Zobrazeno 1 - 10
of 28
pro vyhledávání: '"James Longden"'
Autor:
Ralitsa R. Madsen, James Longden, Rachel G. Knox, Xavier Robin, Franziska Völlmy, Kenneth G. Macleod, Larissa S. Moniz, Neil O. Carragher, Rune Linding, Bart Vanhaesebroeck, Robert K. Semple
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 3 (2021)
Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human plur
Externí odkaz:
https://doaj.org/article/4ea0653e3583469b906fa71a429c3620
Autor:
Simon Koplev, James Longden, Jesper Ferkinghoff-Borg, Mathias Blicher Bjerregård, Thomas R. Cox, Janine T. Erler, Jesper T. Pedersen, Franziska Voellmy, Morten O.A. Sommer, Rune Linding
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2784-2791 (2017)
Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbatio
Externí odkaz:
https://doaj.org/article/262e116538d240979a729f07ca49550c
Autor:
Mathias Engel, James Longden, Jesper Ferkinghoff-Borg, Xavier Robin, Gaye Saginc, Rune Linding
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005900 (2018)
Cell migration is a central biological process that requires fine coordination of molecular events in time and space. A deregulation of the migratory phenotype is also associated with pathological conditions including cancer where cell motility has a
Externí odkaz:
https://doaj.org/article/d1af620b97ee481285e062dea5739064
Autor:
Poulomi Banerjee, Arpan R. Mehta, Raja S. Nirujogi, James Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R. Alessi, Bhuvaneish T. Selvaraj, Josef Priller, Siddharthan Chandran
Publikováno v:
Science advances 9(16), eabq0651 (2023). doi:10.1126/sciadv.abq0651
Banerjee, P, Mehta, A, Nirujogi, R S, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, McDade, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D R, Thangaraj Selvaraj, B, Priller, J & Chandran, S 2023, ' Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration ', Science Advances . https://doi.org/10.1126/sciadv.abq0651
Banerjee, P, Mehta, A, Nirujogi, R S, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, McDade, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D R, Thangaraj Selvaraj, B, Priller, J & Chandran, S 2023, ' Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration ', Science Advances . https://doi.org/10.1126/sciadv.abq0651
Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell–derived microglia-like cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe9b8361917d07a830b67f50046784
https://pub.dzne.de/record/257688
https://pub.dzne.de/record/257688
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b739db7191007c307486d0afcb788926
https://doi.org/10.1016/b978-0-12-821618-7.00030-4
https://doi.org/10.1016/b978-0-12-821618-7.00030-4
Autor:
Olivia M Rifai, James Longden, Judi O'Shaughnessy, Michael DE Sewell, Judith Pate, Karina McDade, Michael JD Daniels, Sharon Abrahams, Siddharthan Chandran, Barry W McColl, Christopher R Sibley, Jenna M Gregory
Publikováno v:
Rifai, O M, Longden, J, O'Shaughnessy, J, Sewell, M D E, Pate, J, McDade, K, Daniels, M J D, Abrahams, S, Chandran, S, McColl, B W, Sibley, C R & Gregory, J M 2022, ' Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS ', The Journal of Pathology, vol. 258, no. 4, pp. 366-381 . https://doi.org/10.1002/path.6008
Clinical heterogeneity observed across patients with amyotrophic lateral sclerosis (ALS) is a known complicating factor in identifying potential therapeutics, even within cohorts with the same mutation, such as C9orf72 hexanucleotide repeat expansion
Autor:
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
The most common genetic mutation found in familial and sporadic amyotrophic lateral sclerosis (ALS), as well as fronto-temporal dementia (FTD), is a repeat expansion in the C9orf72 gene. C9orf72 is highly expressed in human myeloid cells, and althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def4539ddae7769a83be08fa47261b76
https://doi.org/10.1101/2022.05.12.491675
https://doi.org/10.1101/2022.05.12.491675
Autor:
Olivia M. Rifai, James Longden, Judi O’Shaughnessy, Michael D.E. Sewell, Karina McDade, Michael J.D. Daniels, Sharon Abrahams, Siddharthan Chandran, Barry McColl, Christopher R. Sibley, Jenna M. Gregory
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are regarded as two ends of a pathogenetic spectrum, termed ALS-frontotemporal spectrum disorder (ALS-FTSD). However, it is currently difficult to predict where on the spectrum an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac71fb27c9e3f5b2f54232833b625af
https://doi.org/10.1101/2021.12.10.471808
https://doi.org/10.1101/2021.12.10.471808
Autor:
Nik Hirani, Ashraff Makda, Richard J. R. Elliott, Neil O. Carragher, John A. Marwick, Kevin Dhaliwal, John C. Dawson, James Longden
Publikováno v:
Marwick, J, Elliott, R, Longden, J, Makda, A, Hirani, N, Dhaliwal, K, Dawson, J C & Carragher, N O 2021, ' Application of a high-content screening assay utilising primary human lung fibroblasts to identify antifibrotic drugs for rapid repurposing in COVID-19 patients ', Slas Discovery . https://doi.org/10.1177/24725552211019405
Slas Discovery
Slas Discovery
Lung imaging and autopsy reports among COVID-19 patients show elevated lung scarring (fibrosis). Early data from COVID-19 patients as well as previous studies from severe acute respiratory syndrome, Middle East respiratory syndrome, and other respira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bbb10fab8a1c71d2d1bd3fbcbc06d2
https://hdl.handle.net/20.500.11820/9bf47e89-d77d-43f8-8cd6-107ddddefb2e
https://hdl.handle.net/20.500.11820/9bf47e89-d77d-43f8-8cd6-107ddddefb2e