Výsledky vyhledávání - "James L. Stafford"

Akademický článek

Isolation of Skin Leukocytes Uncovers Phagocyte Inflammatory Responses During Induction and Resolution of Cutaneous Inflammation in Fish

Autor: Amro M. Soliman, Taekwan Yoon, Jiahui Wang, James L. Stafford, Daniel R. Barreda

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Leukocytes offer a critical layer of protection to the host following skin infections. Delineating the kinetics of cutaneous leukocyte recruitment as well as their anti-microbial and regulatory profiles is challenging since it requires the isolation

Externí odkaz: https://doaj.org/article/a273b788e26d4d8f98aeb3c40300d446

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Akademický článek

A Fish Leukocyte Immune-Type Receptor Uses a Novel Intracytoplasmic Tail Networking Mechanism to Cross-Inhibit the Phagocytic Response

Autor: Chenjie Fei, Myron A. Zwozdesky, James L. Stafford

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 14, p 5146 (2020)

Channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs) are a family of immunoregulatory proteins shown to regulate several innate immune cell effector responses, including phagocytosis. The precise mechanisms of IpLITR-mediat

Externí odkaz: https://doaj.org/article/63b094cab8704f798d381ad401f24447

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Akademický článek

Selective Regulation of Cytoskeletal Dynamics and Filopodia Formation by Teleost Leukocyte Immune-Type Receptors Differentially Contributes to Target Capture During the Phagocytic Process

Autor: Dustin M. E. Lillico, Joshua G. Pemberton, James L. Stafford

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Phagocytosis evolved from a fundamental nutrient acquisition mechanism in primitive unicellular amoeboids, into a dynamic and complex component of innate immunity in multicellular organisms. To better understand the cellular mechanisms contributing t

Externí odkaz: https://doaj.org/article/73c46250f67c4b69abe0981616b1db4b

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Akademický článek

Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors

Autor: Chenjie Fei, Joshua G. Pemberton, Dustin M. E. Lillico, Myron A. Zwozdesky, James L. Stafford

Publikováno v: Biology, Vol 5, Iss 1, p 13 (2016)

Across vertebrates, innate immunity consists of a complex assortment of highly specialized cells capable of unleashing potent effector responses designed to destroy or mitigate foreign pathogens. The execution of various innate cellular behaviors suc

Externí odkaz: https://doaj.org/article/1f0e344dcae845ce9d8a1f44b8a646a6

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Abiotic and biotic constituents of oil sands process-affected waters

Autor: Nora A.S. Hussain, James L. Stafford

Publikováno v: Journal of Environmental Sciences. 127:169-186

The oil sands in Northern Alberta are the largest oil sands in the world, providing an important economic resource for the Canadian energy industry. The extraction of petroleum in the oil sands begins with the addition of hot water to the bituminous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967f64df286ec11b9ab61fcd12fb597d
https://doi.org/10.1016/j.jes.2022.06.012

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Identification of distinct LRC- and Fc receptor complex-like chromosomal regions in fish supports that teleost leukocyte immune-type receptors are distant relatives of mammalian Fc receptor-like molecules

Autor: Jiahui Wang, Miodrag Belosevic, James L. Stafford

Publikováno v: Immunogenetics. 73:93-109

Leukocyte immune-type receptors (LITRs) are a large family of immunoregulatory receptor-types originally identified in the channel catfish (Ictalurus punctatus (Ip)LITRs). Phylogenetic analyses of LITRs show that they share distant evolutionary relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872694a11e1b662f40233dcc134ffde8
https://doi.org/10.1007/s00251-020-01193-3

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Polymer-coated TiO2 nanoparticles bioaccumulate, immunoactivate and suppress pathogenic Mycobacterium chelonae clearance when intravenously injected into goldfish (Carassius auratus L.)

Autor: David Boyle, Van A. Ortega, Denina B.D. Simmons, Greg G. Goss, Miodrag Belosevic, Jordan W. Hodgkinson, James L. Stafford

Publikováno v: Environmental Science: Nano. 8:1910-1926

Immunological responses to nanoparticle (NP) exposures have been extensively reported using in vitro cell models. Results show that metal-based NPs and NPs functionalized by a polyacrylic acid (PAA) polymer elicit both the activation of pro-inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eda8bb8f21a46e731d916a37b8fcf541
https://doi.org/10.1039/d1en00039j

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Identification of goldfish (Carassius auratus L.) leukocyte immune-type receptors shows alternative splicing as a potential mechanism for receptor diversification

Autor: James L. Stafford, Jiahui Wang, Miodrag Belosevic

Publikováno v: Molecular Immunology. 125:83-94

Leukocyte immune-type receptors (LITRs) are a multigene family of teleost immunoregulatory proteins that share structural, phylogenetic, and likely functional relationships with several innate immune receptor proteins in other vertebrates, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae491102f9c134c53ae73b2b358c8e3
https://doi.org/10.1016/j.molimm.2020.06.024

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