Zobrazeno 1 - 10
of 12
pro vyhledávání: '"James Lillie"'
Autor:
Paul Mason, Beirong Liang, Lingyun Li, Trisha Fremgen, Erin Murphy, Angela Quinn, Stephen L Madden, Hans-Peter Biemann, Bing Wang, Aharon Cohen, Svetlana Komarnitsky, Kate Jancsics, Brad Hirth, Christopher G F Cooper, Edward Lee, Sean Wilson, Roy Krumbholz, Steven Schmid, Yibin Xiang, Michael Booker, James Lillie, Kara Carter
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33823 (2012)
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion o
Externí odkaz:
https://doaj.org/article/ca2a1923edbd4b9b8ad45765ca768d84
Autor:
Paul J. Orchard, Helen Klodnitsky, Drew Tietz, Elina Makino, John P. Leonard, Troy C. Lund, James Lillie, Weston P. Miller, John Marshall, Clifford Phaneuf, Alexey Belenki, Marissa Donovan, Jennifer B. Nietupski, Mariet L. Varban
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-3 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-3 (2018)
Certain recessively inherited diseases result from an enzyme deficiency within lysosomes. In mucopolysaccharidoses (MPS), a defect in glycosaminoglycan (GAG) degradation leads to GAG accumulation followed by progressive organ and multiple system dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2ef94242a0a81616505d0bf58a56db
http://europepmc.org/articles/PMC5859120
http://europepmc.org/articles/PMC5859120
Autor:
Elina Makino, Paul J. Orchard, John P. Leonard, James Lillie, Troy C. Lund, Weston P. Miller, John Marshall, Marissa Donovan, Clifford Phaneuf, Drew Tietz, Mariet L. Varban, Jennifer B. Nietupski, Alexey Belenki, Helen Klodnitsky
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Certain recessively inherited diseases result from an enzyme deficiency within lysosomes. In mucopolysaccharidoses (MPS), a defect in glycosaminoglycan (GAG) degradation leads to GAG accumulation followed by progressive organ and multiple system dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b46a1dd1585f47103579c809b065d28
https://doi.org/10.1038/s41598-018-22078-2
https://doi.org/10.1038/s41598-018-22078-2
Autor:
Joseph Gans, Rajashree McLaren, Yide Jiang, Kara Carter, Beverly A. Teicher, Stephen L. Madden, Michael Booker, Yinyin Huang, Tatiana Gladysheva, Beirong Liang, Mark A. Goldberg, Paul T. Mason, Mindy Zhang, Hans-Peter Biemann, James Lillie, Lilly Chai, Katherine W. Klinger, Ann Byrne, Michael R. Dufault
Publikováno v:
Experimental Cell Research. 316:258-271
The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein within the 19S complex (19S cap; PA700) is responsible for substrate deubiquitination during proteasomal degradation. The role of PSMD14 in cell proliferation and senescence was explored u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571576d936cfa44aaacbf7a53d027a86
https://doi.org/10.1016/j.yexcr.2009.08.018
https://doi.org/10.1016/j.yexcr.2009.08.018
Autor:
Zhiping Chen, Paul M. Ridker, Masashi Sakuma, Tracy L. Dowie, Yunmei Wang, Alexandre do Canto Zago, Peter Libby, Can Shi, Louis Poisson, Kevin Croce, Aruna D. Pradhan, Aileen Healy, Michael D. Pickard, Joseph M. Garasic, James Lillie, Daniel I. Simon, Andrew I. Damokosh
Publikováno v:
Circulation. 113:2278-2284
Background— Platelets participate in events that immediately precede acute myocardial infarction. Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression prece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbbdf7be88326d7a1a663bb45d4ce7d
https://doi.org/10.1161/circulationaha.105.607333
https://doi.org/10.1161/circulationaha.105.607333
Autor:
