Zobrazeno 1 - 10
of 72
pro vyhledávání: '"James L. Thorne"'
Autor:
Xiaoying Tian, Giorgia Cioccoloni, Joanna H. Sier, Khalid M. Naseem, James L. Thorne, J. Bernadette Moore
Publikováno v:
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Background Ergothioneine is a naturally occurring metabolite of histidine found in many foods and in high amounts in mushrooms. In vivo, ergothioneine acts as an antioxidant and is widely distributed in most mammalian tissues. While ergothio
Externí odkaz:
https://doaj.org/article/0917465bd8e04706a52ecd527c6cca2b
Autor:
Zixuan Zhang, Kimberley Burrows, Harriett Fuller, Elizabeth K. Speliotes, Kushala W. M. Abeysekera, James L. Thorne, Sarah J. Lewis, Michael A. Zulyniak, J. Bernadette Moore
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1442 (2023)
Evidence for a role for vitamin D in non-alcoholic fatty liver disease (NAFLD) pathogenesis is conflicting. As Mendelian randomisation (MR) avoids many limitations of conventional observational studies, this two-sample bidirectional MR analysis was c
Externí odkaz:
https://doaj.org/article/dfc6f2014fea4812a3321d0d36e605ea
Autor:
Priscilia Lianto, Samantha A. Hutchinson, J. Bernadette Moore, Thomas A. Hughes, James L. Thorne
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103212- (2021)
Summary: Activity of liver x receptor (LXR), the homeostatic regulator of cholesterol metabolism, is elevated in triple-negative breast cancer (BCa) relative to other BCa subtypes, driving drug resistance and metastatic gene signatures. The loci enco
Externí odkaz:
https://doaj.org/article/db14f379e6a841abb675c35092a5078d
Autor:
Diana E. Baxter, Lisa M. Allinson, Waleed S. Al Amri, James A. Poulter, Arindam Pramanik, James L. Thorne, Eldo T. Verghese, Thomas A. Hughes
Publikováno v:
Cancers, Vol 13, Iss 23, p 5979 (2021)
Background: poor prognosis primary breast cancers are typically treated with cytotoxic chemotherapy. However, recurrences remain relatively common even after this aggressive therapy. Comparison of matched tumours pre- and post-chemotherapy can allow
Externí odkaz:
https://doaj.org/article/73089cca0f174b1bb8af28e0d8fe2eac
Autor:
Samantha A. Hutchinson, Priscilia Lianto, J. Bernadette Moore, Thomas A. Hughes, James L. Thorne
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3241 (2019)
Low fruit and vegetable consumption and high saturated fat consumption causes elevated circulating cholesterol and are breast cancer risk factors. During cholesterol metabolism, oxysterols form that bind and activate the liver X receptors (LXRs). Oxy
Externí odkaz:
https://doaj.org/article/bcff7f6c65834a3a8f2cbdf2d7c1a02f
Publikováno v:
British Journal of Nutrition. 129:104-114
Ergothioneine is a naturally occurring amino acid and thiol antioxidant found in high amounts in mushrooms and fermented foods. Humans and animals acquire ergothioneine from the diet through the pH-dependent activity of a membrane transporter, the la
Autor:
Kristina Sæterdal Kømurcu, Ingrid Wilhelmsen, James L Thorne, Stefan Johannes Karl Krauss, Steven Ray Haakon Wilson, Aleksandra Aizenshtadt, Hanne Røberg-Larsen
Oxysterols are potential biomarkers for liver metabolism that are altered under disease conditions such as non-alcoholic fatty liver disease (NAFLD). We here apply sterolomics to organoids used for disease modeling of NAFLD. Using liquid chromatograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::997fd3eacf6d8dbef7a41f89bba86b12
https://doi.org/10.1101/2023.02.22.529551
https://doi.org/10.1101/2023.02.22.529551
Autor:
James L, Thorne, Giorgia, Cioccoloni
Publikováno v:
Advances in experimental medicine and biology. 1390
Fluctuations in concentration of diverse lipid classes occur in response to diet and metabolism. These changes are managed and mediated by a cell network of enzymes, pumps, and carriers under the control of the lipid responsive nuclear receptors. The
Publikováno v:
Nutrition research reviews.
Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous signalling molecules, including microRNAs (miRNAs). Dysregulation of miRNA
Autor:
Giorgia Cioccoloni, Chrysa Soteriou, Alex Websdale, Lewis Wallis, Michael A. Zulyniak, James L. Thorne
Publikováno v:
Critical Reviews in Food Science and Nutrition. 62:1145-1165
Phytosterols and phytostanols are natural products present in vegetable oils, nuts, and seeds, or added to consumer food products whose intake is inversely associated with incidence and prognosis of several cancers. Randomized cancer prevention trial