Zobrazeno 1 - 10 of 46 pro vyhledávání: '"James L. Weeks"'
1
The Protein Kinase A Pathway-Regulated Transcriptome of Endometrial Stromal Fibroblasts Reveals Compromised Differentiation and Persistent Proliferative Potential in Endometriosis
Autor: Lusine Aghajanova, Linda C. Giudice, James L. Weeks, Francisco J. Esteban, José A. Horcajadas, Marco Conti, Camran N. Nezhat
Publikováno v: Endocrinology. 151:1341-1355
Intrinsic abnormalities in transplanted eutopic endometrium are believed to contribute to the pathogenesis of pelvic endometriosis. Herein we investigated transcriptomic differences in human endometrial stromal fibroblasts (hESFs) from women with (hE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d148a2f9aa383416f14fe3bd1188bd0
https://doi.org/10.1210/en.2009-0923
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2
Cyclic GMP Signaling Is Involved in the Luteinizing Hormone-Dependent Meiotic Maturation of Mouse Oocytes1
Autor: Frank S. Menniti, James L. Weeks, Minnie Hsieh, Marco Conti, Sergio Vaccari
Publikováno v: Biology of Reproduction. 81:595-604
It is well established that cAMP signaling is an important regulator of the oocyte meiotic cell cycle. Conversely, the function of cGMP during oocyte maturation is less clear. Herein, we evaluated the expression of cGMP-hydrolyzing phosphodiesterases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3837cc21745333314f30dc8b23b45676
https://doi.org/10.1095/biolreprod.109.077768
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3
N-Terminal Domain of Phosphodiesterase-11A4 (PDE11A4) Decreases Affinity of the Catalytic Site for Substrates and Tadalafil, and is Involved in Oligomerization
Autor: Jackie D. Corbin, James L. Weeks, Roya Zoraghi, Sharron H. Francis
Publikováno v: Biochemistry. 46:10353-10364
The phosphodiesterase-11A (PDE11) family consists of four splice variants (PDE11A1-PDE11A4) that contain a conserved carboxyl-terminal (C-terminal) catalytic domain that hydrolyzes cAMP and cGMP; the amino-termini (N-termini) vary in length and amino
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307d751932f441f97039e4d701e6fd33
https://doi.org/10.1021/bi7009629
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4
High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients
Autor: Jackie D. Corbin, Roya Zoraghi, James L. Weeks, Sharron H. Francis, Alfreda Beasley, Konjeti R. Sekhar
Publikováno v: International Journal of Impotence Research. 17:5-9
The physiological role of phosphodiesterase (PDE)11 is unknown and its biochemical characteristics are poorly understood. We have expressed human His-tagged PDE11A4 and purified the enzyme to apparent homogeneity. PDE11A4 displays K(m) values of 0.97
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c913c369a08abdc46c2d96cc494a64
https://doi.org/10.1038/sj.ijir.3901283
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5
The Fox Guarding the Chicken Coop: Monitoring Exposure to Respirable Coal Mine Dust, 1969–2000
Autor: James L. Weeks
Publikováno v: American Journal of Public Health. 93:1236-1244
Following passage of the Coal Mine Health and Safety Act of 1969, underground coal mine operators were required to take air samples in order to monitor compliance with the exposure limit for respirable dust, a task essential for the prevention of pne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddd90068523c066ae1f3025ced096ee
https://doi.org/10.2105/ajph.93.8.1236
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6
[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
Autor: James L. Weeks, Karl P. Kuhn, Layla F. Saidi, Jackie D. Corbin, Mitsi A. Blount, Yew Seng Jonathan Ho, Alfreda Beasley, James H. Hurley, Sharron H. Francis, Jun Kotera
Publikováno v: Molecular Pharmacology. 63:1364-1372
Sildenafil (Viagra) potentiates penile erection by acting as a nonhydrolyzable analog of cGMP and competing with this nucleotide for catalysis by phosphodiesterase-5 (PDE5), but the characteristics of direct binding of radiolabeled sildenafil to PDE5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9373ca23a8cb017ee313e22095103a8
https://doi.org/10.1124/mol.63.6.1364
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8
Cancer Mortality Patterns Among Hairdressers and Barbers in 24 US States, 1984 to 1995
Autor: James L. Weeks, Mustafa Dosemeci, Anjali Bansal Lamba, Mary H. Ward
Publikováno v: Journal of Occupational and Environmental Medicine. 43:250-258
We evaluated cancer mortality patterns among hairdressers and barbers, according to occupation, coded on 7.2 million death certificates in 24 states from 1984 to 1995. Of the 38, 721 deaths among white and black hairdressers and barbers of both sexes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14593dee54f9f3af9caf83a0f552fee
https://doi.org/10.1097/00043764-200103000-00013
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10
Fatalities construction industry in the United States, 1992 and 1993
Autor: Knut Ringen, Earl S. Pollack, James L. Weeks, Matthew Griffin
Publikováno v: American Journal of Industrial Medicine. 30:325-330
To improve the estimates of occupational fatality rates for persons employed in the construction industry, several sources of data on the number of fatalities (the numerator) and the number of persons engaged in construction work (the denominator) we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2f90ca50ef6c87874b3404e955cf339
https://doi.org/10.1002/(sici)1097-0274(199609)30:3<325::aid-ajim11>3.0.co
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