Jay P. Morgenstern, Rosana Kapeller, James Lillie, Ann Moriarty, Elizabeth Siebert, Louis A. Tartaglia, Troy Chickering, Hilde Stubdal, Kelly Theriault, Ann Strauss
Publikováno v:
Journal of Biological Chemistry. 274:24980-24986
A mutation in the tub gene leads to maturity-onset obesity, insulin resistance, and progressive retinal and cochlear degeneration in mice. tub is a member of a growing family of genes that encode proteins of unknown function that are remarkably conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2958c9a031eb7126ea29b6bd43bd802a
https://doi.org/10.1074/jbc.274.35.24980
https://doi.org/10.1074/jbc.274.35.24980
Autor:
Stephen L. Madden, Steven Schmid, Yibin Xiang, Aharon Cohen, Lingyun Li, Kara Carter, Erin Murphy, Sean M. Wilson, Paul T. Mason, Trisha Fremgen, James Lillie, Brad Hirth, Michael Booker, Edward Lee, Svetlana Komarnitsky, Roy Krumbholz, Christopher G.F. Cooper, Bing Wang, Hans-Peter Biemann, Beirong Liang, Angela Quinn, Kate Jancsics
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e33823 (2012)
PLoS ONE, Vol 7, Iss 3, p e33823 (2012)
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55663e17529ee8d5e15d3607305dd715
http://europepmc.org/articles/PMC3310881
http://europepmc.org/articles/PMC3310881
Autor:
Joshua Pacheco, Wei-Lien Chuang, James Lillie, Stephen L. Madden, Diane Copeland, Kara Carter, Beverly A. Teicher, Seng H. Cheng, Yide A. Jiang, Mark A. Goldberg, Ann Byrne, Yibin Xiang, Rajashree McLaren, Lilly Chai, Mindy Zhang, Michael R. Dufault, John P. Leonard, Michael J. Vasconcelles, Yinyin Huang, Xiaokui Zhang, Katherine W. Klinger, Shruti Madhiwalla
Publikováno v:
International journal of oncology. 38(3)
Glucosylceramide synthase (GCS) is a key enzyme engaged in the biosynthesis of glycosphingolipids and in regulating ceramide metabolism. Studies exploring alterations in GCS activity suggest that the glycolase may have a role in chemosensitizing tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8db1b71a1f62003c5cc04fe6e11e9d9
https://pubmed.ncbi.nlm.nih.gov/21186402
https://pubmed.ncbi.nlm.nih.gov/21186402
Autor:
Yunmei Wang, Louis Poisson, Kevin Croce, Joseph M. Garasic, Daniel I. Simon, Paul M. Ridker, Michael D. Pickard, Masashi Sakuma, Aruna D. Pradhan, Alexandre C. Zago, Tracy L. Dowie, Aileen Healy, Can Shi, James Lillie, Andrew I. Damokosh, Peter Libby, Zhiping Chen
Publikováno v:
Circulation. 115
We would like to thank Dr Krishnan and colleagues for their interest in our work. They have raised additional limitations of our work and question whether platelets express myeloid-related protein-14 (MRP-14). Their caution is reasonable. However, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334ae15f801efbe4eee47450316a28ff
https://doi.org/10.1161/circulationaha.106.672915
https://doi.org/10.1161/circulationaha.106.672915
Autor:
David I. Smith, Robert C. Bast, D. M. Gershenson, Jeffrey S. Ross, Viji Shridhar, Kimberly R. Kalli, Andrew I. Damokosh, Natalia Iartchouk, William A. Cliby, Gerald P Linette, Karen H. Lu, James Lillie, Sebastian Hoersch, Edwin A. Clark, Lynn C. Hartmann, Scott H. Kaufmann, James Stec
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 11(6)
Purpose: Women with advanced epithelial ovarian cancer are routinely treated with platinum-paclitaxel chemotherapy following cytoreductive surgery, yet only ∼20% achieve long-term disease-free survival. We hypothesized that differences in gene expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e818c46cb600aa91959e06ea23e0f1b
https://pubmed.ncbi.nlm.nih.gov/16278422
https://pubmed.ncbi.nlm.nih.gov/16278422