Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James Lakis"'
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e26b8f7a7796258392d71a65a8ad93
https://doi.org/10.1021/jm000547o
https://doi.org/10.1021/jm000547o
Autor:
Johnson Michael David, Plewe Michael Bruno, Dan Kiel, Kimberly Ann Teston, Ulla G. Sidelmann, Douglas E. Murphy, Min Teng, Atsuo Kuki, Shenghua Shi, Christian K. Sams, James Lakis, Kenna Anderes, Larry Kenneth Truesdale, Jun Feng, Birgitte Andersen, Lars Ynddal, Peter Madsen, John M. May, Jesper Lau, Lotte Bjerre Knudsen, Anthony Lai Ling, Vlad E. Gregor, Christian L. Brand
Publikováno v:
Journal of medicinal chemistry. 45(26)
Highly potent human glucagon receptor (hGluR) antagonists have been prepared employing both medicinal chemistry and targeted libraries based on modification of the core (proximal) dimethoxyphenyl group, the benzyl ether linkage, as well as the (dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f8de2ec1aa4425ee9bc81ce1098b95
https://pubmed.ncbi.nlm.nih.gov/12477359
https://pubmed.ncbi.nlm.nih.gov/12477359
Autor:
Christian K. Sams, Lotte Bjerre Knudsen, Teston Kimberly Ann, Eugenia A. Iatsimirskaia, Anthony Lai Ling, Atsuo Kuki, Peter Madsen, Dan Kiel, Doug Murphy, Vlad E. Gregor, Jesper Lau, Javier Gonzalez, Christian L. Brand, Plewe Michael Bruno, John M. May, James Lakis, Shenghua Shi, Larry Kenneth Truesdale, Ulla G. Sidelmann, Alex Polinsky, Kenna Anderes
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
A series of alkylidene hydrazide derivatives containing an alkoxyaryl moiety was optimized. The resulting hydrazide-ethers were competitive antagonists at the human glucagon receptor. Pharmacokinetic experiments showed fast clearance of most of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1394aba7e4083e65bb5700d91b4cd2dc
https://pubmed.ncbi.nlm.nih.gov/11844695
https://pubmed.ncbi.nlm.nih.gov/11844695
Autor:
Peter Madsen, Tim Kercher, Jarek Kostrowicki, Michael D. L. Johnson, Larry Kenneth Truesdale, Shelley A. Aytes, John M. May, Johannes Cornelis De Jong, Preben H. Olesen, Lotte Bjerre Knudsen, Min Teng, Ingrid Pettersson, János Tibor Kodra, Christine Thomas, Dilip Bhumralkar, Jesper Lau, Ulla Sidelman, Carsten Behrens, Dan Kiel, James Lakis, Anker Steen Jorgensen, Jens J. Holst
Publikováno v:
CIÊNCIAVITAE
University of Copenhagen
University of Copenhagen
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc1ddaf454c10f0439b6442091310c5
https://curis.ku.dk/portal/en/publications/small-molecule-agoallosteric-modulators-of-the-human-glucagonlike-peptide1-hglp1-receptor(59701030-20ec-11dd-bc23-000ea68e967b).html
https://curis.ku.dk/portal/en/publications/small-molecule-agoallosteric-modulators-of-the-human-glucagonlike-peptide1-hglp1-receptor(59701030-20ec-11dd-bc23-000ea68e967b).html
