet, Renata Moravcova, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Søs Skovsø, Aliya F. Spigelman, Jocelyn E. Manning Fox, James Lyon, Jianguo Xia, Francis C. Lynn, Anna L. Gloyn, Leonard J. Foster, Patrick E. MacDonald, James D. Johnson
Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. We now define prototypical insulin secretion dynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a009fd2f978fa9bdce6f5fb29dbc27b
https://doi.org/10.1101/2023.05.24.23290298
https://doi.org/10.1101/2023.05.24.23290298
This protocol describes the preparation of various media formulations required for the isolation and culture of human islets, as performed by the Alberta Diabetes Institute IsletCore. http://www.bcell.org/adi-isletcore.html
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d4fa7a1c38f4957c187979e1b9740e
https://doi.org/10.17504/protocols.io.5jyl8nnpdl2w/v3
https://doi.org/10.17504/protocols.io.5jyl8nnpdl2w/v3
Publikováno v:
American Society of Clinical Oncology Educational Book.
Significant advancements have been made in the treatment of advanced melanoma with the use of immune checkpoint inhibitors, novel immunotherapies, and BRAF/MEK-targeted therapies with numerous frontline treatment options. However, there remains subop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93839a0927d1022f33e5cafe04bc5404
https://doi.org/10.1200/edbk_397478
https://doi.org/10.1200/edbk_397478