Zobrazeno 1 - 10
of 87
pro vyhledávání: '"James L. Sherley"'
Autor:
Carl G. Simon, Erich H. Bozenhardt, Christina M. Celluzzi, David Dobnik, Melanie L. Grant, Uma Lakshmipathy, Thiana Nebel, Linda Peltier, Anthony Ratcliffe, James L. Sherley, Glyn N. Stacey, Rouzbeh R. Taghizadeh, Eddie H. P. Tan, Sandrine Vessillier
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to thi
Externí odkaz:
https://doaj.org/article/1a4c1b7ac9dd4b808e25bb9e5b77ce01
Autor:
Hitesh Chopra, Michael P. Daley, Adhya Kumar, James Sugai, Alex Dahlkemper, Darnell Kaigler, James L. Sherley
Publikováno v:
Life, Vol 14, Iss 1, p 51 (2023)
Kinetic stem cell (KSC) counting is a recently introduced first technology for quantifying tissue stem cells in vertebrate organ and tissue cell preparations. Previously, effective quantification of the fraction or dosage of tissue stem cells had bee
Externí odkaz:
https://doaj.org/article/8788e52d54514a99a72225429973b2ba
Autor:
Hitesh Chopra, Chen Cao, Celia Sommer, Alex Dahlkemper, James Sugai, James L. Sherley, Darnell Kaigler
Publikováno v:
Cells, Vol 12, Iss 23, p 2703 (2023)
A continuing limitation and major challenge in the development and utilization of predictable stem cell therapies (SCTs) is the determination of the optimal dosages of stem cells. Herein, we report the quantification of stem cell fractions (SCF) of h
Externí odkaz:
https://doaj.org/article/42d1915fe49b4757a48679ea0024a160
Autor:
James L. Sherley
Publikováno v:
Life, Vol 13, Iss 3, p 614 (2023)
A recently described kinetic stem cell (KSC) counting method was used to investigate the stem-cell-specific effects of commercial growth factor supplements used for expanding stem cells in adipose-tissue-derived mesenchymal cell preparations. The sup
Externí odkaz:
https://doaj.org/article/225e493cce454eb8b8bf38f6c7a830a6
Publikováno v:
Health Services Research & Managerial Epidemiology, Vol 7 (2020)
Black women have been experiencing induced abortions at a rate nearly 4 times that of White women for at least 3 decades, and likely much longer. The impact in years of potential life lost, given abortion’s high incidence and racially skewed distri
Externí odkaz:
https://doaj.org/article/9107fd54b846418197873f294f239080
Publikováno v:
Symmetry, Vol 12, Iss 11, p 1868 (2020)
The loss of genetic fidelity in tissue stem cells is considered a significant cause of human aging and carcinogenesis. Many cellular mechanisms are well accepted for limiting mutations caused by replication errors and DNA damage. However, one mechani
Externí odkaz:
https://doaj.org/article/eabf76f5bc714ab7b3c89502ca2d314d
Autor:
Yang Hoon Huh, Minsoo Noh, Frank R. Burden, Jennifer C. Chen, David A. Winkler, James L. Sherley
Publikováno v:
Stem Cell Research, Vol 14, Iss 2, Pp 144-154 (2015)
There is a long-standing unmet clinical need for biomarkers with high specificity for distributed stem cells (DSCs) in tissues, or for use in diagnostic and therapeutic cell preparations (e.g., bone marrow). Although DSCs are essential for tissue mai
Externí odkaz:
https://doaj.org/article/b882fa6915f14328a052ebdd383da762
Autor:
James L. Sherley
Publikováno v:
The Scientific World Journal, Vol 2, Pp 1906-1921 (2002)
A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts
Externí odkaz:
https://doaj.org/article/59b375fa95884a0d8d1306817fbfa5dc
Autor:
James L. Sherley, Author
This book takes a different kind of critical look at the COVID-19 crisis in the US, exploring the growing concern that the response to COVID-19 in the nation is greatly out of proportion to the actual level of disease threat. The important corollary
